PPP1R13L

PPP1R13L
사용 가능한 구조물
PDB	직교 검색: PDBe RCSB
PDB ID 코드 목록
	2VGE
식별자
별칭	PPP1R13L, IASPP, NKIP1, RAI, RAI4, 단백질인산효소 1 규제부위 13은 다음과 같다.
외부 ID	OMIM: 607463 MGI: 3525053 호몰로진: 84635 GeneCard: PPP1R13L
유전자 위치(인간)
쳇.	19번 염색체(인간)
끝	45,406,190 bp
유전자 위치(마우스)
쳇.	7번 염색체(쥐)
끝	19,1968,458 bp
RNA 표현 패턴
	표현된 상단
	좌심실; ; 질질 끌다; ; 피부 영역;
	추가 참조 표현식 데이터
	추가 참조 표현식 데이터
유전자 온톨로지
분자함수	전사 계수 바인딩; GO:0001948 단백질 결합; GO:0001106 전사 코어프레스터 활동; 동일한 단백질 결합; 캐더린 제본;
셀룰러 컴포넌트	세포 접합; 핵의; 세포간 교량; 핵종의; 세포질; 시토솔;
생물학적 과정	배아 카메라형 안구 발달; 헤어 사이클; 심실 심장근육조직 발달; 전사 규정, DNA-템플링; RNA 중합효소 II에 의한 전사의 음성 조절; 심장우심실모형생성; 후기 개발; 다세포 유기체 자기중심성; 심장근육수축; 세포 분화의 긍정적인 조절; 전사, DNA-템플릿; 다세포 유기체 성장; 사멸적 과정; p53 등급 중재자에 의한 신호전송 규제;
	출처:아미고 / 퀵고
직교체
	10848
	333654
	ENSG00000104881
	ENSMUSG00000040734
	Q8WUF5
	Q5I1X5
	NM_00663; NM_001142502
	NM_001010836
	NP_001135974; NP_006654
	NP_001010836
	위키다타
인간 보기/편집	마우스 보기/편집

RelA 관련 억제제는 인간에서 PPP1R13L 유전자에 의해 인코딩되는 단백질이다.^[5]^[6]

상호작용

PPP1R13L는 Sp1 전사 계수^[7] 및 RELA와 상호작용하는 것으로 나타났다.^[5]^[7]

참조

^ ^a ^b ^c GRCh38: 앙상블 릴리스 89: ENSG00000104881 - 앙상블, 2017년 5월
^ ^a ^b ^c GRCm38: 앙상블 릴리스 89: ENSMUSG000040734 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b Yang JP, Hori M, Sanda T, Okamoto T (May 1999). "Identification of a novel inhibitor of nuclear factor-kappaB, RelA-associated inhibitor". The Journal of Biological Chemistry. 274 (22): 15662–70. doi:10.1074/jbc.274.22.15662. PMID 10336463.
^ "Entrez Gene: PPP1R13L protein phosphatase 1, regulatory (inhibitor) subunit 13 like".
^ ^a ^b Takada N, Sanda T, Okamoto H, Yang JP, Asamitsu K, Sarol L, Kimura G, Uranishi H, Tetsuka T, Okamoto T (August 2002). "RelA-associated inhibitor blocks transcription of human immunodeficiency virus type 1 by inhibiting NF-kappaB and Sp1 actions". Journal of Virology. 76 (16): 8019–30. doi:10.1128/JVI.76.16.8019-8030.2002. PMC 155123. PMID 12134007.

추가 읽기

Liu ZJ, Lu X, Zhong S (September 2005). "ASPP--Apoptotic specific regulator of p53". Biochimica et Biophysica Acta (BBA) - Reviews on Cancer. 1756 (1): 77–80. doi:10.1016/j.bbcan.2005.08.002. PMID 16139958.
Takada N, Sanda T, Okamoto H, Yang JP, Asamitsu K, Sarol L, Kimura G, Uranishi H, Tetsuka T, Okamoto T (August 2002). "RelA-associated inhibitor blocks transcription of human immunodeficiency virus type 1 by inhibiting NF-kappaB and Sp1 actions". Journal of Virology. 76 (16): 8019–30. doi:10.1128/JVI.76.16.8019-8030.2002. PMC 155123. PMID 12134007.
Bergamaschi D, Samuels Y, O'Neil NJ, Trigiante G, Crook T, Hsieh JK, O'Connor DJ, Zhong S, Campargue I, Tomlinson ML, Kuwabara PE, Lu X (February 2003). "iASPP oncoprotein is a key inhibitor of p53 conserved from worm to human". Nature Genetics. 33 (2): 162–7. doi:10.1038/ng1070. PMID 12524540. S2CID 22841392.
Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM (July 2004). "Functional proteomics mapping of a human signaling pathway". Genome Research. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
Slee EA, Gillotin S, Bergamaschi D, Royer C, Llanos S, Ali S, Jin B, Trigiante G, Lu X (December 2004). "The N-terminus of a novel isoform of human iASPP is required for its cytoplasmic localization". Oncogene. 23 (56): 9007–16. doi:10.1038/sj.onc.1208088. PMID 15489900.
Issaeva N, Bozko P, Enge M, Protopopova M, Verhoef LG, Masucci M, Pramanik A, Selivanova G (December 2004). "Small molecule RITA binds to p53, blocks p53-HDM-2 interaction and activates p53 function in tumors". Nature Medicine. 10 (12): 1321–8. doi:10.1038/nm1146. PMID 15558054. S2CID 82043.
Zhang X, Wang M, Zhou C, Chen S, Wang J (February 2005). "The expression of iASPP in acute leukemias". Leukemia Research. 29 (2): 179–83. doi:10.1016/j.leukres.2004.07.001. PMID 15607367.
Laska MJ, Nexø BA, Vistisen K, Poulsen HE, Loft S, Vogel U (July 2005). "Polymorphisms in RAI and in genes of nucleotide and base excision repair are not associated with risk of testicular cancer". Cancer Letters. 225 (2): 245–51. doi:10.1016/j.canlet.2005.03.021. PMID 15885892.
Skjelbred CF, Saebø M, Nexø BA, Wallin H, Hansteen IL, Vogel U, Kure EH (July 2006). "Effects of polymorphisms in ERCC1, ASE-1 and RAI on the risk of colorectal carcinomas and adenomas: a case control study". BMC Cancer. 6: 175. doi:10.1186/1471-2407-6-175. PMC 1533843. PMID 16817948.
Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (October 2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nature Biotechnology. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
Bergamaschi D, Samuels Y, Sullivan A, Zvelebil M, Breyssens H, Bisso A, Del Sal G, Syed N, Smith P, Gasco M, Crook T, Lu X (October 2006). "iASPP preferentially binds p53 proline-rich region and modulates apoptotic function of codon 72-polymorphic p53". Nature Genetics. 38 (10): 1133–41. doi:10.1038/ng1879. PMID 16964264. S2CID 27662568.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (November 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
Zhang X, Diao S, Rao Q, Xing H, Liu H, Liao X, Wang M, Wang J (May 2007). "Identification of a novel isoform of iASPP and its interaction with p53". Journal of Molecular Biology. 368 (4): 1162–71. doi:10.1016/j.jmb.2007.03.001. PMID 17391696.
Laska MJ, Strandbygård D, Kjeldgaard A, Mains M, Corydon TJ, Memon AA, Sørensen BS, Vogel U, Jensen UB, Nexø BA (July 2007). "Expression of the RAI gene is conducive to apoptosis: studies of induction and interference". Experimental Cell Research. 313 (12): 2611–21. doi:10.1016/j.yexcr.2007.05.006. PMID 17570360.

19번 염색체의 유전자에 관한 이 기사는 단조롭다.위키피디아를 확장하여 도울 수 있다.

[refGRCh38Ensembl-1] GRCh38: 앙상블 릴리스 89: ENSG00000104881 - 앙상블, 2017년 5월

[refGRCm38Ensembl-2] GRCm38: 앙상블 릴리스 89: ENSMUSG000040734 - 앙상블, 2017년 5월

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10336463-5] Yang JP, Hori M, Sanda T, Okamoto T (May 1999). "Identification of a novel inhibitor of nuclear factor-kappaB, RelA-associated inhibitor". The Journal of Biological Chemistry. 274 (22): 15662–70. doi:10.1074/jbc.274.22.15662. PMID 10336463.

[entrez-6] "Entrez Gene: PPP1R13L protein phosphatase 1, regulatory (inhibitor) subunit 13 like".

[pmid12134007-7] Takada N, Sanda T, Okamoto H, Yang JP, Asamitsu K, Sarol L, Kimura G, Uranishi H, Tetsuka T, Okamoto T (August 2002). "RelA-associated inhibitor blocks transcription of human immunodeficiency virus type 1 by inhibiting NF-kappaB and Sp1 actions". Journal of Virology. 76 (16): 8019–30. doi:10.1128/JVI.76.16.8019-8030.2002. PMC 155123. PMID 12134007.

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PPP1R13L

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