Jagged-2 는 인간에게 JAG2 유전자 에 의해 암호화된 단백질 이다.[5] [6] [7]
함수 노치 신호경로 는 적절한 배아발달을 위해 필수적인 세포간 신호 메커니즘이다.노치 유전자 계열의 구성원들은 다양한 세포 운명 결정에 중요한 트랜섬브레인 수용체를 암호화한다. 이 유전자에 의해 암호화된 단백질은 노치 및 관련 수용체를 활성화하는 여러 리간드 중 하나이다. 다른 ISO 양식을 인코딩하는 두 개의 대본 변형이 이 유전자에 대해 발견되었다.[7]
상호작용 JAG2는 NOGH2 와 상호작용 하는 것으로 나타났다.[8]
MicroRNA miR-1280은 JAG2 식을 억제하는 것으로 나타났다.[9]
참조 ^ a b c GRCh38: 앙상블 릴리스 89: ENSG00000184916 - 앙상블 , 2017년 5월^ a b c GRCm38: 앙상블 릴리스 89: ENSMUSG00000002799 - 앙상블 , 2017년 5월^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Luo B, Aster JC, Hasserjian RP, Kuo F, Sklar J (October 1997). "Isolation and functional analysis of a cDNA for human Jagged2, a gene encoding a ligand for the Notch1 receptor" . Mol Cell Biol . 17 (10): 6057–67. PMC 232455 PMID 9315665 . ^ Deng Y, Madan A, Banta AB, Friedman C, Trask BJ, Hood L, Li L (April 2000). "Characterization, chromosomal localization, and the complete 30-kb DNA sequence of the human Jagged2 (JAG2) gene". Genomics . 63 (1): 133–8. doi :10.1006/geno.1999.6045 . PMID 10662552 . ^ a b "Entrez Gene: JAG2 jagged 2" .^ Shimizu K, Chiba S, Hosoya N, Kumano K, Saito T, Kurokawa M, Kanda Y, Hamada Y, Hirai H (2000). 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"Mouse Jagged2 is differentially expressed in hematopoietic progenitors and endothelial cells and promotes the survival and proliferation of hematopoietic progenitors by direct cell-to-cell contact". Blood . 96 (3): 950–7. PMID 10910909 . Shimizu K, Chiba S, Hosoya N, Kumano K, Saito T, Kurokawa M, Kanda Y, Hamada Y, Hirai H (2000). "Binding of Delta1, Jagged1, and Jagged2 to Notch2 Rapidly Induces Cleavage, Nuclear Translocation, and Hyperphosphorylation of Notch2" . Mol. Cell. Biol . 20 (18): 6913–22. doi :10.1128/MCB.20.18.6913-6922.2000 . PMC 88767 PMID 10958687 . Shimizu K, Chiba S, Saito T, Kumano K, Hirai H (2000). "Physical interaction of Delta1, Jagged1, and Jagged2 with Notch1 and Notch3 receptors". Biochem. Biophys. Res. Commun . 276 (1): 385–9. doi :10.1006/bbrc.2000.3469 . PMID 11006133 . Cereseto A, Tsai S (2000). "Jagged2 induces cell cycling in confluent fibroblasts susceptible to density-dependent inhibition of cell division". J. Cell. 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