KLK4

KLK4
사용 가능한 구조
PDB	Ortholog 검색: PDBe RCSB
PDB ID 코드 목록
	2BDG, 2BDH, 2BDI, 4K1E, 4K8Y, 4KEL, 4KGA
식별자
에일리어스	KLK4, AI2A1, ARM1, EMSP1, KLK-L1, PRSS17, PSTS, 칼리크레인, 칼리크레인관련펩티드가수분해효소4
외부 ID	OMIM : 603767 MGI : 1861379 HomoloGene : 55856 GenCard : KLK4
유전자 위치(인간)
크르.	19번 염색체(인간)
끝.	50,136,395 bp
유전자 위치(마우스)
크르.	7번 염색체(쥐)
끝.	43,535,228 bp
RNA발현패턴
	상단 표시 위치:
	전립선; ; 복부 피부; ; 침샘; ; 소침샘; ; 갑상선 좌엽; ; 자궁경관; ; 상부 신경; ; 췌장체; ; 갑상선 우엽; ; 간우엽;
	상단 표시 위치:
	어금니; ; 흉선; ; 근육 기관; ; 마름모꼴 뇌; ; 뇌하수체; ; 지방 조직; ; 갈색 지방 조직; ; 근육 조직; ; 몸통; ; 몸통의 복부 부분;
	추가 참조 표현식 데이터
	추가 참조 표현식 데이터
유전자 존재론
분자 함수	펩티드가수분해효소활성; 세린형펩티드가수분해효소활성; 단백질 결합; 가수분해효소활성; 금속 이온 결합; 세린형 엔도펩티드가수분해효소활성;
셀룰러 컴포넌트	세포외 영역; 분비 과립;
생물학적 과정	단백질 분해; 아멜로제네시스; 생체 조직 발달; 세포외기질분해;
	출처:아미고 / QuickGO
맞춤법
	9622
	56640
	ENSG00000167749
	ENSMUSG00000006948
	Q9Y5K2
	Q9Z0M1
	NM_001302961; NM_004917
	NM_019928
	NP_001289890; NP_004908
	NP_064312
	위키데이터
인간 보기/편집	마우스 표시/편집

칼리크레인 관련 펩티드가수분해효소 4는 KLK4 ^[5]^[6]^[7]유전자에 의해 인체 내에서 암호화되는 단백질이다.

칼리크레인(Kallikreins)은 다양한 생리 기능을 ^[8]가진 세린 단백질 분해 효소의 하위 그룹이다.늘어나는 증거는 많은 칼리크레인들이 발암에 관여하고 있고 일부는 새로운 암과 다른 질병 바이오마커로 잠재되어 있다는 것을 암시한다.특히, 그것들은 전립선암과 유방암의 바이오마커 역할을 할 수 있다.

이 유전자는 19번 염색체의 클러스터에 위치한 15개의 칼리크레인 아족 중 하나이다.일부 조직에서는 그 발현이 호르몬에 의해 조절된다.쥐가 자라는 치아에서 유사한 쥐 단백질의 발현 패턴은 에나멜 ^[9]단백질의 분해에서 단백질의 역할을 지지합니다.이 유전자에 대한 대체 스플라이스 변형이 설명되었지만, 생물학적 타당성은 ^[10]결정되지 않았다.

레퍼런스

^ ^a ^b ^c GRCh38: 앙상블 릴리즈 89: ENSG00000167749 - 앙상블, 2017년 5월
^ ^a ^b ^c GRCm38: 앙상블 릴리즈 89: ENSMUSG00000006948 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Simmer JP, Fukae M, Tanabe T, Yamakoshi Y, Uchida T, Xue J, Margolis HC, Shimizu M, DeHart BC, Hu CC, Bartlett JD (February 1998). "Purification, characterization, and cloning of enamel matrix serine proteinase 1". Journal of Dental Research. 77 (2): 377–86. doi:10.1177/00220345980770020601. PMID 9465170. S2CID 21816663. Archived from the original on 2008-08-21. Retrieved 2008-10-20.
^ Nelson PS, Gan L, Ferguson C, Moss P, Gelinas R, Hood L, Wang K (March 1999). "Molecular cloning and characterization of prostase, an androgen-regulated serine protease with prostate-restricted expression". Proceedings of the National Academy of Sciences of the United States of America. 96 (6): 3114–9. Bibcode:1999PNAS...96.3114N. doi:10.1073/pnas.96.6.3114. PMC 15904. PMID 10077646.
^ Stephenson SA, Verity K, Ashworth LK, Clements JA (August 1999). "Localization of a new prostate-specific antigen-related serine protease gene, KLK4, is evidence for an expanded human kallikrein gene family cluster on chromosome 19q13.3-13.4". The Journal of Biological Chemistry. 274 (33): 23210–4. doi:10.1074/jbc.274.33.23210. PMID 10438493.
^ Lundwall A, Band V, Blaber M, Clements JA, Courty Y, Diamandis EP, Fritz H, Lilja H, Malm J, Maltais LJ, Olsson AY, Petraki C, Scorilas A, Sotiropoulou G, Stenman UH, Stephan C, Talieri M, Yousef GM (June 2006). "A comprehensive nomenclature for serine proteases with homology to tissue kallikreins". Biological Chemistry. 387 (6): 637–41. doi:10.1515/BC.2006.082. PMID 16800724. S2CID 436200.
^ Simmer JP, Fukae M, Tanabe T, Yamakoshi Y, Uchida T, Xue J, Margolis HC, Shimizu M, DeHart BC, Hu CC, Bartlett JD (June 2000). "Characterization of the mouse and human PRSS17 genes, their relationship to other serine proteases, and the expression of PRSS17 in developing mouse incisors". Gene. 251 (1): 1–8. doi:10.1016/S0378-1119(00)00203-1. PMID 10863090. Archived from the original on 2008-08-21. Retrieved 2008-10-20.
^ "Entrez Gene: KLK4 kallikrein-related peptidase 4".

추가 정보

Clements J, Hooper J, Dong Y, Harvey T (2001). "The expanded human kallikrein (KLK) gene family: genomic organisation, tissue-specific expression and potential functions" (PDF). Biol. Chem. 382 (1): 5–14. doi:10.1515/BC.2001.002. PMID 11258672. S2CID 5864448.
Simmer JP, Fukae M, Tanabe T, et al. (1998). "Purification, characterization, and cloning of enamel matrix serine proteinase 1". J. Dent. Res. 77 (2): 377–86. doi:10.1177/00220345980770020601. PMID 9465170. S2CID 21816663.
Nelson PS, Gan L, Ferguson C, et al. (1999). "Molecular cloning and characterization of prostase, an androgen-regulated serine protease with prostate-restricted expression". Proc. Natl. Acad. Sci. U.S.A. 96 (6): 3114–9. Bibcode:1999PNAS...96.3114N. doi:10.1073/pnas.96.6.3114. PMC 15904. PMID 10077646.
Stephenson SA, Verity K, Ashworth LK, Clements JA (1999). "Localization of a new prostate-specific antigen-related serine protease gene, KLK4, is evidence for an expanded human kallikrein gene family cluster on chromosome 19q13.3-13.4". J. Biol. Chem. 274 (33): 23210–4. doi:10.1074/jbc.274.33.23210. PMID 10438493.
Yousef GM, Obiezu CV, Luo LY, et al. (1999). "Prostase/KLK-L1 is a new member of the human kallikrein gene family, is expressed in prostate and breast tissues, and is hormonally regulated". Cancer Res. 59 (17): 4252–6. PMID 10485467.
DuPont BR, Hu CC, Reveles X, Simmer JP (2000). "Assignment of serine protease 17 (PRSS17) to human chromosome bands 19q13.3→q13.4 by in situ hybridization". Cytogenet. Cell Genet. 86 (3–4): 212–3. doi:10.1159/000015340. PMID 10575207. S2CID 42446073.
Hu JC, Zhang C, Sun X, et al. (2000). "Characterization of the mouse and human PRSS17 genes, their relationship to other serine proteases, and the expression of PRSS17 in developing mouse incisors". Gene. 251 (1): 1–8. doi:10.1016/S0378-1119(00)00203-1. PMID 10863090.
Gan L, Lee I, Smith R, et al. (2001). "Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region". Gene. 257 (1): 119–30. doi:10.1016/S0378-1119(00)00382-6. PMID 11054574.
Obiezu CV, Diamandis EP (2001). "An alternatively spliced variant of KLK4 expressed in prostatic tissue". Clin. Biochem. 33 (7): 599–600. doi:10.1016/S0009-9120(00)00178-8. PMID 11124349.
Takayama TK, Carter CA, Deng T (2001). "Activation of prostate-specific antigen precursor (pro-PSA) by prostin, a novel human prostatic serine protease identified by degenerate PCR". Biochemistry. 40 (6): 1679–87. doi:10.1021/bi002129r. PMID 11327827.
Korkmaz KS, Korkmaz CG, Pretlow TG, Saatcioglu F (2001). "Distinctly different gene structure of KLK4/KLK-L1/prostase/ARM1 compared with other members of the kallikrein family: intracellular localization, alternative cDNA forms, and Regulation by multiple hormones". DNA Cell Biol. 20 (7): 435–45. doi:10.1089/104454901750361497. PMID 11506707.
Takayama TK, McMullen BA, Nelson PS, et al. (2002). "Characterization of hK4 (prostase), a prostate-specific serine protease: activation of the precursor of prostate specific antigen (pro-PSA) and single-chain urokinase-type plasminogen activator and degradation of prostatic acid phosphatase". Biochemistry. 40 (50): 15341–8. doi:10.1021/bi015775e. PMID 11735417.
Hural JA, Friedman RS, McNabb A, et al. (2002). "Identification of naturally processed CD4 T cell epitopes from the prostate-specific antigen kallikrein 4 using peptide-based in vitro stimulation". J. Immunol. 169 (1): 557–65. doi:10.4049/jimmunol.169.1.557. PMID 12077288.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19". Nature. 428 (6982): 529–35. Bibcode:2004Natur.428..529G. doi:10.1038/nature02399. PMID 15057824.
Xi Z, Klokk TI, Korkmaz K, et al. (2004). "Kallikrein 4 is a predominantly nuclear protein and is overexpressed in prostate cancer". Cancer Res. 64 (7): 2365–70. doi:10.1158/0008-5472.CAN-03-2025. PMID 15059887.
Hart PS, Hart TC, Michalec MD, et al. (2004). "Mutation in kallikrein 4 causes autosomal recessive hypomaturation amelogenesis imperfecta". J. Med. Genet. 41 (7): 545–9. doi:10.1136/jmg.2003.017657. PMC 1735847. PMID 15235027.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Veveris-Lowe TL, Lawrence MG, Collard RL, et al. (2005). "Kallikrein 4 (hK4) and prostate-specific antigen (PSA) are associated with the loss of E-cadherin and an epithelial-mesenchymal transition (EMT)-like effect in prostate cancer cells". Endocr. Relat. Cancer. 12 (3): 631–43. doi:10.1677/erc.1.00958. PMID 16172196.

외부 링크

펩티드가수분해효소 및 그 억제제에 대한 MEROPS 온라인 데이터베이스: S01.251

[refGRCh38Ensembl-1] GRCh38: 앙상블 릴리즈 89: ENSG00000167749 - 앙상블, 2017년 5월

[refGRCm38Ensembl-2] GRCm38: 앙상블 릴리즈 89: ENSMUSG00000006948 - 앙상블, 2017년 5월

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9465170-5] Simmer JP, Fukae M, Tanabe T, Yamakoshi Y, Uchida T, Xue J, Margolis HC, Shimizu M, DeHart BC, Hu CC, Bartlett JD (February 1998). "Purification, characterization, and cloning of enamel matrix serine proteinase 1". Journal of Dental Research. 77 (2): 377–86. doi:10.1177/00220345980770020601. PMID 9465170. S2CID 21816663. Archived from the original on 2008-08-21. Retrieved 2008-10-20.

[pmid10077646-6] Nelson PS, Gan L, Ferguson C, Moss P, Gelinas R, Hood L, Wang K (March 1999). "Molecular cloning and characterization of prostase, an androgen-regulated serine protease with prostate-restricted expression". Proceedings of the National Academy of Sciences of the United States of America. 96 (6): 3114–9. Bibcode:1999PNAS...96.3114N. doi:10.1073/pnas.96.6.3114. PMC 15904. PMID 10077646.

[pmid10438493-7] Stephenson SA, Verity K, Ashworth LK, Clements JA (August 1999). "Localization of a new prostate-specific antigen-related serine protease gene, KLK4, is evidence for an expanded human kallikrein gene family cluster on chromosome 19q13.3-13.4". The Journal of Biological Chemistry. 274 (33): 23210–4. doi:10.1074/jbc.274.33.23210. PMID 10438493.

[pmid16800724-8] Lundwall A, Band V, Blaber M, Clements JA, Courty Y, Diamandis EP, Fritz H, Lilja H, Malm J, Maltais LJ, Olsson AY, Petraki C, Scorilas A, Sotiropoulou G, Stenman UH, Stephan C, Talieri M, Yousef GM (June 2006). "A comprehensive nomenclature for serine proteases with homology to tissue kallikreins". Biological Chemistry. 387 (6): 637–41. doi:10.1515/BC.2006.082. PMID 16800724. S2CID 436200.

[pmid10863090-9] Simmer JP, Fukae M, Tanabe T, Yamakoshi Y, Uchida T, Xue J, Margolis HC, Shimizu M, DeHart BC, Hu CC, Bartlett JD (June 2000). "Characterization of the mouse and human PRSS17 genes, their relationship to other serine proteases, and the expression of PRSS17 in developing mouse incisors". Gene. 251 (1): 1–8. doi:10.1016/S0378-1119(00)00203-1. PMID 10863090. Archived from the original on 2008-08-21. Retrieved 2008-10-20.

[entrez-10] "Entrez Gene: KLK4 kallikrein-related peptidase 4".

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KLK4

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