KLK6

KLK6
사용 가능한 구조
PDB	휴먼 유니프로트 검색: PDBe RCSB
PDB ID 코드 목록
	1GVL, 1L2E, 1LO6, 3VFE, 4D8N
식별자
에일리어스	KLK6, Bssp, Klk7, PRSS18, PRSS9, SP59, hK6, 칼리크레인관련펩티드가수분해효소6
외부 ID	OMIM : 602652 MGI : 1343166 HomoloGene : 68279 GenCard : KLK6
유전자 위치(인간)
크르.	19번 염색체(인간)
끝.	50,969,673 bp
유전자 위치(마우스)
크르.	7번 염색체(쥐)
끝.	43,481,454 bp
RNA발현패턴
	상단 표시 위치:
	미주신경의 하부 신경절; ; 하감람핵; ; 중전두회; ; 핀; ; 뇌량; ; 시신경; ; 시상하핵; ; 흑색 실체; ; 상전정핵; ; 복측 피개부;
	상단 표시 위치:
	입술; ; 척수 전각; ; 폰틴핵; ; 소뇌 피질; ; 운동 뉴런; ; 백색 물질; ; 오목수; ; 복부 피부; ; 등살; ; 내부 캡슐;
	추가 참조 표현식 데이터
	추가 참조 표현식 데이터
유전자 존재론
분자 함수	펩티드가수분해효소활성; 단백질 결합; 세린형펩티드가수분해효소활성; 세린형 엔도펩티드가수분해효소활성; 가수분해효소활성;
셀룰러 컴포넌트	세포질; 세포막내소기관; 세포외 영역; 핵소체; 소포체; 미토콘드리아; 핵; 세포외 공간; 분비 과립;
생물학적 과정	뉴런사; 뉴런 투영 발달 조절; 조직 재생; 아밀로이드 전구체 단백질 대사 과정; 단백질 자동 처리; 단백질 분해; 중추 신경계의 발달; G단백질결합수용체신호경로양조절; 상처에 대한 반응; 콜라겐 이화 과정; 세포분화조절; 미엘리네이션; 호르몬 대사 과정;
	출처:아미고 / QuickGO
맞춤법
	5653
	19144
	ENSG00000167755
	ENSMUSG000050063
	Q92876
	없음
	NM_002774; NM_001012964; NM_001012965; NM_001319948; NM_00131949
	NM_001164696; NM_001164697; NM_001164698; NM_011177
	NP_001012982; NP_001012983; NP_001306877; NP_001306878; NP_002765
	없음
	위키데이터
인간 보기/편집	마우스 표시/편집

칼리크레인-6은 KLK6 ^[5]^[6]^[7]^[8]유전자에 의해 인간에게 암호화되는 단백질이다.

기능.

칼리크레인(Kallikreins)은 다양한 생리 기능을 가진 세린 단백질 분해 효소의 하위 그룹이다.늘어나는 증거는 많은 칼리크레인들이 발암에 관여하고 있고 일부는 새로운 암과 다른 질병 바이오마커로 잠재되어 있다는 것을 암시한다.이 유전자는 19번 염색체의 클러스터에 위치한 15개의 칼리크레인 아족 중 하나이다.암호화된 효소는 스테로이드 호르몬에 의해 조절된다.조직 배양에서 이 효소는 아밀로이드 전구체 단백질로부터 아밀로이드 생성 파편을 생성하는 것으로 밝혀져 알츠하이머병에 걸릴 가능성을 시사한다.이 ^[8]유전자에 대해 서로 다른 아이소폼을 코드하는 복수의 대체 스플라이스 전사 변이가 확인되었다.

레퍼런스

^ ^a ^b ^c GRCh38: 앙상블 릴리즈 89: ENSG00000167755 - 앙상블, 2017년 5월
^ ^a ^b ^c GRCm38: 앙상블 릴리즈 89: ENSMUSG000050063 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Yamashiro K, Tsuruoka N, Kodama S, Tsujimoto M, Yamamura Y, Tanaka T, Nakazato H, Yamaguchi N (Jan 1997). "Molecular cloning of a novel trypsin-like serine protease (neurosin) preferentially expressed in brain". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1350 (1): 11–4. doi:10.1016/s0167-4781(96)00187-x. PMID 9003450.
^ Lundwall A, Band V, Blaber M, Clements JA, Courty Y, Diamandis EP, Fritz H, Lilja H, Malm J, Maltais LJ, Olsson AY, Petraki C, Scorilas A, Sotiropoulou G, Stenman UH, Stephan C, Talieri M, Yousef GM (Jun 2006). "A comprehensive nomenclature for serine proteases with homology to tissue kallikreins" (PDF). Biological Chemistry. 387 (6): 637–41. doi:10.1515/BC.2006.082. PMID 16800724. S2CID 436200.
^ Diamandis, Eleftherios P.; Deperthes, David; Lundwall, Åke (Jun 2006). "Proceedings of the 1st International Symposium on Kallikreins, Lausanne, Switzerland, September 1-3 , 2005". Biological Chemistry. 387 (6): 635–824. doi:10.1515/BC.2006.081. PMID 16800723. S2CID 83910246.
^ ^a ^b "Entrez Gene: KLK6 kallikrein-related peptidase 6".

추가 정보

Yousef GM, Kishi T, Diamandis EP (Mar 2003). "Role of kallikrein enzymes in the central nervous system". Clinica Chimica Acta; International Journal of Clinical Chemistry. 329 (1–2): 1–8. doi:10.1016/S0009-8981(03)00004-4. PMID 12589961.
Menendez-Gonzalez M, Castro-Santos P, Suarez A, Calatayud MT, Perez-Pinera P, Martinez M, Ribacoba R, Gutierrez C (May 2008). "Value of measuring plasmatic levels of neurosin in the diagnosis of Alzheimer's disease". Journal of Alzheimer's Disease. 14 (1): 59–67. doi:10.3233/JAD-2008-14106. PMID 18525128.
Menendez-Gonzalez M, Castro-Santos P, Calatayud MT, Perez-Piñera P, Ribacoba R, Martinez-Rivera M, Gutierrez C, Lopez-Muñiz A, Suarez A (2008). "Plasmatic level of neurosin predicts outcome of mild cognitive impairment". International Archives of Medicine. 1 (1): 11. doi:10.1186/1755-7682-1-11. PMC 2475518. PMID 18620574.
Anisowicz A, Sotiropoulou G, Stenman G, Mok SC, Sager R (Sep 1996). "A novel protease homolog differentially expressed in breast and ovarian cancer". Molecular Medicine. 2 (5): 624–36. doi:10.1007/BF03401646. PMC 2230195. PMID 8898378.
Little SP, Dixon EP, Norris F, Buckley W, Becker GW, Johnson M, Dobbins JR, Wyrick T, Miller JR, MacKellar W, Hepburn D, Corvalan J, McClure D, Liu X, Stephenson D, Clemens J, Johnstone EM (Oct 1997). "Zyme, a novel and potentially amyloidogenic enzyme cDNA isolated from Alzheimer's disease brain". The Journal of Biological Chemistry. 272 (40): 25135–42. doi:10.1074/jbc.272.40.25135. PMID 9312124.
Yousef GM, Luo LY, Scherer SW, Sotiropoulou G, Diamandis EP (Dec 1999). "Molecular characterization of zyme/protease M/neurosin (PRSS9), a hormonally regulated kallikrein-like serine protease". Genomics. 62 (2): 251–9. doi:10.1006/geno.1999.6012. PMID 10610719.
Gan L, Lee I, Smith R, Argonza-Barrett R, Lei H, McCuaig J, Moss P, Paeper B, Wang K (Oct 2000). "Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region". Gene. 257 (1): 119–30. doi:10.1016/S0378-1119(00)00382-6. PMID 11054574.
Petraki CD, Karavana VN, Skoufogiannis PT, Little SP, Howarth DJ, Yousef GM, Diamandis EP (Nov 2001). "The spectrum of human kallikrein 6 (zyme/protease M/neurosin) expression in human tissues as assessed by immunohistochemistry". The Journal of Histochemistry and Cytochemistry. 49 (11): 1431–41. doi:10.1177/002215540104901111. PMID 11668196.
Bernett MJ, Blaber SI, Scarisbrick IA, Dhanarajan P, Thompson SM, Blaber M (Jul 2002). "Crystal structure and biochemical characterization of human kallikrein 6 reveals that a trypsin-like kallikrein is expressed in the central nervous system". The Journal of Biological Chemistry. 277 (27): 24562–70. doi:10.1074/jbc.M202392200. PMID 11983703.
Gomis-Rüth FX, Bayés A, Sotiropoulou G, Pampalakis G, Tsetsenis T, Villegas V, Avilés FX, Coll M (Jul 2002). "The structure of human prokallikrein 6 reveals a novel activation mechanism for the kallikrein family". The Journal of Biological Chemistry. 277 (30): 27273–81. doi:10.1074/jbc.M201534200. PMID 12016211.
Scarisbrick IA, Blaber SI, Lucchinetti CF, Genain CP, Blaber M, Rodriguez M (Jun 2002). "Activity of a newly identified serine protease in CNS demyelination". Brain. 125 (Pt 6): 1283–96. doi:10.1093/brain/awf142. PMID 12023317.
Zarghooni M, Soosaipillai A, Grass L, Scorilas A, Mirazimi N, Diamandis EP (May 2002). "Decreased concentration of human kallikrein 6 in brain extracts of Alzheimer's disease patients". Clinical Biochemistry. 35 (3): 225–31. doi:10.1016/S0009-9120(02)00292-8. PMID 12074831.
Hoffman BR, Katsaros D, Scorilas A, Diamandis P, Fracchioli S, Rigault de la Longrais IA, Colgan T, Puopolo M, Giardina G, Massobrio M, Diamandis EP (Sep 2002). "Immunofluorometric quantitation and histochemical localisation of kallikrein 6 protein in ovarian cancer tissue: a new independent unfavourable prognostic biomarker". British Journal of Cancer. 87 (7): 763–71. doi:10.1038/sj.bjc.6600533. PMC 2364256. PMID 12232761.
Mitsui S, Okui A, Uemura H, Mizuno T, Yamada T, Yamamura Y, Yamaguchi N (Nov 2002). "Decreased cerebrospinal fluid levels of neurosin (KLK6), an aging-related protease, as a possible new risk factor for Alzheimer's disease". Annals of the New York Academy of Sciences. 977: 216–23. doi:10.1111/j.1749-6632.2002.tb04818.x. PMID 12480753. S2CID 40568196.
Hutchinson S, Luo LY, Yousef GM, Soosaipillai A, Diamandis EP (May 2003). "Purification of human kallikrein 6 from biological fluids and identification of its complex with alpha(1)-antichymotrypsin". Clinical Chemistry. 49 (5): 746–51. doi:10.1373/49.5.746. PMID 12709365.
Magklara A, Mellati AA, Wasney GA, Little SP, Sotiropoulou G, Becker GW, Diamandis EP (Aug 2003). "Characterization of the enzymatic activity of human kallikrein 6: Autoactivation, substrate specificity, and regulation by inhibitors". Biochemical and Biophysical Research Communications. 307 (4): 948–55. doi:10.1016/S0006-291X(03)01271-3. PMID 12878203.
Iwata A, Maruyama M, Akagi T, Hashikawa T, Kanazawa I, Tsuji S, Nukina N (Oct 2003). "Alpha-synuclein degradation by serine protease neurosin: implication for pathogenesis of synucleinopathies". Human Molecular Genetics. 12 (20): 2625–35. doi:10.1093/hmg/ddg283. PMID 12928483.
Sauter ER, Lininger J, Magklara A, Hewett JE, Diamandis EP (Feb 2004). "Association of kallikrein expression in nipple aspirate fluid with breast cancer risk". International Journal of Cancer. 108 (4): 588–91. doi:10.1002/ijc.11607. PMID 14696124. S2CID 29116787.
Pampalakis G, Kurlender L, Diamandis EP, Sotiropoulou G (Jul 2004). "Cloning and characterization of novel isoforms of the human kallikrein 6 gene". Biochemical and Biophysical Research Communications. 320 (1): 54–61. doi:10.1016/j.bbrc.2004.04.205. PMID 15207701.

외부 링크

펩티드가수분해효소 및 그 억제제에 대한 MEROPS 온라인 데이터베이스: S01.236

[refGRCh38Ensembl-1] GRCh38: 앙상블 릴리즈 89: ENSG00000167755 - 앙상블, 2017년 5월

[refGRCm38Ensembl-2] GRCm38: 앙상블 릴리즈 89: ENSMUSG000050063 - 앙상블, 2017년 5월

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9003450-5] Yamashiro K, Tsuruoka N, Kodama S, Tsujimoto M, Yamamura Y, Tanaka T, Nakazato H, Yamaguchi N (Jan 1997). "Molecular cloning of a novel trypsin-like serine protease (neurosin) preferentially expressed in brain". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1350 (1): 11–4. doi:10.1016/s0167-4781(96)00187-x. PMID 9003450.

[pmid16800724-6] Lundwall A, Band V, Blaber M, Clements JA, Courty Y, Diamandis EP, Fritz H, Lilja H, Malm J, Maltais LJ, Olsson AY, Petraki C, Scorilas A, Sotiropoulou G, Stenman UH, Stephan C, Talieri M, Yousef GM (Jun 2006). "A comprehensive nomenclature for serine proteases with homology to tissue kallikreins" (PDF). Biological Chemistry. 387 (6): 637–41. doi:10.1515/BC.2006.082. PMID 16800724. S2CID 436200.

[pmid16800723-7] Diamandis, Eleftherios P.; Deperthes, David; Lundwall, Åke (Jun 2006). "Proceedings of the 1st International Symposium on Kallikreins, Lausanne, Switzerland, September 1-3 , 2005". Biological Chemistry. 387 (6): 635–824. doi:10.1515/BC.2006.081. PMID 16800723. S2CID 83910246.

[entrez-8] "Entrez Gene: KLK6 kallikrein-related peptidase 6".

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KLK6

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레퍼런스

추가 정보

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