간세포증식인자조절티로신인산화효소 기질은 인체 에서 [5] [6] [7] 효소 이다.
상호 작용 HGS는 다음과 대화하는 것 으로 나타났습니다.
레퍼런스 ^ a b c GRCh38: 앙상블 릴리즈 89: ENSG00000185359 - 앙상블 , 2017년 5월^ a b c GRCm38: 앙상블 릴리즈 89: ENSMUSG000025793 - 앙상블 , 2017년 5월^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ a b Asao, H.; Sasaki, Y.; Arita, T.; Tanaka, N.; Endo, K.; Kasai, H.; Takeshita, T.; Endo, Y.; Fujita, T.; Sugamura, K. (1997). "Hrs Is Associated with STAM, a Signal-transducing Adaptor Molecule: Its suppressive effect on cytokine-induced cell growth" . Journal of Biological Chemistry . 272 (52): 32785–32791. doi :10.1074/jbc.272.52.32785 ISSN 0021-9258 . PMID 9407053 . ^ Lu L, Komada M, Kitamura N (August 1998). "Human Hrs, a tyrosine kinase substrate in growth factor-stimulated cells: cDNA cloning and mapping of the gene to chromosome 17". Gene . 213 (1–2): 125–32. doi :10.1016/S0378-1119(98)00184-X . PMID 9630564 . ^ "Entrez Gene: HGS hepatocyte growth factor-regulated tyrosine kinase substrate" .^ Raiborg C, Bache KG, Mehlum A, Stang E, Stenmark H (September 2001). "Hrs recruits clathrin to early endosomes" . EMBO J . 20 (17): 5008–21. doi :10.1093/emboj/20.17.5008 . PMC 125612 PMID 11532964 . ^ Chetkovich DM, Bunn RC, Kuo SH, Kawasaki Y, Kohwi M, Bredt DS (August 2002). "Postsynaptic targeting of alternative postsynaptic density-95 isoforms by distinct mechanisms" . J. Neurosci . 22 (15): 6415–25. doi :10.1523/JNEUROSCI.22-15-06415.2002 PMC 6758133 PMID 12151521 . ^ a b c Bache KG, Raiborg C, Mehlum A, Stenmark H (April 2003). "STAM and Hrs are subunits of a multivalent ubiquitin-binding complex on early endosomes" . J. Biol. Chem . 278 (14): 12513–21. doi :10.1074/jbc.M210843200 PMID 12551915 . ^ Bean AJ, Davanger S, Chou MF, Gerhardt B, Tsujimoto S, Chang Y (May 2000). "Hrs-2 regulates receptor-mediated endocytosis via interactions with Eps15" . J. Biol. Chem . 275 (20): 15271–8. doi :10.1074/jbc.275.20.15271 PMID 10809762 . ^ Yamashita Y, Kojima K, Tsukahara T, Agawa H, Yamada K, Amano Y, Kurotori N, Tanaka N, Sugamura K, Takeshita T (May 2008). "Ubiquitin-independent binding of Hrs mediates endosomal sorting of the interleukin-2 receptor beta-chain" . J. Cell Sci . 121 (Pt 10): 1727–38. doi :10.1242/jcs.024455 PMID 18445679 . ^ Gutmann DH, Haipek CA, Burke SP, Sun CX, Scoles DR, Pulst SM (April 2001). "The NF2 interactor, hepatocyte growth factor-regulated tyrosine kinase substrate (HRS), associates with merlin in the "open" conformation and suppresses cell growth and motility" . Hum. Mol. Genet . 10 (8): 825–34. doi :10.1093/hmg/10.8.825 PMID 11285248 . ^ Scoles DR, Huynh DP, Chen MS, Burke SP, Gutmann DH, Pulst SM (July 2000). "The neurofibromatosis 2 tumor suppressor protein interacts with hepatocyte growth factor-regulated tyrosine kinase substrate" . Hum. Mol. Genet . 9 (11): 1567–74. doi :10.1093/hmg/9.11.1567 PMID 10861283 . ^ a b c Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature . 437 (7062): 1173–8. doi :10.1038/nature04209 . PMID 16189514 . S2CID 4427026 . ^ Lu Q, Hope LW, Brasch M, Reinhard C, Cohen SN (June 2003). "TSG101 interaction with HRS mediates endosomal trafficking and receptor down-regulation" . Proc. Natl. Acad. Sci. U.S.A . 100 (13): 7626–31. doi :10.1073/pnas.0932599100 PMC 164637 PMID 12802020 .
외부 링크 PDBe-KB 는 인간 간세포 성장인자 조절 티로신 키나제 기질(HGS)에 대한 PDB에서 사용 가능한 모든 구조 정보의 개요를 제공합니다.추가 정보 Comoglio PM (1993). "Structure, biosynthesis and biochemical properties of the HGF receptor in normal and malignant cells". EXS . 65 : 131–65. PMID 8380735 . Komada M, Masaki R, Yamamoto A, Kitamura N (1997). "Hrs, a tyrosine kinase substrate with a conserved double zinc finger domain, is localized to the cytoplasmic surface of early endosomes" . J. Biol. Chem . 272 (33): 20538–44. doi :10.1074/jbc.272.33.20538 PMID 9252367 . Stephens DJ, Banting G (1999). "Direct interaction of the trans-Golgi network membrane protein, TGN38, with the F-actin binding protein, neurabin" . J. Biol. Chem . 274 (42): 30080–6. doi :10.1074/jbc.274.42.30080 PMID 10514494 . Bean AJ, Davanger S, Chou MF, Gerhardt B, Tsujimoto S, Chang Y (2000). "Hrs-2 regulates receptor-mediated endocytosis via interactions with Eps15" . J. Biol. Chem . 275 (20): 15271–8. doi :10.1074/jbc.275.20.15271 PMID 10809762 . Kwong J, Roundabush FL, Hutton Moore P, Montague M, Oldham W, Li Y, Chin LS, Li L (2000). "Hrs interacts with SNAP-25 and regulates Ca(2+)-dependent exocytosis" . J. Cell Sci . 113 (12): 2273–84. doi :10.1242/jcs.113.12.2273 . PMID 10825299 . Scoles DR, Huynh DP, Chen MS, Burke SP, Gutmann DH, Pulst SM (2000). "The neurofibromatosis 2 tumor suppressor protein interacts with hepatocyte growth factor-regulated tyrosine kinase substrate" . Hum. Mol. Genet . 9 (11): 1567–74. doi :10.1093/hmg/9.11.1567 PMID 10861283 . Gillooly DJ, Morrow IC, Lindsay M, Gould R, Bryant NJ, Gaullier JM, Parton RG, Stenmark H (2000). "Localization of phosphatidylinositol 3-phosphate in yeast and mammalian cells" . EMBO J . 19 (17): 4577–88. doi :10.1093/emboj/19.17.4577 . PMC 302054 PMID 10970851 . Miura S, Takeshita T, Asao H, Kimura Y, Murata K, Sasaki Y, Hanai JI, Beppu H, Tsukazaki T, Wrana JL, Miyazono K, Sugamura K (2000). "Hgs (Hrs), a FYVE domain protein, is involved in Smad signaling through cooperation with SARA" . Mol. Cell. Biol . 20 (24): 9346–55. doi :10.1128/MCB.20.24.9346-9355.2000 . PMC 102191 PMID 11094085 . Chin LS, Raynor MC, Wei X, Chen HQ, Li L (2001). "Hrs interacts with sorting nexin 1 and regulates degradation of epidermal growth factor receptor" . J. Biol. Chem . 276 (10): 7069–78. doi :10.1074/jbc.M004129200 PMID 11110793 . Gutmann DH, Haipek CA, Burke SP, Sun CX, Scoles DR, Pulst SM (2001). "The NF2 interactor, hepatocyte growth factor-regulated tyrosine kinase substrate (HRS), associates with merlin in the "open" conformation and suppresses cell growth and motility" . Hum. Mol. Genet . 10 (8): 825–34. doi :10.1093/hmg/10.8.825 PMID 11285248 . Sasaki Y, Sugamura K (2001). "Involvement of Hgs/Hrs in signaling for cytokine-mediated c-fos induction through interaction with TAK1 and Pak1" . J. Biol. Chem . 276 (32): 29943–52. doi :10.1074/jbc.M104230200 PMID 11397816 . Raiborg C, Bremnes B, Mehlum A, Gillooly DJ, D'Arrigo A, Stang E, Stenmark H (2001). "FYVE and coiled-coil domains determine the specific localisation of Hrs to early endosomes". J. Cell Sci . 114 (Pt 12): 2255–63. doi :10.1242/jcs.114.12.2255 . PMID 11493665 . Raiborg C, Bache KG, Mehlum A, Stang E, Stenmark H (2001). "Hrs recruits clathrin to early endosomes" . EMBO J . 20 (17): 5008–21. doi :10.1093/emboj/20.17.5008 . PMC 125612 PMID 11532964 . Steen H, Kuster B, Fernandez M, Pandey A, Mann M (2002). "Tyrosine phosphorylation mapping of the epidermal growth factor receptor signaling pathway" . J. Biol. Chem . 277 (2): 1031–9. doi :10.1074/jbc.M109992200 PMID 11687594 . Bishop N, Horman A, Woodman P (2002). "Mammalian class E vps proteins recognize ubiquitin and act in the removal of endosomal protein-ubiquitin conjugates" . J. Cell Biol . 157 (1): 91–101. doi :10.1083/jcb.200112080 . PMC 2173266 PMID 11916981 . Tchernev VT, Mansfield TA, Giot L, Kumar AM, Nandabalan K, Li Y, Mishra VS, Detter JC, Rothberg JM, Wallace MR, Southwick FS, Kingsmore SF (2002). "The Chediak-Higashi protein interacts with SNARE complex and signal transduction proteins" . Mol. Med . 8 (1): 56–64. doi :10.1007/BF03402003 . PMC 2039936 PMID 11984006 . Li Y, Chin LS, Levey AI, Li L (2002). "Huntingtin-associated protein 1 interacts with hepatocyte growth factor-regulated tyrosine kinase substrate and functions in endosomal trafficking" . J. Biol. Chem . 277 (31): 28212–21. doi :10.1074/jbc.M111612200 PMID 12021262 . 
