인간의 단백질 코드 유전자
SEC13 단백질 8(mLST8) 또는 TORC 서브유닛 LST8 또는 G 단백질 베타 서브유닛 유사(GβL 또는 Gable)와 함께 치명적인 포유류 라고도 알려진 라파마이신 복합 서브유닛 LST8의 대상 은 MLST8 (MTOR 관련 단백질, LST)에 의해 인체에서 코드되는 단백질 이다.그것은 영양소,[6] mTORC1 과 mTORC2 의 하위 단위이다. 그것은 몇몇 사람의 대장암과 전립선암 세포주 그리고 조직에서 상향 조절된다. mLST8의 녹다운은 mTORC 형성을 방지하고 종양 성장과 [7]
레퍼런스 추가 정보 Ali SM, Sabatini DM (2005). "Structure of S6 kinase 1 determines whether raptor-mTOR or rictor-mTOR phosphorylates its hydrophobic motif site" . J. Biol. Chem . 280 (20): 19445–8. doi :10.1074/jbc.C500125200 PMID 15809305 . Rodgers BD, Levine MA, Bernier M, Montrose-Rafizadeh C (2001). "Insulin regulation of a novel WD-40 repeat protein in adipocytes" . J. Endocrinol . 168 (2): 325–32. doi :10.1677/joe.0.1680325 PMID 11182770 . Long X, Lin Y, Ortiz-Vega S, et al. (2005). "Rheb binds and regulates the mTOR kinase" . Curr. Biol . 15 (8): 702–13. doi :10.1016/j.cub.2005.02.053 PMID 15854902 . S2CID 3078706 . Kaizuka T, Hara T, Oshiro N, et al. (2010). "Tti1 and Tel2 are critical factors in mammalian target of rapamycin complex assembly" . J. Biol. Chem . 285 (26): 20109–16. doi :10.1074/jbc.M110.121699 PMC 2888423 PMID 20427287 . Loewith R, Jacinto E, Wullschleger S, et al. (2002). "Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control" . Mol. Cell . 10 (3): 457–68. doi :10.1016/S1097-2765(02)00636-6 PMID 12408816 . Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes" . Genome Res . 16 (1): 55–65. doi :10.1101/gr.4039406 . PMC 1356129 PMID 16344560 . Sarbassov DD, Sabatini DM (2005). "Redox regulation of the nutrient-sensitive raptor-mTOR pathway and complex" . J. Biol. Chem . 280 (47): 39505–9. doi :10.1074/jbc.M506096200 PMID 16183647 . Oshiro N, Yoshino K, Hidayat S, et al. (2004). "Dissociation of raptor from mTOR is a mechanism of rapamycin-induced inhibition of mTOR function" . Genes Cells . 9 (4): 359–66. doi :10.1111/j.1356-9597.2004.00727.x PMID 15066126 . S2CID 24814691 . Inoki K, Ouyang H, Li Y, Guan KL (2005). "Signaling by target of rapamycin proteins in cell growth control" . Microbiol. Mol. Biol. Rev . 69 (1): 79–100. doi :10.1128/MMBR.69.1.79-100.2005 . PMC 1082789 PMID 15755954 . Behrends C, Sowa ME, Gygi SP, Harper JW (2010). "Network organization of the human autophagy system" . Nature . 466 (7302): 68–76. Bibcode :2010Natur.466...68B . doi :10.1038/nature09204 . PMC 2901998 PMID 20562859 . Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5. doi :10.1038/ng1285 PMID 14702039 . Kawai S, Enzan H, Hayashi Y, et al. (2003). "Vinculin: a novel marker for quiescent and activated hepatic stellate cells in human and rat livers". Virchows Arch . 443 (1): 78–86. doi :10.1007/s00428-003-0804-4 . PMID 12719976 . S2CID 21552704 . Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Kim DH, Sarbassov DD, Ali SM, et al. (2003). "GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR" . Mol. Cell . 11 (4): 895–904. doi :10.1016/S1097-2765(03)00114-X PMID 12718876 . Jacinto E, Loewith R, Schmidt A, et al. (2004). "Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive". Nat. Cell Biol . 6 (11): 1122–8. doi :10.1038/ncb1183 . PMID 15467718 . S2CID 13831153 . Sarbassov DD, Guertin DA, Ali SM, Sabatini DM (2005). "Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex". Science . 307 (5712): 1098–101. Bibcode :2005Sci...307.1098S . doi :10.1126/science.1106148 . PMID 15718470 . S2CID 45837814 .
