플라코필린-4

PKP4
식별자
에일리어스	PKP4, p0071, 플라코필린 4
외부 ID	OMIM : 604276 MGI : 109281 HomoloGene : 2689 GenCard : PKP4
유전자 위치(인간)
크르.	2번 염색체(인간)
끝.	158,682,879 bp
유전자 위치(마우스)
크르.	2번 염색체(마우스)
끝.	59,355,194 bp
RNA발현패턴
	상단 표시 위치:
	미주신경의 하부 신경절; ; 내장글로부페리더스; ; 뇌량; ; 시상하핵; ; 부고환 카푸트; ; 편도체; ; 창호; ; 중전두회; ; 시상하부; ; 미산핵;
	상단 표시 위치:
	섬모체; ; 홍채; ; 흑색 실체; ; 해마의 고유 영역 I; ; 상행 대동맥; ; 운동 뉴런; ; 편도체; ; 턱밑샘; ; 글로부스페리더스; ; 대상회;
	추가 참조 표현식 데이터
	; ; ; ;
	추가 참조 표현식 데이터
유전자 존재론
분자 함수	단백질 결합; 카드헤린 결합;
셀룰러 컴포넌트	세포질; 스핀들 폴; 막; 시냅스 후 밀도; 세포 접촉대; 세포-세포 접합; 스핀들; 데스모솜; 세포 접합; 미드바디; 방추체 중간대; 세포질핵주위영역; 혈장막세포질측; 유사분열 방추; 세포골격; 각질 봉투; 혈장막; 핵;
생물학적 과정	세포신호; 사이토키네시스 양성 조절; GTPase 활성의 양성 조절; 세포유착조절; 세포 접착; 세포접합조립체; 케라티네이션; 옥수수화; 세포 접착;
	출처:아미고 / QuickGO
맞춤법
	8502
	227937
	ENSG00000144283
	ENSMUSG000026991
	Q99569
	Q68FH0
NM_001005476; NM_001304969; NM_001304970; NM_001304971; NM_003628;
	NM_001377218; NM_001377219; NM_001377220; NM_001377221; NM_001377222; NM_001377223; NM_001377224; NM_001377225; NM_001377226
NM_026361; NM_175464; NM_001362990; NM_001362991; NM_001362992;
	NM_001362993; NM_001362994; NM_001362995; NM_001362996; NM_001362997; NM_001362998; NM_001362999
NP_001005476; NP_001291898; NP_001291899; NP_001291900; NP_003619;
	NP_001364147; NP_001364148; NP_001364149; NP_001364150; NP_001364151; NP_001364152; NP_001364153; NP_001364154; NP_001364155
NP_080637; NP_780673; NP_001349919; NP_001349920; NP_001349921;
	NP_001349922; NP_001349923; NP_001349924; NP_001349925; NP_001349926; NP_001349927; NP_001349928
	위키데이터
인간 보기/편집	마우스 표시/편집

플라코필린-4는 인간에서 PKP4 유전자에 ^[5]^[6]^[7]의해 암호화되는 단백질이다.

기능.

아르마딜로 같은 단백질은 드로소필라 '아르마딜로' 유전자 생성물에 처음 정의되는 일련의 아르마딜로 반복에 의해 특징지어지는데, 일반적으로 길이는 42에서 45개의 아미노산입니다.이러한 단백질은 반복의 수, 전체적인 배열 유사성, 그리고 그들의 배열 전체에 걸친 반복의 분산을 기반으로 하위 패밀리로 나눌 수 있다.CTND1, CTND2, PKP1, PKP2, PKP4, ARVCF를 포함한 아르마딜로 유사 단백질의 p120(ctn)/플라코필린 서브패밀리의 구성원.PKP4는 데스모솜 플라크 및 기타 접착 플라크의 구성 요소일 수 있으며 접합 플라크 구성과 카드헤린 기능을 조절하는 데 관여하는 것으로 생각된다.이 유전자에 대해 여러 개의 전사 변형이 발견되었지만, 그 중 두 개의 전장 특성만이 지금까지 기술되었다.이 두 변형은 서로 다른 ^[7]등형식을 부호화합니다.

상호 작용

PKP4는 다음 제품과 상호 작용하는 것으로 나타났습니다.

레퍼런스

^ ^a ^b ^c GRCh38: 앙상블 릴리즈 89: ENSG00000144283 - 앙상블, 2017년 5월
^ ^a ^b ^c GRCm38: 앙상블 릴리즈 89: ENSMUSG000026991 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Paffenholz R, Franke WW (December 1997). "Identification and localization of a neurally expressed member of the plakoglobin/armadillo multigene family". Differentiation. 61 (5): 293–304. doi:10.1046/j.1432-0436.1997.6150293.x. PMID 9342840.
^ Hatzfeld M, Nachtsheim C (May 1997). "Cloning and characterization of a new armadillo family member, p0071, associated with the junctional plaque: evidence for a subfamily of closely related proteins". J Cell Sci. 109 (11): 2767–78. doi:10.1242/jcs.109.11.2767. PMID 8937994.
^ ^a ^b "Entrez Gene: PKP4 plakophilin 4".
^ Izawa I, Nishizawa M, Tomono Y, Ohtakara K, Takahashi T, Inagaki M (May 2002). "ERBIN associates with p0071, an armadillo protein, at cell-cell junctions of epithelial cells". Genes Cells. 7 (5): 475–85. doi:10.1046/j.1365-2443.2002.00533.x. PMID 12047349. S2CID 12598418.
^ Jaulin-Bastard F, Arsanto JP, Le Bivic A, Navarro C, Vély F, Saito H, Marchetto S, Hatzfeld M, Santoni MJ, Birnbaum D, Borg JP (January 2002). "Interaction between Erbin and a Catenin-related protein in epithelial cells". J. Biol. Chem. 277 (4): 2869–75. doi:10.1074/jbc.M109652200. PMID 11711544.
^ Laura RP, Witt AS, Held HA, Gerstner R, Deshayes K, Koehler MF, Kosik KS, Sidhu SS, Lasky LA (April 2002). "The Erbin PDZ domain binds with high affinity and specificity to the carboxyl termini of delta-catenin and ARVCF". J. Biol. Chem. 277 (15): 12906–14. doi:10.1074/jbc.M200818200. PMID 11821434.
^ Deguchi M, Iizuka T, Hata Y, Nishimura W, Hirao K, Yao I, Kawabe H, Takai Y (September 2000). "PAPIN. A novel multiple PSD-95/Dlg-A/ZO-1 protein interacting with neural plakophilin-related armadillo repeat protein/delta-catenin and p0071". J. Biol. Chem. 275 (38): 29875–80. doi:10.1074/jbc.M005384200. PMID 10896674.
^ Ohno H, Hirabayashi S, Iizuka T, Ohnishi H, Fujita T, Hata Y (October 2002). "Localization of p0071-interacting proteins, plakophilin-related armadillo-repeat protein-interacting protein (PAPIN) and ERBIN, in epithelial cells". Oncogene. 21 (46): 7042–9. doi:10.1038/sj.onc.1205852. PMID 12370826.
^ Stahl B, Diehlmann A, Südhof TC (April 1999). "Direct interaction of Alzheimer's disease-related presenilin 1 with armadillo protein p0071". J. Biol. Chem. 274 (14): 9141–8. doi:10.1074/jbc.274.14.9141. PMID 10092585.

추가 정보

Keil R, Wolf A, Hüttelmaier S, Hatzfeld M (2007). "Beyond regulation of cell adhesion: local control of RhoA at the cleavage furrow by the p0071 catenin". Cell Cycle. 6 (2): 122–7. doi:10.4161/cc.6.2.3741. PMID 17264675.
Bonné S, van Hengel J, van Roy F (1998). "Chromosomal mapping of human armadillo genes belonging to the p120(ctn)/plakophilin subfamily". Genomics. 51 (3): 452–4. doi:10.1006/geno.1998.5398. PMID 9721216.
Levesque G, Yu G, Nishimura M, Zhang DM, Levesque L, Yu H, Xu D, Liang Y, Rogaeva E, Ikeda M, Duthie M, Murgolo N, Wang L, VanderVere P, Bayne ML, Strader CD, Rommens JM, Fraser PE, St George-Hyslop P (1999). "Presenilins interact with armadillo proteins including neural-specific plakophilin-related protein and beta-catenin". J. Neurochem. 72 (3): 999–1008. doi:10.1046/j.1471-4159.1999.0720999.x. PMID 10037471. S2CID 36124450.
Stahl B, Diehlmann A, Südhof TC (1999). "Direct interaction of Alzheimer's disease-related presenilin 1 with armadillo protein p0071". J. Biol. Chem. 274 (14): 9141–8. doi:10.1074/jbc.274.14.9141. PMID 10092585.
Deguchi M, Iizuka T, Hata Y, Nishimura W, Hirao K, Yao I, Kawabe H, Takai Y (2000). "PAPIN. A novel multiple PSD-95/Dlg-A/ZO-1 protein interacting with neural plakophilin-related armadillo repeat protein/delta-catenin and p0071". J. Biol. Chem. 275 (38): 29875–80. doi:10.1074/jbc.M005384200. PMID 10896674.
Schröder R, van der Ven PF, Warlo I, Schumann H, Fürst DO, Blümcke I, Schmidt MC, Hatzfeld M (2001). "p0071, a member of the armadillo multigene family, is a constituent of sarcomeric I-bands in human skeletal muscle". J. Muscle Res. Cell. Motil. 21 (6): 577–86. doi:10.1023/A:1026587530656. PMID 11206135. S2CID 1342967.
Jaulin-Bastard F, Arsanto JP, Le Bivic A, Navarro C, Vély F, Saito H, Marchetto S, Hatzfeld M, Santoni MJ, Birnbaum D, Borg JP (2002). "Interaction between Erbin and a Catenin-related protein in epithelial cells". J. Biol. Chem. 277 (4): 2869–75. doi:10.1074/jbc.M109652200. PMID 11711544.
Izawa I, Nishizawa M, Tomono Y, Ohtakara K, Takahashi T, Inagaki M (2002). "ERBIN associates with p0071, an armadillo protein, at cell-cell junctions of epithelial cells". Genes Cells. 7 (5): 475–85. doi:10.1046/j.1365-2443.2002.00533.x. PMID 12047349. S2CID 12598418.
Ohno H, Hirabayashi S, Iizuka T, Ohnishi H, Fujita T, Hata Y (2002). "Localization of p0071-interacting proteins, plakophilin-related armadillo-repeat protein-interacting protein (PAPIN) and ERBIN, in epithelial cells". Oncogene. 21 (46): 7042–9. doi:10.1038/sj.onc.1205852. PMID 12370826.
Calkins CC, Hoepner BL, Law CM, Novak MR, Setzer SV, Hatzfeld M, Kowalczyk AP (2003). "The Armadillo family protein p0071 is a VE-cadherin- and desmoplakin-binding protein". J. Biol. Chem. 278 (3): 1774–83. doi:10.1074/jbc.M205693200. PMID 12426320.
Salomon AR, Ficarro SB, Brill LM, Brinker A, Phung QT, Ericson C, Sauer K, Brock A, Horn DM, Schultz PG, Peters EC (2003). "Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry". Proc. Natl. Acad. Sci. U.S.A. 100 (2): 443–8. Bibcode:2003PNAS..100..443S. doi:10.1073/pnas.2436191100. PMC 141014. PMID 12522270.
Hatzfeld M, Green KJ, Sauter H (2003). "Targeting of p0071 to desmosomes and adherens junctions is mediated by different protein domains". J. Cell Sci. 116 (Pt 7): 1219–33. doi:10.1242/jcs.00275. PMID 12615965.
Setzer SV, Calkins CC, Garner J, Summers S, Green KJ, Kowalczyk AP (2004). "Comparative analysis of armadillo family proteins in the regulation of a431 epithelial cell junction assembly, adhesion and migration". J. Invest. Dermatol. 123 (3): 426–33. doi:10.1111/j.0022-202X.2004.23319.x. PMID 15304078.
Zhang Y, Wolf-Yadlin A, Ross PL, Pappin DJ, Rush J, Lauffenburger DA, White FM (2005). "Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules". Mol. Cell. Proteomics. 4 (9): 1240–50. doi:10.1074/mcp.M500089-MCP200. PMID 15951569.
Tao WA, Wollscheid B, O'Brien R, Eng JK, Li XJ, Bodenmiller B, Watts JD, Hood L, Aebersold R (2005). "Quantitative phosphoproteome analysis using a dendrimer conjugation chemistry and tandem mass spectrometry". Nat. Methods. 2 (8): 591–8. doi:10.1038/nmeth776. PMID 16094384. S2CID 20475874.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.

인간 염색체 2번 유전자에 대한 이 기사는 뭉툭한 것이다.위키피디아를 확장함으로써 위키피디아를 도울 수 있습니다.

[refGRCh38Ensembl-1] GRCh38: 앙상블 릴리즈 89: ENSG00000144283 - 앙상블, 2017년 5월

[refGRCm38Ensembl-2] GRCm38: 앙상블 릴리즈 89: ENSMUSG000026991 - 앙상블, 2017년 5월

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9342840-5] Paffenholz R, Franke WW (December 1997). "Identification and localization of a neurally expressed member of the plakoglobin/armadillo multigene family". Differentiation. 61 (5): 293–304. doi:10.1046/j.1432-0436.1997.6150293.x. PMID 9342840.

[pmid8937994-6] Hatzfeld M, Nachtsheim C (May 1997). "Cloning and characterization of a new armadillo family member, p0071, associated with the junctional plaque: evidence for a subfamily of closely related proteins". J Cell Sci. 109 (11): 2767–78. doi:10.1242/jcs.109.11.2767. PMID 8937994.

[entrez-7] "Entrez Gene: PKP4 plakophilin 4".

[pmid12047349-8] Izawa I, Nishizawa M, Tomono Y, Ohtakara K, Takahashi T, Inagaki M (May 2002). "ERBIN associates with p0071, an armadillo protein, at cell-cell junctions of epithelial cells". Genes Cells. 7 (5): 475–85. doi:10.1046/j.1365-2443.2002.00533.x. PMID 12047349. S2CID 12598418.

[pmid11711544-9] Jaulin-Bastard F, Arsanto JP, Le Bivic A, Navarro C, Vély F, Saito H, Marchetto S, Hatzfeld M, Santoni MJ, Birnbaum D, Borg JP (January 2002). "Interaction between Erbin and a Catenin-related protein in epithelial cells". J. Biol. Chem. 277 (4): 2869–75. doi:10.1074/jbc.M109652200. PMID 11711544.

[pmid11821434-10] Laura RP, Witt AS, Held HA, Gerstner R, Deshayes K, Koehler MF, Kosik KS, Sidhu SS, Lasky LA (April 2002). "The Erbin PDZ domain binds with high affinity and specificity to the carboxyl termini of delta-catenin and ARVCF". J. Biol. Chem. 277 (15): 12906–14. doi:10.1074/jbc.M200818200. PMID 11821434.

[pmid10896674-11] Deguchi M, Iizuka T, Hata Y, Nishimura W, Hirao K, Yao I, Kawabe H, Takai Y (September 2000). "PAPIN. A novel multiple PSD-95/Dlg-A/ZO-1 protein interacting with neural plakophilin-related armadillo repeat protein/delta-catenin and p0071". J. Biol. Chem. 275 (38): 29875–80. doi:10.1074/jbc.M005384200. PMID 10896674.

[pmid12370826-12] Ohno H, Hirabayashi S, Iizuka T, Ohnishi H, Fujita T, Hata Y (October 2002). "Localization of p0071-interacting proteins, plakophilin-related armadillo-repeat protein-interacting protein (PAPIN) and ERBIN, in epithelial cells". Oncogene. 21 (46): 7042–9. doi:10.1038/sj.onc.1205852. PMID 12370826.

[pmid10092585-13] Stahl B, Diehlmann A, Südhof TC (April 1999). "Direct interaction of Alzheimer's disease-related presenilin 1 with armadillo protein p0071". J. Biol. Chem. 274 (14): 9141–8. doi:10.1074/jbc.274.14.9141. PMID 10092585.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

[11]

[12]

[13]

Search

플라코필린-4

네임스페이스

더

목차

기능.

상호 작용

레퍼런스

추가 정보