KLK11

KLK11
식별자
에일리어스	KLK11, PRSS20, TLSP, 칼리크레인관련펩티드가수분해효소11
외부 ID	OMIM: 604434 MGI: 1929977 HomoloGene: 27048 GeneCard: KLK11
유전자 위치(인간)
크르.	19번 염색체(인간)
끝.	51,028,039 bp
유전자 위치(마우스)
크르.	7번 염색체(쥐)
끝.	43,428,687 bp
RNA발현패턴
	상단 표시 위치:
	복부 피부; ; 인간의 음경; ; 구강; ; 외음부; ; 자궁경부상피; ; 담낭; ; 소침샘; ; 생식 상피; ; 기관지 상피 세포; ; 니플;
	상단 표시 위치:
	입술; ; 식도; ; 등살; ; 배꼽; ; 복부 피부; ; 기관; ; 배; ; 각막; ; 자궁경부; ; 표피;
	추가 참조 표현식 데이터
	추가 참조 표현식 데이터
유전자 존재론
분자 함수	펩티드가수분해효소활성; 세린형펩티드가수분해효소활성; 가수분해효소활성; 세린형 엔도펩티드가수분해효소활성;
셀룰러 컴포넌트	세포외 영역; 골지 장치; 세포외 엑소좀; 세포외 공간; 분비 과립;
생물학적 과정	단백질 분해;
	출처:아미고 / QuickGO
맞춤법
	11012
	56538
	ENSG00000167757
	ENSMUSG000067616
	Q9UBX7
	Q9QYN3
	NM_001136032; NM_001167605; NM_006853; NM_144947
	NM_001177373; NM_01974
	NP_001129504; NP_001161077; NP_006844; NP_659196
	NP_001170844; NP_064358
	위키데이터
인간 보기/편집	마우스 표시/편집

Kallikrein-11은 KLK11 유전자에 ^[5]^[6]^[7]^[8]^[9]의해 인간에게 암호화되는 단백질이다.

칼리크레인(Kallikreins)은 다양한 생리 기능을 가진 세린 단백질 분해 효소의 하위 그룹이다.늘어나는 증거는 많은 칼리크레인들이 발암에 관여하고 있고 일부는 새로운 암과 다른 질병 바이오마커로 잠재되어 있다는 것을 암시한다.이 유전자는 19번 염색체의 클러스터에 위치한 15개의 칼리크레인 아족 중 하나이다.이 유전자의 대체 스플라이싱은 2개의 전사 변이체가 서로 ^[9]다르게 발현되는 2개의 다른 아이소폼을 코드하는 결과를 낳는다.

레퍼런스

^ ^a ^b ^c GRCh38: 앙상블 릴리즈 89: ENSG00000167757 - 앙상블, 2017년 5월
^ ^a ^b ^c GRCm38: 앙상블 릴리즈 89: ENSMUSG000067616 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Yoshida S, Taniguchi M, Suemoto T, Oka T, He X, Shiosaka S (Oct 1998). "cDNA cloning and expression of a novel serine protease, TLSP". Biochim Biophys Acta. 1399 (2–3): 225–8. doi:10.1016/s0167-4781(98)00116-x. PMID 9765601.
^ Yousef GM, Scorilas A, Diamandis EP (Apr 2000). "Genomic organization, mapping, tissue expression, and hormonal regulation of trypsin-like serine protease (TLSP PRSS20), a new member of the human kallikrein gene family". Genomics. 63 (1): 88–96. doi:10.1006/geno.1999.6072. PMID 10662548.
^ Lundwall A, Band V, Blaber M, Clements JA, Courty Y, Diamandis EP, Fritz H, Lilja H, Malm J, Maltais LJ, Olsson AY, Petraki C, Scorilas A, Sotiropoulou G, Stenman UH, Stephan C, Talieri M, Yousef GM (Jun 2006). "A comprehensive nomenclature for serine proteases with homology to tissue kallikreins" (PDF). Biol Chem. 387 (6): 637–41. doi:10.1515/BC.2006.082. PMID 16800724. S2CID 436200.
^ Diamandis, Eleftherios P.; Deperthes, David; Lundwall, Åke (Jun 2006). "Proceedings of the 1st International Symposium on Kallikreins, Lausanne, Switzerland, September 1-3 , 2005". Biol Chem. 387 (6): 635–824. doi:10.1515/BC.2006.081. PMID 16800723. S2CID 83910246.
^ ^a ^b "Entrez Gene: KLK11 kallikrein-related peptidase 11".

추가 정보

Mitsui S, Yamada T, Okui A, et al. (2000). "A novel isoform of a kallikrein-like protease, TLSP/hippostasin, (PRSS20), is expressed in the human brain and prostate". Biochem. Biophys. Res. Commun. 272 (1): 205–11. doi:10.1006/bbrc.2000.2761. PMID 10872828.
Gan L, Lee I, Smith R, et al. (2001). "Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region". Gene. 257 (1): 119–30. doi:10.1016/S0378-1119(00)00382-6. PMID 11054574.
Nakamura T, Mitsui S, Okui A, et al. (2002). "Alternative splicing isoforms of hippostasin (PRSS20/KLK11) in prostate cancer cell lines". Prostate. 49 (1): 72–8. doi:10.1002/pros.1119. PMID 11550212. S2CID 21572408.
Diamandis EP, Okui A, Mitsui S, et al. (2002). "Human kallikrein 11: a new biomarker of prostate and ovarian carcinoma". Cancer Res. 62 (1): 295–300. PMID 11782391.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Nakamura T, Mitsui S, Okui A, et al. (2003). "Molecular cloning and expression of a variant form of hippostasin/KLK11 in prostate". Prostate. 54 (4): 299–305. doi:10.1002/pros.10191. PMID 12539228. S2CID 21482369.
Nakamura T, Stephan C, Scorilas A, et al. (2003). "Quantitative analysis of hippostasin/KLK11 gene expression in cancerous and noncancerous prostatic tissues". Urology. 61 (5): 1042–6. doi:10.1016/S0090-4295(02)02443-3. PMID 12736044.
Borgoño CA, Fracchioli S, Yousef GM, et al. (2003). "Favorable prognostic value of tissue human kallikrein 11 (hK11) in patients with ovarian carcinoma". Int. J. Cancer. 106 (4): 605–10. CiteSeerX 10.1.1.623.9575. doi:10.1002/ijc.11296. PMID 12845660. S2CID 13671141.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19". Nature. 428 (6982): 529–35. Bibcode:2004Natur.428..529G. doi:10.1038/nature02399. PMID 15057824.
Shigemasa K, Gu L, Tanimoto H, et al. (2004). "Human kallikrein gene 11 (KLK11) mRNA overexpression is associated with poor prognosis in patients with epithelial ovarian cancer". Clin. Cancer Res. 10 (8): 2766–70. doi:10.1158/1078-0432.CCR-03-0269. PMID 15102682.
Diamandis EP, Borgoño CA, Scorilas A, et al. (2005). "Human kallikrein 11: an indicator of favorable prognosis in ovarian cancer patients". Clin. Biochem. 37 (9): 823–9. doi:10.1016/j.clinbiochem.2004.04.009. PMID 15329323.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Stavropoulou P, Gregorakis AK, Plebani M, Scorilas A (2005). "Expression analysis and prognostic significance of human kallikrein 11 in prostate cancer". Clin. Chim. Acta. 357 (2): 190–5. doi:10.1016/j.cccn.2005.03.026. PMID 15893744.
Planque C, Aïnciburu M, Heuzé-Vourc'h N, et al. (2006). "Expression of the human kallikrein genes 10 (KLK10) and 11 (KLK11) in cancerous and non-cancerous lung tissues". Biol. Chem. 387 (6): 783–8. doi:10.1515/BC.2006.098. PMID 16800740. S2CID 6937753.
Mitsui S, Nakamura T, Okui A, et al. (2006). "Multiple promoters regulate tissue-specific alternative splicing of the human kallikrein gene, KLK11/hippostasin". FEBS J. 273 (16): 3678–86. doi:10.1111/j.1742-4658.2006.05372.x. PMID 16911518. S2CID 25021929.

외부 링크

펩티드가수분해효소 및 그 억제제에 대한 MEROPS 온라인 데이터베이스: S01.257

인간 염색체 19번 유전자에 대한 이 기사는 짧은 글이다.위키피디아를 확장함으로써 위키피디아를 도울 수 있습니다.

[refGRCh38Ensembl-1] GRCh38: 앙상블 릴리즈 89: ENSG00000167757 - 앙상블, 2017년 5월

[refGRCm38Ensembl-2] GRCm38: 앙상블 릴리즈 89: ENSMUSG000067616 - 앙상블, 2017년 5월

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9765601-5] Yoshida S, Taniguchi M, Suemoto T, Oka T, He X, Shiosaka S (Oct 1998). "cDNA cloning and expression of a novel serine protease, TLSP". Biochim Biophys Acta. 1399 (2–3): 225–8. doi:10.1016/s0167-4781(98)00116-x. PMID 9765601.

[pmid10662548-6] Yousef GM, Scorilas A, Diamandis EP (Apr 2000). "Genomic organization, mapping, tissue expression, and hormonal regulation of trypsin-like serine protease (TLSP PRSS20), a new member of the human kallikrein gene family". Genomics. 63 (1): 88–96. doi:10.1006/geno.1999.6072. PMID 10662548.

[pmid16800724-7] Lundwall A, Band V, Blaber M, Clements JA, Courty Y, Diamandis EP, Fritz H, Lilja H, Malm J, Maltais LJ, Olsson AY, Petraki C, Scorilas A, Sotiropoulou G, Stenman UH, Stephan C, Talieri M, Yousef GM (Jun 2006). "A comprehensive nomenclature for serine proteases with homology to tissue kallikreins" (PDF). Biol Chem. 387 (6): 637–41. doi:10.1515/BC.2006.082. PMID 16800724. S2CID 436200.

[pmid16800723-8] Diamandis, Eleftherios P.; Deperthes, David; Lundwall, Åke (Jun 2006). "Proceedings of the 1st International Symposium on Kallikreins, Lausanne, Switzerland, September 1-3 , 2005". Biol Chem. 387 (6): 635–824. doi:10.1515/BC.2006.081. PMID 16800723. S2CID 83910246.

[entrez-9] "Entrez Gene: KLK11 kallikrein-related peptidase 11".

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KLK11

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