호모 사피엔스 종의 유전자
Kallikrein-13 은 KLK13 유전자에 [4] [5] [6] 단백질 이다.
칼리크레인(Kallikreins)은 다양한 생리 기능을 가진 세린 단백질 분해 효소의 하위 그룹이다. 늘어나는 증거는 많은 칼리크레인들이 발암에 관여하고 있고 일부는 새로운 암과 다른 질병 바이오마커로 잠재되어 있다는 것을 암시한다. 이 유전자는 19번 염색체의 클러스터에 위치한 15개의 칼리크레인 아족 중 하나이다. 이 유전자의 발현은 스테로이드 호르몬에 의해 조절되며 유방암의 지표로서 유용할 수 있다. 추가 트랜스크립트 변형은 식별되었지만 전체 길이 시퀀스는 [6]
레퍼런스 ^ a b c GRCm38: 앙상블 릴리즈 89: ENSMUSG000054046 - 앙상블 , 2017년 5월^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Lundwall A, Band V, Blaber M, Clements JA, Courty Y, Diamandis EP, Fritz H, Lilja H, Malm J, Maltais LJ, Olsson AY, Petraki C, Scorilas A, Sotiropoulou G, Stenman UH, Stephan C, Talieri M, Yousef GM (Jun 2006). "A comprehensive nomenclature for serine proteases with homology to tissue kallikreins" (PDF) . Biol Chem . 387 (6): 637–41. doi :10.1515/BC.2006.082 . PMID 16800724 . S2CID 436200 . ^ Diamandis, Eleftherios P.; Deperthes, David; Lundwall, Åke (Jun 2006). "Proceedings of the 1st International Symposium on Kallikreins, Lausanne, Switzerland, September 1-3 , 2005". Biol Chem . 387 (6): 635–824. doi :10.1515/BC.2006.081 . PMID 16800723 . S2CID 83910246 . ^ a b "Entrez Gene: KLK13 kallikrein-related peptidase 13" . 추가 정보 Diamandis EP, Yousef GM, Luo LY, et al. (2001). "The new human kallikrein gene family: implications in carcinogenesis". Trends Endocrinol. Metab . 11 (2): 54–60. doi :10.1016/S1043-2760(99)00225-8 . PMID 10675891 . S2CID 25806934 . Yousef GM, Chang A, Diamandis EP (2000). "Identification and characterization of KLK-L4, a new kallikrein-like gene that appears to be down-regulated in breast cancer tissues" . J. Biol. Chem . 275 (16): 11891–8. doi :10.1074/jbc.275.16.11891 PMID 10766816 . Yousef GM, Chang A, Scorilas A, Diamandis EP (2000). "Genomic organization of the human kallikrein gene family on chromosome 19q13.3-q13.4". Biochem. Biophys. Res. Commun . 276 (1): 125–33. doi :10.1006/bbrc.2000.3448 . PMID 11006094 . Gan L, Lee I, Smith R, et al. (2001). "Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region". Gene . 257 (1): 119–30. doi :10.1016/S0378-1119(00)00382-6 . PMID 11054574 . Chang A, Yousef GM, Jung K, et al. (2002). "Identification and molecular characterization of five novel kallikrein gene 13 (KLK13; KLK-L4) splice variants: differential expression in the human testis and testicular cancer". Anticancer Res . 21 (5): 3147–52. PMID 11848466 . Chang A, Yousef GM, Scorilas A, et al. (2002). "Human kallikrein gene 13 (KLK13) expression by quantitative RT-PCR: an independent indicator of favourable prognosis in breast cancer" . Br. J. Cancer . 86 (9): 1457–64. doi :10.1038/sj.bjc.6600283 . PMC 2375362 PMID 11986781 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Petraki CD, Karavana VN, Diamandis EP (2003). "Human kallikrein 13 expression in normal tissues: an immunohistochemical study" . J. Histochem. Cytochem . 51 (4): 493–501. doi :10.1177/002215540305100411 PMID 12642628 . Komatsu N, Takata M, Otsuki N, et al. (2003). "Expression and localization of tissue kallikrein mRNAs in human epidermis and appendages" . J. Invest. Dermatol . 121 (3): 542–9. doi :10.1046/j.1523-1747.2003.12363.x PMID 12925213 . Petraki CD, Gregorakis AK, Papanastasiou PA, et al. (2004). "Immunohistochemical localization of human kallikreins 6, 10 and 13 in benign and malignant prostatic tissues" . Prostate Cancer Prostatic Dis . 6 (3): 223–7. doi :10.1038/sj.pcan.4500674 PMID 12970725 . Kapadia C, Yousef GM, Mellati AA, et al. (2004). "Complex formation between human kallikrein 13 and serum protease inhibitors". Clin. Chim. Acta . 339 (1–2): 157–67. doi :10.1016/j.cccn.2003.10.009 . PMID 14687906 . Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19" . Nature . 428 (6982): 529–35. Bibcode :2004Natur.428..529G . doi :10.1038/nature02399 PMID 15057824 . Kapadia C, Ghosh MC, Grass L, Diamandis EP (2004). "Human kallikrein 13 involvement in extracellular matrix degradation". Biochem. Biophys. Res. Commun . 323 (3): 1084–90. doi :10.1016/j.bbrc.2004.08.206 . PMID 15381110 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Darling MR, Jackson-Boeters L, Daley TD, Diamandis EP (2006). "Human kallikrein 13 expression in salivary gland tumors". Int. J. Biol. Markers . 21 (2): 106–10. doi :10.1177/172460080602100206 . PMID 16847813 . S2CID 7038149 .
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