PDZ 도메인 함유 단백질 2는, 인간내 에서 PDZD2 [5] [6] 단백질 이다.
기능. PDZ 도메인 을 포함하는 단백질은 트랜스막 수용체 또는 이온 채널의 C-termini와 결합하는 것으로 자주 나타났다.그들은 또한 다른 PDZ 도메인 단백질과 결합하는 것으로 보여졌으며 세포 내 신호 전달에 관여할 수 있다. 이 유전자에 의해 암호화된 단백질은 6개의 PDZ 도메인을 포함하고 있으며 프로-인터류킨-16(pro-IL-16)과 배열 유사성을 공유한다. pro-IL-16과 마찬가지로 코드화된 단백질은 내소체 망막에 국재하여 카스파아제에 의해 분해되어 2개의 PDZ 도메인을 포함한 분비펩타이드를 생성하는 것으로 생각된다. 또한, 이 유전자는 원발성 전립선 종양에서 상향 조절되며 전립선 종양 [6]
상호 작용 PDZD2는 PKP4 와 [7] [8] 것 으로 나타났습니다.
레퍼런스 ^ a b c GRCh38: 앙상블 릴리즈 89: ENSG00000133401 - 앙상블 , 2017년 5월^ a b c GRCm38: 앙상블 릴리즈 89: ENSMUSG000022197 - 앙상블 , 2017년 5월^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Nagase T, Ishikawa K, Nakajima D, Ohira M, Seki N, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (September 1997). "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro" . DNA Res . 4 (2): 141–50. doi :10.1093/dnares/4.2.141 PMID 9205841 . ^ a b "Entrez Gene: PDZD2 PDZ domain containing 2" .^ Deguchi M, Iizuka T, Hata Y, Nishimura W, Hirao K, Yao I, Kawabe H, Takai Y (September 2000). "PAPIN. A novel multiple PSD-95/Dlg-A/ZO-1 protein interacting with neural plakophilin-related armadillo repeat protein/delta-catenin and p0071" . J. Biol. Chem . 275 (38): 29875–80. doi :10.1074/jbc.M005384200 PMID 10896674 . ^ Ohno H, Hirabayashi S, Iizuka T, Ohnishi H, Fujita T, Hata Y (October 2002). "Localization of p0071-interacting proteins, plakophilin-related armadillo-repeat protein-interacting protein (PAPIN) and ERBIN, in epithelial cells" . Oncogene . 21 (46): 7042–9. doi :10.1038/sj.onc.1205852 PMID 12370826 . 추가 정보 Lindahl P, Abrahamson M, Björk I (1992). "Interaction of recombinant human cystatin C with the cysteine proteinases papain and actinidin" . Biochem. J . 281 ( Pt 1) (Pt 1): 49–55. doi :10.1042/bj2810049 . PMC 1130639 PMID 1731767 . Bonaldo MF, Lennon G, Soares MB (1996). "Normalization and subtraction: two approaches to facilitate gene discovery" . Genome Res . 6 (9): 791–806. doi :10.1101/gr.6.9.791 PMID 8889548 . Deguchi M, Iizuka T, Hata Y, Nishimura W, Hirao K, Yao I, Kawabe H, Takai Y (2000). "PAPIN. A novel multiple PSD-95/Dlg-A/ZO-1 protein interacting with neural plakophilin-related armadillo repeat protein/delta-catenin and p0071" . J. Biol. Chem . 275 (38): 29875–80. doi :10.1074/jbc.M005384200 PMID 10896674 . Chaib H, Rubin MA, Mucci NR, Li L, Day ML, Rhim JS, Macoska JA (2001). "Activated in prostate cancer: a PDZ domain-containing protein highly expressed in human primary prostate tumors". Cancer Res . 61 (6): 2390–4. PMID 11289102 . Ohno H, Hirabayashi S, Iizuka T, Ohnishi H, Fujita T, Hata Y (2002). "Localization of p0071-interacting proteins, plakophilin-related armadillo-repeat protein-interacting protein (PAPIN) and ERBIN, in epithelial cells" . Oncogene . 21 (46): 7042–9. doi :10.1038/sj.onc.1205852 PMID 12370826 . Nakayama M, Kikuno R, Ohara O (2002). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs" . Genome Res . 12 (11): 1773–84. doi :10.1101/gr.406902 . PMC 187542 PMID 12421765 . Yeung ML, Tam TS, Tsang AC, Yao KM (2003). "Proteolytic cleavage of PDZD2 generates a secreted peptide containing two PDZ domains" . EMBO Rep . 4 (4): 412–8. doi :10.1038/sj.embor.embor804 . PMC 1319160 PMID 12671685 . Ma RY, Tam TS, Suen AP, Yeung PM, Tsang SW, Chung SK, Thomas MK, Leung PS, Yao KM (2006). "Secreted PDZD2 exerts concentration-dependent effects on the proliferation of INS-1E cells". Int. J. Biochem. Cell Biol . 38 (5–6): 1015–22. doi :10.1016/j.biocel.2005.11.012 . PMID 16413998 .
