힌트1

힌트1
사용 가능한 구조물
PDB	직교 검색: PDBe RCSB
PDB ID 코드 목록
	1AV5, 1KPA, 1KPB, 1KPC, 1KPE, 1KPF, 3TW2, 4EQE, 4EQG, 4EQH, 4ZKL, 4ZKV, 5I2E, 5I2F
식별자
별칭	힌트1, 힌트, NMAN, PKCI-1, PRKHNH1, 히스티딘 3개 뉴클레오티드 결합 단백질 1
외부 ID	OMIM: 601314 MGI: 1321133 호몰로진: 3904 GeneCard: 힌트1
유전자 위치(인간)
CHR	5번 염색체(인간)
끝	131,224,468bp
유전자 위치(마우스)
CHR	11번 염색체(쥐)
끝	54,761,327bp
RNA 표현 패턴
	표현된 상단
	중간 측두회; ; 브로드만 23구역; ; 자궁내막; ; 결장의; ; 물질적 해부학적 실체;
	추가 참조 표현식 데이터
	; ; ; ;
	추가 참조 표현식 데이터
유전자 온톨로지
분자함수	뉴클레오티드 결합; 촉매 활성; 수산화효소 활동; 단백질 키나아제 C 결합;
셀룰러 컴포넌트	히스톤 디아세틸라제 복합체; 플라즈마 막; 세포외 외성체; 시토스켈레톤; 핵의; 세포질; 시토솔;
생물학적 과정	푸린 리보뉴클레오티드 카타볼릭 공정; 칼슘 매개 신호의 양성 조절; 전사 규정, DNA-템플링; 전사, DNA-템플릿; p53 클래스 중재자에 의한 내적 세포 신호 경로; 신호 전달; 사멸적 과정;
	출처:아미고 / 퀵고
직교체
	3094
	15254
	ENSG00000169567
	ENSMUSG00000020267
	P49773
	P70349
	NM_005340
	NM_008248
	NP_005331
	NP_032274
	위키다타
인간 보기/편집	마우스 보기/편집

히스티딘 트라이아드 뉴클레오티드 결합 단백질 1은 아데노신 5'-모노포스포라미다아제라고도 알려진 효소로, 인간에게 있어 WINT1 유전자에 의해 암호화된 효소다.^[5]^[6]

힌트1은 단일 인산염 그룹으로 푸린 뉴클레오티드 인광산염을 가수 분해한다.^[7]또한 전사 활성화를 변조하는 비계단백질으로서의 기능도 한다.^[8]

대장암 세포의 Wnt/β-catenin 경로와 인간 마스트 세포의 MITF(Michalmia-관련 전사 계수) 활동을 억제하는 하플로이너충족종양 억제 유전자다.^[9]^[10]LysRS-Ap4A-MITF 신호 경로에서, 힌트1은 직접 연관성에 의한 MITF 전사 활동을 금지한다.경로 활성화 시, LysRS에서 생산한 디아데노신 테트라인산염(Ap4A)에 의해 MITF에서 힌트1이 방출된다.^[10]^[11]

참고 항목

히스티딘 3종 뉴클레오티드 결합 단백질 2(HINT2)

참조

^ ^a ^b ^c GRCh38: 앙상블 릴리스 89: ENSG00000169567 - 앙상블, 2017년 5월
^ ^a ^b ^c GRCm38: 앙상블 릴리스 89: ENSMUSG000020267 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Brzoska PM, Chen H, Levin NA, Kuo WL, Collins C, Fu KK, Gray JW, Christman MF (Feb 1997). "Cloning, mapping, and in vivo localization of a human member of the PKCI-1 protein family (PRKCNH1)". Genomics. 36 (1): 151–6. doi:10.1006/geno.1996.0435. PMID 8812426.
^ "Entrez Gene: HINT1 histidine triad nucleotide binding protein 1".
^ Strom A, Tong CL, Wagner CR (May 2020). "Histidine triad nucleotide-binding proteins HINT1 and HINT2 share similar substrate specificities and little affinity for the signaling dinucleotide Ap4A". FEBS Letters. 594 (10): 1497–1505. doi:10.1002/1873-3468.13745. PMID 31990367. S2CID 210933742.
^ "P49773: HINT1 (human)". UniProt.
^ Wang L, Li H, Zhang Y, Santella RM, Weinstein IB (Apr 2009). "HINT1 inhibits beta-catenin/TCF4, USF2 and NFkappaB activity in human hepatoma cells". Int J Cancer. 124 (7): 1526–34. doi:10.1002/ijc.24072. PMC 2667231. PMID 19089909.
^ ^a ^b Lee YN, Nechushtan H, Figov N, Razin E (Feb 2004). "The function of lysyl-tRNA synthetase and Ap4A as signaling regulators of MITF activity in FcepsilonRI-activated mast cells". Immunity. 20 (2): 145–51. doi:10.1016/S1074-7613(04)00020-2. PMID 14975237.
^ Yannay-Cohen N, Carmi-Levy I, Kay G, Yang CM, Han JM, Kemeny DM, Kim S, Nechushtan H, Razin E (June 2009). "LysRS serves as a key signaling molecule in the immune response by regulating gene expression". Mol Cell. 34 (5): 603–11. doi:10.1016/j.molcel.2009.05.019. PMID 19524539.

추가 읽기

Brzoska PM, Chen H, Zhu Y, et al. (1995). "The product of the ataxia-telangiectasia group D complementing gene, ATDC, interacts with a protein kinase C substrate and inhibitor". Proc. Natl. Acad. Sci. U.S.A. 92 (17): 7824–8. doi:10.1073/pnas.92.17.7824. PMC 41238. PMID 7644499.
Lima CD, Klein MG, Weinstein IB, Hendrickson WA (1996). "Three-dimensional structure of human protein kinase C interacting protein 1, a member of the HIT family of proteins". Proc. Natl. Acad. Sci. U.S.A. 93 (11): 5357–62. doi:10.1073/pnas.93.11.5357. PMC 39250. PMID 8643579.
Lima CD, Klein MG, Hendrickson WA (1997). "Structure-based analysis of catalysis and substrate definition in the HIT protein family". Science. 278 (5336): 286–90. doi:10.1126/science.278.5336.286. PMID 9323207.
Klein MG, Yao Y, Slosberg ED, et al. (1998). "Characterization of PKCI and comparative studies with FHIT, related members of the HIT protein family". Exp. Cell Res. 244 (1): 26–32. doi:10.1006/excr.1998.4153. PMID 9770345.
Weitzdoerfer R, Stolzlechner D, Dierssen M, et al. (2002). "Reduction of nucleoside diphosphate kinase B, Rab GDP-dissociation inhibitor beta and histidine triad nucleotide-binding protein in fetal Down syndrome brain". J. Neural Transm. Suppl. (61): 347–59. doi:10.1007/978-3-7091-6262-0_29. ISBN 978-3-211-83704-7. PMID 11771757.
Bieganowski P, Garrison PN, Hodawadekar SC, et al. (2002). "Adenosine monophosphoramidase activity of Hint and Hnt1 supports function of Kin28, Ccl1, and Tfb3". J. Biol. Chem. 277 (13): 10852–60. doi:10.1074/jbc.M111480200. PMC 2556056. PMID 11805111.
Brenner C (2002). "Hint, Fhit, and GalT: function, structure, evolution, and mechanism of three branches of the histidine triad superfamily of nucleotide hydrolases and transferases". Biochemistry. 41 (29): 9003–14. doi:10.1021/bi025942q. PMC 2571077. PMID 12119013.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801. S2CID 23783563.
Galey D, Becker K, Haughey N, et al. (2003). "Differential transcriptional regulation by human immunodeficiency virus type 1 and gp120 in human astrocytes". J. Neurovirol. 9 (3): 358–71. doi:10.1080/13550280390201119. PMID 12775419. S2CID 22016092.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Weiske J, Huber O (2006). "The histidine triad protein Hint1 triggers apoptosis independent of its enzymatic activity". J. Biol. Chem. 281 (37): 27356–66. doi:10.1074/jbc.M513452200. PMID 16835243.
Ajit SK, Ramineni S, Edris W, et al. (2007). "RGSZ1 interacts with protein kinase C interacting protein PKCI-1 and modulates mu opioid receptor signaling". Cell. Signal. 19 (4): 723–30. doi:10.1016/j.cellsig.2006.09.008. PMID 17126529.
Symes AJ, Eilertsen M, Millar M, et al. (2013). "Quantitative Analysis of BTF3, HINT1, NDRG1 and ODC1 Protein Over-Expression in Human Prostate Cancer Tissue". PLOS ONE. 8 (12): e84295. doi:10.1371/journal.pone.0084295. PMC 3874000. PMID 24386364.

인간 5번 염색체의 유전자에 관한 이 기사는 단조롭다.위키피디아를 확장하여 도울 수 있다.

[refGRCh38Ensembl-1] GRCh38: 앙상블 릴리스 89: ENSG00000169567 - 앙상블, 2017년 5월

[refGRCm38Ensembl-2] GRCm38: 앙상블 릴리스 89: ENSMUSG000020267 - 앙상블, 2017년 5월

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8812426-5] Brzoska PM, Chen H, Levin NA, Kuo WL, Collins C, Fu KK, Gray JW, Christman MF (Feb 1997). "Cloning, mapping, and in vivo localization of a human member of the PKCI-1 protein family (PRKCNH1)". Genomics. 36 (1): 151–6. doi:10.1006/geno.1996.0435. PMID 8812426.

[entrez-6] "Entrez Gene: HINT1 histidine triad nucleotide binding protein 1".

[pmid31990367-7] Strom A, Tong CL, Wagner CR (May 2020). "Histidine triad nucleotide-binding proteins HINT1 and HINT2 share similar substrate specificities and little affinity for the signaling dinucleotide Ap4A". FEBS Letters. 594 (10): 1497–1505. doi:10.1002/1873-3468.13745. PMID 31990367. S2CID 210933742.

[8] "P49773: HINT1 (human)". UniProt.

[pmid19089909-9] Wang L, Li H, Zhang Y, Santella RM, Weinstein IB (Apr 2009). "HINT1 inhibits beta-catenin/TCF4, USF2 and NFkappaB activity in human hepatoma cells". Int J Cancer. 124 (7): 1526–34. doi:10.1002/ijc.24072. PMC 2667231. PMID 19089909.

[pmid14975237-10] Lee YN, Nechushtan H, Figov N, Razin E (Feb 2004). "The function of lysyl-tRNA synthetase and Ap4A as signaling regulators of MITF activity in FcepsilonRI-activated mast cells". Immunity. 20 (2): 145–51. doi:10.1016/S1074-7613(04)00020-2. PMID 14975237.

[pmid19524539-11] Yannay-Cohen N, Carmi-Levy I, Kay G, Yang CM, Han JM, Kemeny DM, Kim S, Nechushtan H, Razin E (June 2009). "LysRS serves as a key signaling molecule in the immune response by regulating gene expression". Mol Cell. 34 (5): 603–11. doi:10.1016/j.molcel.2009.05.019. PMID 19524539.

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힌트1

네임스페이스

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참고 항목

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