RAD17

RAD17
사용 가능한 구조
PDB	Ortholog 검색: PDBe RCSB
PDB ID 코드 목록
	3A1J, 3G65, 3GGR
식별자
에일리어스	RAD17, CCYC, HR24L, RAD17SP, RAD24, RAD17 체크포인트 클램프 로더 컴포넌트
외부 ID	OMIM: 603139 MGI: 1333807 HomoloGene: 32117 GeneCard: RAD17
유전자 위치(인간)
크르.	5번 염색체(인간)
끝.	69,414,801 bp
유전자 위치(마우스)
크르.	13번 염색체(쥐)
끝.	100,787,559 bp
RNA발현패턴
	상단 표시 위치:
	고환; ; 랑게르한스 섬; ; 자궁내막; ; 흉선; ; 아킬레스건; ; 신경절 융기; ; 림프절; ; 골수 세포; ; 뇌량; ; 췌장체;
	추가 참조 표현식 데이터
	; ; ; ;
	추가 참조 표현식 데이터
유전자 존재론
분자 함수	뉴클레오티드 결합; GO:0001948 단백질 결합; ATP 결합; 크로마틴 결합; DNA클램프로더활성;
셀룰러 컴포넌트	염색체, 텔로미어 영역; Rad17 RFC와 같은 복합체; 핵; 핵소체; 핵소체;
생물학적 과정	유사분열세포주기체크포인트시그널링; DNA복제체크포인트시그널링; DNA복제; DNA손상체크포인트시그널링; 세포 주기; 인산화 조절; DNA복제부정조절; DNA 손상 자극에 대한 세포 반응; 유사분열 DNA 복제 체크포인트 시그널링; DNA복구; p53급 매개자에 의한 신호 전달 조절;
	출처:아미고 / QuickGO
맞춤법
	5884
	19356
	ENSG00000276618; ENSG00000152942
	ENSMUSG000021635
	O75943
	Q6NXW6
NM_001278622; NM_002873; NM_133338; NM_133339; NM_133340;
	NM_133341; NM_133342; NM_133343; NM_133344
	NM_001044371; NM_001283011; NM_011233
NP_00126551; NP_002864; NP_579916; NP_579917; NP_579918;
	NP_579919; NP_579920; NP_579921; NP_579922
	NP_001037836; NP_001269940; NP_035363
	위키데이터
인간 보기/편집	마우스 표시/편집

세포주기 체크포인트 단백질 RAD17은 RAD17 ^[5]^[6]유전자에 의해 인간에서 암호화되는 단백질이다.

기능.

이 유전자에 의해 코드된 단백질은 DNA 손상에 대한 반응으로 세포 주기 정지 및 DNA 손상 복구에 필요한 세포 주기 검사점 유전자인 Shychoscaromyces pombe rad17의 유전자 산물과 매우 유사하다.이 단백질은 DNA Replication Factor C(RFC; 복제 계수 C)와 매우 유사하며 RFC와 복합체를 형성할 수 있습니다.이 단백질은 DNA 손상 전에 염색질에 결합하고 손상 후 ATR에 의해 인산화된다.이 단백질은 DNA 손상 후 염색질에 RAD1-RAD9-HUS1 체크포인트 단백질 복합체를 모집하는데, 이는 인산화 시 필요할 수 있다.이 단백질의 인산화는 DNA 손상 유도 세포 주기 G2 정지에 필요하며, DNA 손상 세포에서 검사점 신호 전달 중에 중요한 초기 사건으로 생각됩니다.4개의 다른 단백질을 코드하는 이 유전자의 8개의 교대로 스플라이스된 전사 변형이 보고되었다.^[7]

상호 작용

RAD17은 다음과 상호작용하는 것으로 나타났습니다.

레퍼런스

^ ^a ^b ^c ENSG00000152942 GRCh38: 앙상블 릴리즈 89: ENSG00000276618, ENSG00000152942: Ensembl, 2017년 5월
^ ^a ^b ^c GRCm38: 앙상블 릴리즈 89: ENSMUSG000021635 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Bao S, Shen X, Shen K, Liu Y, Wang XF (March 1999). "The mammalian Rad24 homologous to yeast Saccharomyces cerevisiae Rad24 and Schizosaccharomyces pombe Rad17 is involved in DNA damage checkpoint". Cell Growth Differ. 9 (12): 961–7. PMID 9869296.
^ Parker AE, Van de Weyer I, Laus MC, Verhasselt P, Luyten WH (August 1998). "Identification of a human homologue of the Schizosaccharomyces pombe rad17+ checkpoint gene". J Biol Chem. 273 (29): 18340–6. doi:10.1074/jbc.273.29.18340. PMID 9660800.
^ "Entrez Gene: RAD17 RAD17 homolog (S. pombe)".
^ ^a ^b ^c Bao S, Tibbetts RS, Brumbaugh KM, Fang Y, Richardson DA, Ali A, Chen SM, Abraham RT, Wang XF (June 2001). "ATR/ATM-mediated phosphorylation of human Rad17 is required for genotoxic stress responses". Nature. 411 (6840): 969–74. Bibcode:2001Natur.411..969B. doi:10.1038/35082110. PMID 11418864. S2CID 4429058.
^ ^a ^b Kim ST, Lim DS, Canman CE, Kastan MB (Dec 1999). "Substrate specificities and identification of putative substrates of ATM kinase family members". J. Biol. Chem. 274 (53): 37538–43. doi:10.1074/jbc.274.53.37538. PMID 10608806.
^ ^a ^b ^c Bermudez VP, Lindsey-Boltz LA, Cesare AJ, Maniwa Y, Griffith JD, Hurwitz J, Sancar A (February 2003). "Loading of the human 9-1-1 checkpoint complex onto DNA by the checkpoint clamp loader hRad17-replication factor C complex in vitro". Proc. Natl. Acad. Sci. U.S.A. 100 (4): 1633–8. Bibcode:2003PNAS..100.1633B. doi:10.1073/pnas.0437927100. PMC 149884. PMID 12578958.
^ ^a ^b ^c Rauen M, Burtelow MA, Dufault VM, Karnitz LM (September 2000). "The human checkpoint protein hRad17 interacts with the PCNA-like proteins hRad1, hHus1, and hRad9". J. Biol. Chem. 275 (38): 29767–71. doi:10.1074/jbc.M005782200. PMID 10884395.
^ Chang MS, Sasaki H, Campbell MS, Kraeft SK, Sutherland R, Yang CY, Liu Y, Auclair D, Hao L, Sonoda H, Ferland LH, Chen LB (Dec 1999). "HRad17 colocalizes with NHP2L1 in the nucleolus and redistributes after UV irradiation". J. Biol. Chem. 274 (51): 36544–9. doi:10.1074/jbc.274.51.36544. PMID 10593953.
^ Post SM, Tomkinson AE, Lee EY (October 2003). "The human checkpoint Rad protein Rad17 is chromatin-associated throughout the cell cycle, localizes to DNA replication sites, and interacts with DNA polymerase epsilon". Nucleic Acids Res. 31 (19): 5568–75. doi:10.1093/nar/gkg765. PMC 206465. PMID 14500819.
^ Dufault VM, Oestreich AJ, Vroman BT, Karnitz LM (Dec 2003). "Identification and characterization of RAD9B, a paralog of the RAD9 checkpoint gene". Genomics. 82 (6): 644–51. doi:10.1016/s0888-7543(03)00200-3. PMID 14611806.
^ Lindsey-Boltz LA, Bermudez VP, Hurwitz J, Sancar A (September 2001). "Purification and characterization of human DNA damage checkpoint Rad complexes". Proc. Natl. Acad. Sci. U.S.A. 98 (20): 11236–41. Bibcode:2001PNAS...9811236L. doi:10.1073/pnas.201373498. PMC 58713. PMID 11572977.

추가 정보

Li L, Li HS, Pauza CD, Bukrinsky M, Zhao RY (2006). "Roles of HIV-1 auxiliary proteins in viral pathogenesis and host-pathogen interactions". Cell Res. 15 (11–12): 923–34. doi:10.1038/sj.cr.7290370. PMID 16354571.
al-Khodairy F, Carr AM (1992). "DNA repair mutants defining G2 checkpoint pathways in Schizosaccharomyces pombe". EMBO J. 11 (4): 1343–50. doi:10.1002/j.1460-2075.1992.tb05179.x. PMC 556583. PMID 1563350.
Mossi R, Jónsson ZO, Allen BL, Hardin SH, Hübscher U (1997). "Replication factor C interacts with the C-terminal side of proliferating cell nuclear antigen" (PDF). J. Biol. Chem. 272 (3): 1769–76. doi:10.1074/jbc.272.3.1769. PMID 8999859. S2CID 14454322.
Dean FB, Lian L, O'Donnell M (1999). "cDNA cloning and gene mapping of human homologs for Schizosaccharomyces pombe rad17, rad1, and hus1 and cloning of homologs from mouse, Caenorhabditis elegans, and Drosophila melanogaster". Genomics. 54 (3): 424–36. doi:10.1006/geno.1998.5587. PMID 9878245.
Bluyssen HA, Naus NC, van Os RI, Jaspers I, Hoeijmakers JH, de Klein A (1999). "Human and mouse homologs of the Schizosaccharomyces pombe rad17+ cell cycle checkpoint control gene". Genomics. 55 (2): 219–28. doi:10.1006/geno.1998.5642. PMID 9933569.
Li L, Peterson CA, Kanter-Smoler G, Wei YF, Ramagli LS, Sunnerhagen P, Siciliano MJ, Legerski RJ (1999). "hRAD17, a structural homolog of the Schizosaccharomyces pombe RAD17 cell cycle checkpoint gene, stimulates p53 accumulation". Oncogene. 18 (9): 1689–99. doi:10.1038/sj.onc.1202469. PMID 10208430.
Bao S, Chang MS, Auclair D, Sun Y, Wang Y, Wong WK, Zhang J, Liu Y, Qian X, Sutherland R, Magi-Galluzi C, Weisberg E, Cheng EY, Hao L, Sasaki H, Campbell MS, Kraeft SK, Loda M, Lo KM, Chen LB (1999). "HRad17, a human homologue of the Schizosaccharomyces pombe checkpoint gene rad17, is overexpressed in colon carcinoma". Cancer Res. 59 (9): 2023–8. PMID 10232579.
von Deimling F, Scharf JM, Liehr T, Rothe M, Kelter AR, Albers P, Dietrich WF, Kunkel LM, Wernert N, Wirth B (1999). "Human and mouse RAD17 genes: identification, localization, genomic structure and histological expression pattern in normal testis and seminoma". Hum. Genet. 105 (1–2): 17–27. doi:10.1007/s004390051058. PMID 10480350.
Chang MS, Sasaki H, Campbell MS, Kraeft SK, Sutherland R, Yang CY, Liu Y, Auclair D, Hao L, Sonoda H, Ferland LH, Chen LB (2000). "HRad17 colocalizes with NHP2L1 in the nucleolus and redistributes after UV irradiation". J. Biol. Chem. 274 (51): 36544–9. doi:10.1074/jbc.274.51.36544. PMID 10593953.
Kim ST, Lim DS, Canman CE, Kastan MB (2000). "Substrate specificities and identification of putative substrates of ATM kinase family members". J. Biol. Chem. 274 (53): 37538–43. doi:10.1074/jbc.274.53.37538. PMID 10608806.
Burtelow MA, Kaufmann SH, Karnitz LM (2000). "Retention of the human Rad9 checkpoint complex in extraction-resistant nuclear complexes after DNA damage". J. Biol. Chem. 275 (34): 26343–8. doi:10.1074/jbc.M001244200. PMID 10852904.
Rauen M, Burtelow MA, Dufault VM, Karnitz LM (2000). "The human checkpoint protein hRad17 interacts with the PCNA-like proteins hRad1, hHus1, and hRad9". J. Biol. Chem. 275 (38): 29767–71. doi:10.1074/jbc.M005782200. PMID 10884395.
Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
Bao S, Tibbetts RS, Brumbaugh KM, Fang Y, Richardson DA, Ali A, Chen SM, Abraham RT, Wang XF (2001). "ATR/ATM-mediated phosphorylation of human Rad17 is required for genotoxic stress responses". Nature. 411 (6840): 969–74. Bibcode:2001Natur.411..969B. doi:10.1038/35082110. PMID 11418864. S2CID 4429058.
Lindsey-Boltz LA, Bermudez VP, Hurwitz J, Sancar A (2001). "Purification and characterization of human DNA damage checkpoint Rad complexes". Proc. Natl. Acad. Sci. U.S.A. 98 (20): 11236–41. Bibcode:2001PNAS...9811236L. doi:10.1073/pnas.201373498. PMC 58713. PMID 11572977.
Chen MS, Higashikubo R, Laszlo A, Roti Roti J (2001). "Multiple alternative splicing forms of human RAD17 and their differential response to ionizing radiation". Gene. 277 (1–2): 145–52. doi:10.1016/S0378-1119(01)00692-8. PMID 11602352.
Post S, Weng YC, Cimprich K, Chen LB, Xu Y, Lee EY (2001). "Phosphorylation of serines 635 and 645 of human Rad17 is cell cycle regulated and is required for G1/S checkpoint activation in response to DNA damage". Proc. Natl. Acad. Sci. U.S.A. 98 (23): 13102–7. doi:10.1073/pnas.231364598. PMC 60831. PMID 11687627.

[refGRCh38Ensembl-1] ENSG00000152942 GRCh38: 앙상블 릴리즈 89: ENSG00000276618, ENSG00000152942: Ensembl, 2017년 5월

[refGRCm38Ensembl-2] GRCm38: 앙상블 릴리즈 89: ENSMUSG000021635 - 앙상블, 2017년 5월

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9869296-5] Bao S, Shen X, Shen K, Liu Y, Wang XF (March 1999). "The mammalian Rad24 homologous to yeast Saccharomyces cerevisiae Rad24 and Schizosaccharomyces pombe Rad17 is involved in DNA damage checkpoint". Cell Growth Differ. 9 (12): 961–7. PMID 9869296.

[pmid9660800-6] Parker AE, Van de Weyer I, Laus MC, Verhasselt P, Luyten WH (August 1998). "Identification of a human homologue of the Schizosaccharomyces pombe rad17+ checkpoint gene". J Biol Chem. 273 (29): 18340–6. doi:10.1074/jbc.273.29.18340. PMID 9660800.

[entrez-7] "Entrez Gene: RAD17 RAD17 homolog (S. pombe)".

[pmid11418864-8] Bao S, Tibbetts RS, Brumbaugh KM, Fang Y, Richardson DA, Ali A, Chen SM, Abraham RT, Wang XF (June 2001). "ATR/ATM-mediated phosphorylation of human Rad17 is required for genotoxic stress responses". Nature. 411 (6840): 969–74. Bibcode:2001Natur.411..969B. doi:10.1038/35082110. PMID 11418864. S2CID 4429058.

[pmid10608806-9] Kim ST, Lim DS, Canman CE, Kastan MB (Dec 1999). "Substrate specificities and identification of putative substrates of ATM kinase family members". J. Biol. Chem. 274 (53): 37538–43. doi:10.1074/jbc.274.53.37538. PMID 10608806.

[pmid12578958-10] Bermudez VP, Lindsey-Boltz LA, Cesare AJ, Maniwa Y, Griffith JD, Hurwitz J, Sancar A (February 2003). "Loading of the human 9-1-1 checkpoint complex onto DNA by the checkpoint clamp loader hRad17-replication factor C complex in vitro". Proc. Natl. Acad. Sci. U.S.A. 100 (4): 1633–8. Bibcode:2003PNAS..100.1633B. doi:10.1073/pnas.0437927100. PMC 149884. PMID 12578958.

[pmid10884395-11] Rauen M, Burtelow MA, Dufault VM, Karnitz LM (September 2000). "The human checkpoint protein hRad17 interacts with the PCNA-like proteins hRad1, hHus1, and hRad9". J. Biol. Chem. 275 (38): 29767–71. doi:10.1074/jbc.M005782200. PMID 10884395.

[pmid10593953-12] Chang MS, Sasaki H, Campbell MS, Kraeft SK, Sutherland R, Yang CY, Liu Y, Auclair D, Hao L, Sonoda H, Ferland LH, Chen LB (Dec 1999). "HRad17 colocalizes with NHP2L1 in the nucleolus and redistributes after UV irradiation". J. Biol. Chem. 274 (51): 36544–9. doi:10.1074/jbc.274.51.36544. PMID 10593953.

[pmid14500819-13] Post SM, Tomkinson AE, Lee EY (October 2003). "The human checkpoint Rad protein Rad17 is chromatin-associated throughout the cell cycle, localizes to DNA replication sites, and interacts with DNA polymerase epsilon". Nucleic Acids Res. 31 (19): 5568–75. doi:10.1093/nar/gkg765. PMC 206465. PMID 14500819.

[pmid14611806-14] Dufault VM, Oestreich AJ, Vroman BT, Karnitz LM (Dec 2003). "Identification and characterization of RAD9B, a paralog of the RAD9 checkpoint gene". Genomics. 82 (6): 644–51. doi:10.1016/s0888-7543(03)00200-3. PMID 14611806.

[pmid11572977-15] Lindsey-Boltz LA, Bermudez VP, Hurwitz J, Sancar A (September 2001). "Purification and characterization of human DNA damage checkpoint Rad complexes". Proc. Natl. Acad. Sci. U.S.A. 98 (20): 11236–41. Bibcode:2001PNAS...9811236L. doi:10.1073/pnas.201373498. PMC 58713. PMID 11572977.

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Search

RAD17

네임스페이스

더

목차

기능.

상호 작용

레퍼런스

추가 정보