GRAP2
GRAP2| GRAP2 | |||||||||||||||||||||||||
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| 별칭 | GRAP2, GADS, GRAP-2, GRB2L, GRBLG, GRID, GRPL, GrbX, Grf40, 모나, P38, GRB2 관련 어댑터 단백질 2, GRB2 관련 어댑터 단백질 2 | ||||||||||||||||||||||||
| 외부 ID | OMIM: 604518 MGI: 1333842 HomoloGene: 21007 GeneCard: Graph2 | ||||||||||||||||||||||||
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| 종 | 인간 | 마우스 | |||||||||||||||||||||||
| 엔트레스 | |||||||||||||||||||||||||
| 앙상블 | |||||||||||||||||||||||||
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| RefSeq(mRNA) | |||||||||||||||||||||||||
| RefSeq(단백질) | |||||||||||||||||||||||||
| 위치(UCSC) | Cr 22: 39.9 – 39.97Mb | Chr 15: 80.46 – 80.54Mb | |||||||||||||||||||||||
| PubMed 검색 | [3] | [4] | |||||||||||||||||||||||
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Shc(GADS)의 GRB2 관련 어댑터 다운스트림으로도 알려진 GRB2 관련 어댑터 단백질 2는 인간에서 GRAP2 유전자에 의해 인코딩되는 37 kDa 단백질이다.[5][6][7]
함수
이 유전자는 GRB2/Sem5/Drk 계열의 멤버를 인코딩한다.이 부재는 백혈구 특이 단백질-티로신 키나아제 신호에 관여하는 어댑터성 단백질이다.관련 가족 구성원인 GRB2 관련 어댑터 단백질(GRAP)과 마찬가지로 이 단백질은 SH2 도메인을 두 개의 SH3 도메인 옆에 포함한다.이 단백질은 SH3 도메인을 통해 GRB2 관련 결합 단백질 1(GAB1)과 SLP-76 백혈구 단백질(LCP2)과 같은 다른 단백질과 상호작용한다.대체 PolyA 사이트를 활용하는 대본 변형이 존재한다.[7]
상호작용
GRAP2는 다음과 상호 작용하는 것으로 나타났다.
참조
- ^ a b c GRCh38: 앙상블 릴리스 89: ENSG00000100351 - 앙상블, 2017년 5월
- ^ a b c GRCm38: 앙상블 릴리스 89: ENSMUSG000042351 - 앙상블, 2017년 5월
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Qiu M, Hua S, Agrawal M, Li G, Cai J, Chan E, Zhou H, Luo Y, Liu M (Dec 1998). "Molecular cloning and expression of human grap-2, a novel leukocyte-specific SH2- and SH3-containing adaptor-like protein that binds to gab-1". Biochemical and Biophysical Research Communications. 253 (2): 443–7. doi:10.1006/bbrc.1998.9795. PMID 9878555.
- ^ a b c d Asada H, Ishii N, Sasaki Y, Endo K, Kasai H, Tanaka N, Takeshita T, Tsuchiya S, Konno T, Sugamura K (May 1999). "Grf40, A novel Grb2 family member, is involved in T cell signaling through interaction with SLP-76 and LAT". The Journal of Experimental Medicine. 189 (9): 1383–90. doi:10.1084/jem.189.9.1383. PMC 2193052. PMID 10224278.
- ^ a b "Entrez Gene: GRAP2 GRB2-related adaptor protein 2".
- ^ Xia C, Bao Z, Tabassam F, Ma W, Qiu M, Hua S, Liu M (Jul 2000). "GCIP, a novel human grap2 and cyclin D interacting protein, regulates E2F-mediated transcriptional activity". The Journal of Biological Chemistry. 275 (27): 20942–8. doi:10.1074/jbc.M002598200. PMID 10801854.
- ^ a b Ellis JH, Ashman C, Burden MN, Kilpatrick KE, Morse MA, Hamblin PA (Jun 2000). "GRID: a novel Grb-2-related adapter protein that interacts with the activated T cell costimulatory receptor CD28". Journal of Immunology. 164 (11): 5805–14. doi:10.4049/jimmunol.164.11.5805. PMID 10820259.
- ^ a b Liu SK, Fang N, Koretzky GA, McGlade CJ (Jan 1999). "The hematopoietic-specific adaptor protein gads functions in T-cell signaling via interactions with the SLP-76 and LAT adaptors". Current Biology. 9 (2): 67–75. doi:10.1016/s0960-9822(99)80017-7. PMID 10021361.
- ^ a b Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- ^ Ma W, Xia C, Ling P, Qiu M, Luo Y, Tan TH, Liu M (Mar 2001). "Leukocyte-specific adaptor protein Grap2 interacts with hematopoietic progenitor kinase 1 (HPK1) to activate JNK signaling pathway in T lymphocytes". Oncogene. 20 (14): 1703–14. doi:10.1038/sj.onc.1204224. PMID 11313918.
추가 읽기
- Bourette RP, Arnaud S, Myles GM, Blanchet JP, Rohrschneider LR, Mouchiroud G (Dec 1998). "Mona, a novel hematopoietic-specific adaptor interacting with the macrophage colony-stimulating factor receptor, is implicated in monocyte/macrophage development". The EMBO Journal. 17 (24): 7273–81. doi:10.1093/emboj/17.24.7273. PMC 1171073. PMID 9857184.
- Liu SK, McGlade CJ (Dec 1998). "Gads is a novel SH2 and SH3 domain-containing adaptor protein that binds to tyrosine-phosphorylated Shc". Oncogene. 17 (24): 3073–82. doi:10.1038/sj.onc.1202337. PMID 9872323.
- Liu SK, Fang N, Koretzky GA, McGlade CJ (Jan 1999). "The hematopoietic-specific adaptor protein gads functions in T-cell signaling via interactions with the SLP-76 and LAT adaptors". Current Biology. 9 (2): 67–75. doi:10.1016/S0960-9822(99)80017-7. PMID 10021361.
- Law CL, Ewings MK, Chaudhary PM, Solow SA, Yun TJ, Marshall AJ, Hood L, Clark EA (Apr 1999). "GrpL, a Grb2-related adaptor protein, interacts with SLP-76 to regulate nuclear factor of activated T cell activation". The Journal of Experimental Medicine. 189 (8): 1243–53. doi:10.1084/jem.189.8.1243. PMC 2193019. PMID 10209041.
- Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP (Dec 1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208.
- Xia C, Bao Z, Tabassam F, Ma W, Qiu M, Hua S, Liu M (Jul 2000). "GCIP, a novel human grap2 and cyclin D interacting protein, regulates E2F-mediated transcriptional activity". The Journal of Biological Chemistry. 275 (27): 20942–8. doi:10.1074/jbc.M002598200. PMID 10801854.
- Zhang W, Trible RP, Zhu M, Liu SK, McGlade CJ, Samelson LE (Jul 2000). "Association of Grb2, Gads, and phospholipase C-gamma 1 with phosphorylated LAT tyrosine residues. Effect of LAT tyrosine mutations on T cell angigen receptor-mediated signaling". The Journal of Biological Chemistry. 275 (30): 23355–61. doi:10.1074/jbc.M000404200. PMID 10811803.
- Ellis JH, Ashman C, Burden MN, Kilpatrick KE, Morse MA, Hamblin PA (Jun 2000). "GRID: a novel Grb-2-related adapter protein that interacts with the activated T cell costimulatory receptor CD28". Journal of Immunology. 164 (11): 5805–14. doi:10.4049/jimmunol.164.11.5805. PMID 10820259.
- Ma W, Xia C, Ling P, Qiu M, Luo Y, Tan TH, Liu M (Mar 2001). "Leukocyte-specific adaptor protein Grap2 interacts with hematopoietic progenitor kinase 1 (HPK1) to activate JNK signaling pathway in T lymphocytes". Oncogene. 20 (14): 1703–14. doi:10.1038/sj.onc.1204224. PMID 11313918.
- Poetsch A, Molday LL, Molday RS (Dec 2001). "The cGMP-gated channel and related glutamic acid-rich proteins interact with peripherin-2 at the rim region of rod photoreceptor disc membranes". The Journal of Biological Chemistry. 276 (51): 48009–16. doi:10.1074/jbc.M108941200. PMID 11641407.
- Wenzel J, Sanzenbacher R, Ghadimi M, Lewitzky M, Zhou Q, Kaplan DR, Kabelitz D, Feller SM, Janssen O (Dec 2001). "Multiple interactions of the cytosolic polyproline region of the CD95 ligand: hints for the reverse signal transduction capacity of a death factor". FEBS Letters. 509 (2): 255–62. doi:10.1016/S0014-5793(01)03174-X. PMID 11741599.
- Bourgin C, Bourette RP, Arnaud S, Liu Y, Rohrschneider LR, Mouchiroud G (Jun 2002). "Induced expression and association of the Mona/Gads adapter and Gab3 scaffolding protein during monocyte/macrophage differentiation". Molecular and Cellular Biology. 22 (11): 3744–56. doi:10.1128/MCB.22.11.3744-3756.2002. PMC 133813. PMID 11997510.
- Guyot B, Arnaud S, Phothirath P, Bourette RP, Grasset MF, Rigal D, Mouchiroud G (May 2002). "Genomic organization and restricted expression of the human Mona/Gads gene suggests regulation by two specific promoters". Gene. 290 (1–2): 173–9. doi:10.1016/S0378-1119(02)00555-3. PMID 12062812.
- Lindholm CK, Henriksson ML, Hallberg B, Welsh M (Jul 2002). "Shb links SLP-76 and Vav with the CD3 complex in Jurkat T cells". European Journal of Biochemistry. 269 (13): 3279–88. doi:10.1046/j.1432-1033.2002.03008.x. PMID 12084069.
- Zhu M, Janssen E, Leung K, Zhang W (Nov 2002). "Molecular cloning of a novel gene encoding a membrane-associated adaptor protein (LAX) in lymphocyte signaling". The Journal of Biological Chemistry. 277 (48): 46151–8. doi:10.1074/jbc.M208946200. PMID 12359715.
- Guyot B, Arnaud S, Phothirath P, Rigal D, Mouchiroud G (Dec 2002). "Upstream open reading frames regulate translation of Mona/Gads adapter mRNA in the megakaryocytic lineage". Platelets. 13 (8): 459–64. doi:10.1080/0953710021000059431. PMID 12487779.
- Yankee TM, Solow SA, Draves KD, Clark EA (Jan 2003). "Expression of the Grb2-related protein of the lymphoid system in B cell subsets enhances B cell antigen receptor signaling through mitogen-activated protein kinase pathways". Journal of Immunology. 170 (1): 349–55. doi:10.4049/jimmunol.170.1.349. PMID 12496419.
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