HUS1

HUS1
사용 가능한 구조
PDB	Ortholog 검색: PDBe RCSB
PDB ID 코드 목록
	3A1J, 3G65, 3GGR
식별자
에일리어스	HUS1, hHUS1 체크포인트 클램프 구성 요소
외부 ID	OMIM: 603760 MGI: 1277962 HomoloGene: 37932 GenCard: HUS1
유전자 위치(인간)
크르.	7번 염색체(인간)
끝.	47,979,615 bp
유전자 위치(마우스)
크르.	11번 염색체(쥐)
끝.	8,961,191 bp
RNA발현패턴
	상단 표시 위치:
	단구; ; 상부 신경; ; 아킬레스건; ; 랑게르한스 섬; ; 직장; ; 위근; ; 자궁내막간질세포; ; 좌부신; ; 좌심실; ; 신경절 융기;
	추가 참조 표현식 데이터
	; ; ; ;
	추가 참조 표현식 데이터
유전자 존재론
분자 함수	GO:0001948 단백질 결합;
셀룰러 컴포넌트	이중 파단부위; 세포질; 세포; 핵소체; 체크 포인트 클램프 복합체; 핵소체; 핵;
생물학적 과정	단백질인산화조절; 뉴클레오티드 절제 회복; 감수생물학적 DNA 무결성 체크포인트 시그널링; 배아의 발달; 유사분열세포주기체크포인트시그널링; 유사분열성 S내 DNA손상 체크포인트 시그널링; DNA복제부정조절; DNA 손상 자극에 대한 세포 반응; 단백질인산화; 유사분열 DNA 복제 체크포인트 시그널링; 이온화 방사선에 대한 세포 반응; 자외선에 대한 반응; 상동 재조합에 의한 이중 파단 수리; DNA손상체크포인트시그널링; DNA복구; 출생 또는 부화로 끝나는 배아 발달; 텔로미어 유지; DNA복제; p53급 매개자에 의한 신호 전달 조절;
	출처:아미고 / QuickGO
맞춤법
	3364
	15574
	ENSG00000136273
	ENSMUSG000020413
	O60921
	Q8BQY8
	NM_004507; NM_001363683
	NM_008316; NM_001303532; NM_001303610
	NP_004498; NP_001350612
	NP_001290461; NP_001290539; NP_032342
	위키데이터
인간 보기/편집	마우스 표시/편집

체크포인트 단백질 HUS1은 인체에서 HUS1 유전자에 ^[5]^[6]의해 암호화되는 단백질이다.

기능.

이 유전자에 의해 암호화된 단백질은 DNA 손상에 대한 반응으로 세포 주기 정지에 관여하는 진화적으로 보존된, 제노톡신 활성화 체크포인트 복합체의 구성요소이다.이 단백질은 체크포인트 단백질 RAD9 및 RAD1과 헤테로 이성질체 복합체를 형성한다.DNA 손상에 대한 응답으로 삼량체 복합체는 체크포인트 단백질 RAD17 및 복합체를 크로마틴에 로드하는 복제인자 C(RFC)의 4개의 작은 서브유닛으로 이루어진 또 다른 단백질 복합체와 상호작용한다.DNA 손상 유도 크로마틴 결합은 체크포인트 키나제 ATM의 활성화에 따라 달라지는 것으로 나타났으며, 초기 체크포인트 ^[7]시그널링 이벤트로 생각된다.

상호 작용

HUS1은 다음과 상호작용하는 것으로 나타났습니다.

레퍼런스

^ ^a ^b ^c GRCh38: 앙상블 릴리즈 89: ENSG00000136273 - 앙상블, 2017년 5월
^ ^a ^b ^c GRCm38: 앙상블 릴리즈 89: ENSMUSG000020413 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Dean FB, Lian L, O'Donnell M (Dec 1998). "cDNA cloning and gene mapping of human homologs for Schizosaccharomyces pombe rad17, rad1, and hus1 and cloning of homologs from mouse, Caenorhabditis elegans, and Drosophila melanogaster". Genomics. 54 (3): 424–36. doi:10.1006/geno.1998.5587. PMID 9878245.
^ Kostrub CF, Knudsen K, Subramani S, Enoch T (Apr 1998). "Hus1p, a conserved fission yeast checkpoint protein, interacts with Rad1p and is phosphorylated in response to DNA damage". The EMBO Journal. 17 (7): 2055–66. doi:10.1093/emboj/17.7.2055. PMC 1170550. PMID 9524127.
^ "Entrez Gene: HUS1 HUS1 checkpoint homolog (S. pombe)".
^ Cai RL, Yan-Neale Y, Cueto MA, Xu H, Cohen D (Sep 2000). "HDAC1, a histone deacetylase, forms a complex with Hus1 and Rad9, two G2/M checkpoint Rad proteins". The Journal of Biological Chemistry. 275 (36): 27909–16. doi:10.1074/jbc.M000168200. PMID 10846170.
^ Komatsu K, Wharton W, Hang H, Wu C, Singh S, Lieberman HB, Pledger WJ, Wang HG (Nov 2000). "PCNA interacts with hHus1/hRad9 in response to DNA damage and replication inhibition". Oncogene. 19 (46): 5291–7. doi:10.1038/sj.onc.1203901. PMID 11077446. S2CID 8931364.
^ ^a ^b Volkmer E, Karnitz LM (Jan 1999). "Human homologs of Schizosaccharomyces pombe rad1, hus1, and rad9 form a DNA damage-responsive protein complex". The Journal of Biological Chemistry. 274 (2): 567–70. doi:10.1074/jbc.274.2.567. PMID 9872989. S2CID 28787137.
^ Hang H, Zhang Y, Dunbrack RL, Wang C, Lieberman HB (Apr 2002). "Identification and characterization of a paralog of human cell cycle checkpoint gene HUS1". Genomics. 79 (4): 487–92. doi:10.1006/geno.2002.6737. PMID 11944979.
^ Bermudez VP, Lindsey-Boltz LA, Cesare AJ, Maniwa Y, Griffith JD, Hurwitz J, Sancar A (Feb 2003). "Loading of the human 9-1-1 checkpoint complex onto DNA by the checkpoint clamp loader hRad17-replication factor C complex in vitro". Proceedings of the National Academy of Sciences of the United States of America. 100 (4): 1633–8. doi:10.1073/pnas.0437927100. PMC 149884. PMID 12578958.
^ Rauen M, Burtelow MA, Dufault VM, Karnitz LM (Sep 2000). "The human checkpoint protein hRad17 interacts with the PCNA-like proteins hRad1, hHus1, and hRad9". The Journal of Biological Chemistry. 275 (38): 29767–71. doi:10.1074/jbc.M005782200. PMID 10884395. S2CID 34505615.
^ Dufault VM, Oestreich AJ, Vroman BT, Karnitz LM (Dec 2003). "Identification and characterization of RAD9B, a paralog of the RAD9 checkpoint gene". Genomics. 82 (6): 644–51. doi:10.1016/s0888-7543(03)00200-3. PMID 14611806.
^ Griffith JD, Lindsey-Boltz LA, Sancar A (May 2002). "Structures of the human Rad17-replication factor C and checkpoint Rad 9-1-1 complexes visualized by glycerol spray/low voltage microscopy". The Journal of Biological Chemistry. 277 (18): 15233–6. doi:10.1074/jbc.C200129200. PMID 11907025. S2CID 24820773.
^ Hirai I, Wang HG (Jul 2002). "A role of the C-terminal region of human Rad9 (hRad9) in nuclear transport of the hRad9 checkpoint complex". The Journal of Biological Chemistry. 277 (28): 25722–7. doi:10.1074/jbc.M203079200. PMID 11994305. S2CID 35202138.

추가 정보

Dominguez O, Ashhab Y, Sabater L, Belloso E, Caro P, Pujol-Borrell R (Dec 1998). "Cloning of ARE-containing genes by AU-motif-directed display". Genomics. 54 (2): 278–86. doi:10.1006/geno.1998.5548. PMID 9828130.
Volkmer E, Karnitz LM (Jan 1999). "Human homologs of Schizosaccharomyces pombe rad1, hus1, and rad9 form a DNA damage-responsive protein complex". The Journal of Biological Chemistry. 274 (2): 567–70. doi:10.1074/jbc.274.2.567. PMID 9872989. S2CID 28787137.
St Onge RP, Udell CM, Casselman R, Davey S (Jun 1999). "The human G2 checkpoint control protein hRAD9 is a nuclear phosphoprotein that forms complexes with hRAD1 and hHUS1". Molecular Biology of the Cell. 10 (6): 1985–95. doi:10.1091/mbc.10.6.1985. PMC 25401. PMID 10359610.
Hang H, Lieberman HB (Apr 2000). "Physical interactions among human checkpoint control proteins HUS1p, RAD1p, and RAD9p, and implications for the regulation of cell cycle progression". Genomics. 65 (1): 24–33. doi:10.1006/geno.2000.6142. PMID 10777662.
Cai RL, Yan-Neale Y, Cueto MA, Xu H, Cohen D (Sep 2000). "HDAC1, a histone deacetylase, forms a complex with Hus1 and Rad9, two G2/M checkpoint Rad proteins". The Journal of Biological Chemistry. 275 (36): 27909–16. doi:10.1074/jbc.M000168200. PMID 10846170.
Burtelow MA, Kaufmann SH, Karnitz LM (Aug 2000). "Retention of the human Rad9 checkpoint complex in extraction-resistant nuclear complexes after DNA damage". The Journal of Biological Chemistry. 275 (34): 26343–8. doi:10.1074/jbc.M001244200. PMID 10852904. S2CID 24638557.
Rauen M, Burtelow MA, Dufault VM, Karnitz LM (Sep 2000). "The human checkpoint protein hRad17 interacts with the PCNA-like proteins hRad1, hHus1, and hRad9". The Journal of Biological Chemistry. 275 (38): 29767–71. doi:10.1074/jbc.M005782200. PMID 10884395. S2CID 34505615.
Komatsu K, Wharton W, Hang H, Wu C, Singh S, Lieberman HB, Pledger WJ, Wang HG (Nov 2000). "PCNA interacts with hHus1/hRad9 in response to DNA damage and replication inhibition". Oncogene. 19 (46): 5291–7. doi:10.1038/sj.onc.1203901. PMID 11077446. S2CID 8931364.
Xiang SL, Kumano T, Iwasaki SI, Sun X, Yoshioka K, Yamamoto KC (Oct 2001). "The J domain of Tpr2 regulates its interaction with the proapoptotic and cell-cycle checkpoint protein, Rad9". Biochemical and Biophysical Research Communications. 287 (4): 932–40. doi:10.1006/bbrc.2001.5685. hdl:2297/1794. PMID 11573955.
Griffith JD, Lindsey-Boltz LA, Sancar A (May 2002). "Structures of the human Rad17-replication factor C and checkpoint Rad 9-1-1 complexes visualized by glycerol spray/low voltage microscopy". The Journal of Biological Chemistry. 277 (18): 15233–6. doi:10.1074/jbc.C200129200. PMID 11907025. S2CID 24820773.
Kinzel B, Hall J, Natt F, Weiler J, Cohen D (Mar 2002). "Downregulation of Hus1 by antisense oligonucleotides enhances the sensitivity of human lung carcinoma cells to cisplatin". Cancer. 94 (6): 1808–14. doi:10.1002/cncr.10383. PMID 11920544. S2CID 21518094.
Hang H, Zhang Y, Dunbrack RL, Wang C, Lieberman HB (Apr 2002). "Identification and characterization of a paralog of human cell cycle checkpoint gene HUS1". Genomics. 79 (4): 487–92. doi:10.1006/geno.2002.6737. PMID 11944979.
Roos-Mattjus P, Vroman BT, Burtelow MA, Rauen M, Eapen AK, Karnitz LM (Nov 2002). "Genotoxin-induced Rad9-Hus1-Rad1 (9-1-1) chromatin association is an early checkpoint signaling event". The Journal of Biological Chemistry. 277 (46): 43809–12. doi:10.1074/jbc.M207272200. PMID 12228248. S2CID 24728793.
Bermudez VP, Lindsey-Boltz LA, Cesare AJ, Maniwa Y, Griffith JD, Hurwitz J, Sancar A (Feb 2003). "Loading of the human 9-1-1 checkpoint complex onto DNA by the checkpoint clamp loader hRad17-replication factor C complex in vitro". Proceedings of the National Academy of Sciences of the United States of America. 100 (4): 1633–8. doi:10.1073/pnas.0437927100. PMC 149884. PMID 12578958.
Hopkins KM, Wang X, Berlin A, Hang H, Thaker HM, Lieberman HB (Sep 2003). "Expression of mammalian paralogues of HRAD9 and Mrad9 checkpoint control genes in normal and cancerous testicular tissue". Cancer Research. 63 (17): 5291–8. PMID 14500360.
Dufault VM, Oestreich AJ, Vroman BT, Karnitz LM (Dec 2003). "Identification and characterization of RAD9B, a paralog of the RAD9 checkpoint gene". Genomics. 82 (6): 644–51. doi:10.1016/S0888-7543(03)00200-3. PMID 14611806.

[refGRCh38Ensembl-1] GRCh38: 앙상블 릴리즈 89: ENSG00000136273 - 앙상블, 2017년 5월

[refGRCm38Ensembl-2] GRCm38: 앙상블 릴리즈 89: ENSMUSG000020413 - 앙상블, 2017년 5월

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9878245-5] Dean FB, Lian L, O'Donnell M (Dec 1998). "cDNA cloning and gene mapping of human homologs for Schizosaccharomyces pombe rad17, rad1, and hus1 and cloning of homologs from mouse, Caenorhabditis elegans, and Drosophila melanogaster". Genomics. 54 (3): 424–36. doi:10.1006/geno.1998.5587. PMID 9878245.

[pmid9524127-6] Kostrub CF, Knudsen K, Subramani S, Enoch T (Apr 1998). "Hus1p, a conserved fission yeast checkpoint protein, interacts with Rad1p and is phosphorylated in response to DNA damage". The EMBO Journal. 17 (7): 2055–66. doi:10.1093/emboj/17.7.2055. PMC 1170550. PMID 9524127.

[entrez-7] "Entrez Gene: HUS1 HUS1 checkpoint homolog (S. pombe)".

[pmid10846170-8] Cai RL, Yan-Neale Y, Cueto MA, Xu H, Cohen D (Sep 2000). "HDAC1, a histone deacetylase, forms a complex with Hus1 and Rad9, two G2/M checkpoint Rad proteins". The Journal of Biological Chemistry. 275 (36): 27909–16. doi:10.1074/jbc.M000168200. PMID 10846170.

[pmid11077446-9] Komatsu K, Wharton W, Hang H, Wu C, Singh S, Lieberman HB, Pledger WJ, Wang HG (Nov 2000). "PCNA interacts with hHus1/hRad9 in response to DNA damage and replication inhibition". Oncogene. 19 (46): 5291–7. doi:10.1038/sj.onc.1203901. PMID 11077446. S2CID 8931364.

[pmid9872989-10] Volkmer E, Karnitz LM (Jan 1999). "Human homologs of Schizosaccharomyces pombe rad1, hus1, and rad9 form a DNA damage-responsive protein complex". The Journal of Biological Chemistry. 274 (2): 567–70. doi:10.1074/jbc.274.2.567. PMID 9872989. S2CID 28787137.

[pmid11944979-11] Hang H, Zhang Y, Dunbrack RL, Wang C, Lieberman HB (Apr 2002). "Identification and characterization of a paralog of human cell cycle checkpoint gene HUS1". Genomics. 79 (4): 487–92. doi:10.1006/geno.2002.6737. PMID 11944979.

[pmid12578958-12] Bermudez VP, Lindsey-Boltz LA, Cesare AJ, Maniwa Y, Griffith JD, Hurwitz J, Sancar A (Feb 2003). "Loading of the human 9-1-1 checkpoint complex onto DNA by the checkpoint clamp loader hRad17-replication factor C complex in vitro". Proceedings of the National Academy of Sciences of the United States of America. 100 (4): 1633–8. doi:10.1073/pnas.0437927100. PMC 149884. PMID 12578958.

[pmid10884395-13] Rauen M, Burtelow MA, Dufault VM, Karnitz LM (Sep 2000). "The human checkpoint protein hRad17 interacts with the PCNA-like proteins hRad1, hHus1, and hRad9". The Journal of Biological Chemistry. 275 (38): 29767–71. doi:10.1074/jbc.M005782200. PMID 10884395. S2CID 34505615.

[pmid14611806-14] Dufault VM, Oestreich AJ, Vroman BT, Karnitz LM (Dec 2003). "Identification and characterization of RAD9B, a paralog of the RAD9 checkpoint gene". Genomics. 82 (6): 644–51. doi:10.1016/s0888-7543(03)00200-3. PMID 14611806.

[pmid11907025-15] Griffith JD, Lindsey-Boltz LA, Sancar A (May 2002). "Structures of the human Rad17-replication factor C and checkpoint Rad 9-1-1 complexes visualized by glycerol spray/low voltage microscopy". The Journal of Biological Chemistry. 277 (18): 15233–6. doi:10.1074/jbc.C200129200. PMID 11907025. S2CID 24820773.

[pmid11994305-16] Hirai I, Wang HG (Jul 2002). "A role of the C-terminal region of human Rad9 (hRad9) in nuclear transport of the hRad9 checkpoint complex". The Journal of Biological Chemistry. 277 (28): 25722–7. doi:10.1074/jbc.M203079200. PMID 11994305. S2CID 35202138.

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Search

HUS1

네임스페이스

더

목차

기능.

상호 작용

레퍼런스

추가 정보