STAM2

STAM2
사용 가능한 구조
PDB	Ortholog 검색: PDBe RCSB
PDB ID 코드 목록
	1X2Q, 1X5B, 2L0T, 5CRV
식별자
에일리어스	STAM2, Hbp, STAM2A, STAM2B, 신호 변환 어댑터 분자 2
외부 ID	OMIM: 606244 MGI: 1929100 HomoloGene: 68490 GenCard: STAM2
유전자 위치(인간)
크르.	2번 염색체(인간)
끝.	152,175,763 bp
유전자 위치(마우스)
크르.	2번 염색체(마우스)
끝.	52,632,293 bp
RNA발현패턴
	상단 표시 위치:
	아킬레스건; ; 기관지 상피 세포; ; 내장글로부페리더스; ; 난모세포; ; 천측두동맥; ; 이차 난모세포; ; 내피 세포; ; 신장수질; ; 생식 상피; ; 이하선;
	상단 표시 위치:
	정자질; ; 정자 세포; ; 모룰라; ; 송과선; ; 중앙 융기; ; 위상피; ; 하베눌라; ; 정관; ; 이하선; ; 복측 피개부;
	추가 참조 표현식 데이터
	; ; ; ;
	추가 참조 표현식 데이터
유전자 존재론
분자 함수	단백질 결합;
셀룰러 컴포넌트	세포질; ESCRT-0 복합체; 내염색체; 초기 엔도솜막; 세포막내소기관; 막; 핵소체; 세포;
생물학적 과정	단백질 수송; 내염색체수송; 다층체 조립체; 세포내단백질; 표피성장인자수용체신호경로음성조절; 거시 자동 식도; 막구성; 단백질탈유비퀴티네이션;
	출처:아미고 / QuickGO
맞춤법
	10254
	56324
	ENSG00000115145
	ENSMUSG000055371
	O75886
	O88811
	NM_005843
	NM_019667
	NP_005834
	NP_062641
	위키데이터
인간 보기/편집	마우스 표시/편집

신호전달어댑터 분자2는 STAM2 ^[5]^[6]^[7]유전자에 의해 인체 내에서 부호화되는 단백질이다.

기능.

이 유전자에 의해 코드된 단백질은 SH3 도메인과 면역수용체 티로신 기반 활성화 모티브(ITAM)를 모두 포함하는 사이토카인 수용체의 다운스트림 시그널링에 관여하는 어댑터 단백질인 STAM과 밀접하게 관련되어 있다.울레이션따라서 이 단백질과 STAM은 사이토카인 ^[7]자극 시 JAK 키나아제 하류의 신호 경로에 보상 효과를 보이는 것으로 생각된다.

상호 작용

STAM2는 HGS,^[8]^[9] 야누스 키나제^[5]^[6] 1 및 USP8과 ^[10]^[11]상호작용하는 것으로 나타났다.

레퍼런스

^ ^a ^b ^c GRCh38: 앙상블 릴리즈 89: ENSG00000115145 - 앙상블, 2017년 5월
^ ^a ^b ^c GRCm38: 앙상블 릴리즈 89: ENSMUSG000055371 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b Endo K, Takeshita T, Kasai H, Sasaki Y, Tanaka N, Asao H, Kikuchi K, Yamada M, Chenb M, O'Shea JJ, Sugamura K (Jul 2000). "STAM2, a new member of the STAM family, binding to the Janus kinases". FEBS Letters. 477 (1–2): 55–61. doi:10.1016/S0014-5793(00)01760-9. PMID 10899310. S2CID 31811757.
^ ^a ^b Pandey A, Fernandez MM, Steen H, Blagoev B, Nielsen MM, Roche S, Mann M, Lodish HF (Dec 2000). "Identification of a novel immunoreceptor tyrosine-based activation motif-containing molecule, STAM2, by mass spectrometry and its involvement in growth factor and cytokine receptor signaling pathways". The Journal of Biological Chemistry. 275 (49): 38633–9. doi:10.1074/jbc.M007849200. PMID 10993906.
^ ^a ^b "Entrez Gene: STAM2 signal transducing adaptor molecule (SH3 domain and ITAM motif) 2".
^ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
^ Bache KG, Raiborg C, Mehlum A, Stenmark H (Apr 2003). "STAM and Hrs are subunits of a multivalent ubiquitin-binding complex on early endosomes". The Journal of Biological Chemistry. 278 (14): 12513–21. doi:10.1074/jbc.M210843200. PMID 12551915.
^ Kaneko T, Kumasaka T, Ganbe T, Sato T, Miyazawa K, Kitamura N, Tanaka N (Nov 2003). "Structural insight into modest binding of a non-PXXP ligand to the signal transducing adaptor molecule-2 Src homology 3 domain". The Journal of Biological Chemistry. 278 (48): 48162–8. doi:10.1074/jbc.M306677200. PMID 13129930.
^ Kato M, Miyazawa K, Kitamura N (Dec 2000). "A deubiquitinating enzyme UBPY interacts with the Src homology 3 domain of Hrs-binding protein via a novel binding motif PX(V/I)(D/N)RXXKP". The Journal of Biological Chemistry. 275 (48): 37481–7. doi:10.1074/jbc.M007251200. PMID 10982817.

추가 정보

Sulman EP, Tang XX, Allen C, Biegel JA, Pleasure DE, Brodeur GM, Ikegaki N (Mar 1997). "ECK, a human EPH-related gene, maps to 1p36.1, a common region of alteration in human cancers". Genomics. 40 (2): 371–4. doi:10.1006/geno.1996.4569. PMID 9119409.
Kato M, Miyazawa K, Kitamura N (Dec 2000). "A deubiquitinating enzyme UBPY interacts with the Src homology 3 domain of Hrs-binding protein via a novel binding motif PX(V/I)(D/N)RXXKP". The Journal of Biological Chemistry. 275 (48): 37481–7. doi:10.1074/jbc.M007251200. PMID 10982817.
Hartley JL, Temple GF, Brasch MA (Nov 2000). "DNA cloning using in vitro site-specific recombination". Genome Research. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S (Sep 2000). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Reports. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
Steen H, Kuster B, Fernandez M, Pandey A, Mann M (Jan 2002). "Tyrosine phosphorylation mapping of the epidermal growth factor receptor signaling pathway". The Journal of Biological Chemistry. 277 (2): 1031–9. doi:10.1074/jbc.M109992200. PMID 11687594.
Bache KG, Raiborg C, Mehlum A, Stenmark H (Apr 2003). "STAM and Hrs are subunits of a multivalent ubiquitin-binding complex on early endosomes". The Journal of Biological Chemistry. 278 (14): 12513–21. doi:10.1074/jbc.M210843200. PMID 12551915.
Kaneko T, Kumasaka T, Ganbe T, Sato T, Miyazawa K, Kitamura N, Tanaka N (Nov 2003). "Structural insight into modest binding of a non-PXXP ligand to the signal transducing adaptor molecule-2 Src homology 3 domain". The Journal of Biological Chemistry. 278 (48): 48162–8. doi:10.1074/jbc.M306677200. PMID 13129930.
Mizuno E, Kawahata K, Okamoto A, Kitamura N, Komada M (Mar 2004). "Association with Hrs is required for the early endosomal localization, stability, and function of STAM". Journal of Biochemistry. 135 (3): 385–96. doi:10.1093/jb/mvh046. PMID 15113837.
Brill LM, Salomon AR, Ficarro SB, Mukherji M, Stettler-Gill M, Peters EC (May 2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry". Analytical Chemistry. 76 (10): 2763–72. doi:10.1021/ac035352d. PMID 15144186.
Lehner B, Sanderson CM (Jul 2004). "A protein interaction framework for human mRNA degradation". Genome Research. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM (Jul 2004). "Functional proteomics mapping of a human signaling pathway". Genome Research. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A (Oct 2004). "From ORFeome to biology: a functional genomics pipeline". Genome Research. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Lechner MS, Schultz DC, Negorev D, Maul GG, Rauscher FJ (Jun 2005). "The mammalian heterochromatin protein 1 binds diverse nuclear proteins through a common motif that targets the chromoshadow domain". Biochemical and Biophysical Research Communications. 331 (4): 929–37. doi:10.1016/j.bbrc.2005.04.016. PMID 15882967.

외부 링크

UCSC Genome Browser의 STAM2 인간 유전자 위치.
UCSC Genome Browser의 STAM2 인간 유전자 상세.

인간 염색체 2번 유전자에 대한 이 기사는 뭉툭한 것이다.위키피디아를 확장함으로써 위키피디아를 도울 수 있습니다.

[refGRCh38Ensembl-1] GRCh38: 앙상블 릴리즈 89: ENSG00000115145 - 앙상블, 2017년 5월

[refGRCm38Ensembl-2] GRCm38: 앙상블 릴리즈 89: ENSMUSG000055371 - 앙상블, 2017년 5월

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10899310-5] Endo K, Takeshita T, Kasai H, Sasaki Y, Tanaka N, Asao H, Kikuchi K, Yamada M, Chenb M, O'Shea JJ, Sugamura K (Jul 2000). "STAM2, a new member of the STAM family, binding to the Janus kinases". FEBS Letters. 477 (1–2): 55–61. doi:10.1016/S0014-5793(00)01760-9. PMID 10899310. S2CID 31811757.

[pmid10993906-6] Pandey A, Fernandez MM, Steen H, Blagoev B, Nielsen MM, Roche S, Mann M, Lodish HF (Dec 2000). "Identification of a novel immunoreceptor tyrosine-based activation motif-containing molecule, STAM2, by mass spectrometry and its involvement in growth factor and cytokine receptor signaling pathways". The Journal of Biological Chemistry. 275 (49): 38633–9. doi:10.1074/jbc.M007849200. PMID 10993906.

[entrez-7] "Entrez Gene: STAM2 signal transducing adaptor molecule (SH3 domain and ITAM motif) 2".

[pmid16189514-8] Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

[pmid12551915-9] Bache KG, Raiborg C, Mehlum A, Stenmark H (Apr 2003). "STAM and Hrs are subunits of a multivalent ubiquitin-binding complex on early endosomes". The Journal of Biological Chemistry. 278 (14): 12513–21. doi:10.1074/jbc.M210843200. PMID 12551915.

[pmid13129930-10] Kaneko T, Kumasaka T, Ganbe T, Sato T, Miyazawa K, Kitamura N, Tanaka N (Nov 2003). "Structural insight into modest binding of a non-PXXP ligand to the signal transducing adaptor molecule-2 Src homology 3 domain". The Journal of Biological Chemistry. 278 (48): 48162–8. doi:10.1074/jbc.M306677200. PMID 13129930.

[pmid10982817-11] Kato M, Miyazawa K, Kitamura N (Dec 2000). "A deubiquitinating enzyme UBPY interacts with the Src homology 3 domain of Hrs-binding protein via a novel binding motif PX(V/I)(D/N)RXXKP". The Journal of Biological Chemistry. 275 (48): 37481–7. doi:10.1074/jbc.M007251200. PMID 10982817.

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STAM2

네임스페이스

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목차

기능.

상호 작용

레퍼런스

추가 정보

외부 링크