ARF GTPase 활성 단백질 GIT1 은 인간에게 GIT1 유전자 에 의해 암호화된 효소 다.[5] [6] [7]
GIT1에는 ARFGAP 도메인, Anykrin repeat 및 GRK 상호 작용 도메인이 포함되어 있다. GTPases의 Arf 계열의 GTPase 활성화 단백질(GAP) 역할을 할 수 있는 Arf-GAP 도메인이 ADRB2의 인산화 및 억제에 관여하는 것으로 나타났다. GIT1의 시냅스 국소화가 교란되면, 이는 백리틱 척추 형태학 및 형성에 영향을 미치는 것으로 알려져 있다-- 이것은 Rac1/PAK1/LIMK/CFL1 경로를 통해 발생하는 것으로 생각된다.[8]
상호작용 GIT1은 다음과 상호 작용하는 것으로 나타났다.
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