폴리콤 그룹 RING 핑거 단백질 1, PCGF1은 NSPC1 또는 RNF68로도 알려져 있으며, 사람에게서 PCGF1 [5] [6] RING 핑거 도메인 단백질이다.
PCGF1은 RING1A/B , RYBP , BCOR 및 KDM2B 와 상호작용하는 비표준 폴리콤 억제 복합체 1.1(ncPRC1)을 정의하는 성분이다.PCGF1-BCOR 어셈블리는 PCGF의 유비퀴틴 유사 RAWUL 도메인과 IS1을 통해 모집된다. PCGF1은 PRC1과 유사한 복합체 내에서 히스톤 H2A에 대한 Lys119의 유비퀴티화 를 촉매하는 RING1B 유비퀴틴 리가아제 활성을 조절 하고, 그 후 PRC2 및 H3K27me3를 모집하여 효과적 으로 폴리콤 도메인을 개시하고 유전자 억제를 매개한다. [12] [13] [14]
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