임포틴 서브유닛 알파-2 는 인간 에서 KPNA2 유전자에 [5] [6] 단백질 이다.
단백질 의 핵으로의 수입은 적어도 두 단계를 수반하는 과정이다.첫 번째는 핵 포락선에 대한 단백질의 에너지 의존적 인 도킹이고, 두 번째는 핵 기공 복합체를 통한 에너지 의존적인 전위이다.수입 단백질은 일반적으로 짧은 염기성 아미노산 영역 또는 약 10개의 아미노산 간격을 둔 2개의 그러한 영역으로 구성된 핵 국재 배열(NLS)을 필요로 한다. 핵수입의 첫 번째 단계에 관여하는 단백질은 임포틴 서브유닛 알파-2와 같은 카리오페린 의 알파 임포틴 계열의 구성원이다. 여기 효모 상동체, SRP1(사카로미세스 세레비시아 중합효소 I의 특정 온도 민감 돌연변이 의 억제제)이 포함된다.KPNA2 단백질은 DNA 헬리케이스 Q1 및 SV40 T 항원 의 NLS와 상호작용하며 단백질의 운반에 관여할 수 있다.KPNA2는 또한 V(D)J 재조합 에[7]
상호 작용 카리오페린 알파 2는 다음과 상호작용하는 것 으로 나타났다.
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PDB 갤러리
1ejl : 마우스 임포틴α-SV40 Large T 항원 NLS 펩타이드 복합체
1ejy : 마우스 임포틴α-뉴클레오플라스민 NLS펩타이드 복합체
1iq1 : 임포틴-알파(44-54)-임포틴-알파(70-529) 복합체의 결정구조
1ppm : 인간망막아종 단백질 복합체에서 알파-비파르타이트 NLS를 마우스 Import
1pjn : Xenopus laevis 인산단백질 복합체에서 마우스 임포틴 알파-비파르타이트 NLS N1N2
1q1s : 마우스 임포틴 알파인산화 SV40 CN펩타이드 복합체
1q1t : 마우스 임포틴 알파: 비인산화 SV40 CN펩타이드 복합체
1qgk : 임포틴 알파의 IBB 도메인에 결합하는 임포틴 베타 구조
1y2a : 비클래식 PLSCR1-NLS에 결합된 포유동물 수입 구조
