호모 사피엔스 종의 단백질 코드 유전자
ADP-리보실화인자결합단백질 GGA2 는 인간 에서 GGA2 [5] [6] [7] 단백질 이다.
기능. 이 유전자는 골지 국소화 감마 어댑틴 귀를 포함한 ARF 결합(GGA) 계열의 구성원을 코드한다. 이 과는 골기 통과 네트워크와 리소좀 사이의 단백질 이동을 조절하는 유비쿼터스 외피 단백질을 포함합니다. 이러한 단백질은 아미노 말단 VHS 도메인을 공유하여 Golgi 네트워크에서 만노스 6-인산 수용체의 분류를 매개한다. 그들은 또한 감마 아답틴의 귀 도메인과 상동성을 갖는 카르복시 말단 영역을 포함한다. 이 패밀리는 화물 분자 조절 및 클래트린 코팅 소포 [7]
상호 작용 GGA2는 RABEP1 ,[8] Sortilin1 ,[9] [10] BACE2 [11] CLINT1 과 [12] [13] 것 으로 나타났습니다.
레퍼런스 ^ a b c GRCh38: 앙상블 릴리즈 89: ENSG00000103365 - 앙상블 , 2017년 5월^ a b c GRCm38: 앙상블 릴리즈 89: ENSMUSG000030872 - 앙상블 , 2017년 5월^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Hirst J, Lui WW, Bright NA, Totty N, Seaman MN, Robinson MS (Apr 2000). "A family of proteins with gamma-adaptin and VHS domains that facilitate trafficking between the trans-Golgi network and the vacuole/lysosome" . The Journal of Cell Biology . 149 (1): 67–80. doi :10.1083/jcb.149.1.67 . PMC 2175106 PMID 10747088 . ^ Boman AL, Zhang CJ, Zhu X, Kahn RA (Apr 2000). "A family of ADP-ribosylation factor effectors that can alter membrane transport through the trans-Golgi" . Molecular Biology of the Cell . 11 (4): 1241–55. doi :10.1091/mbc.11.4.1241 . PMC 14844 PMID 10749927 . ^ a b "Entrez Gene: GGA2 golgi associated, gamma adaptin ear containing, ARF binding protein 2" .^ Mattera R, Arighi CN, Lodge R, Zerial M, Bonifacino JS (Jan 2003). "Divalent interaction of the GGAs with the Rabaptin-5-Rabex-5 complex" . The EMBO Journal . 22 (1): 78–88. doi :10.1093/emboj/cdg015 . PMC 140067 PMID 12505986 . ^ Nielsen MS, Madsen P, Christensen EI, Nykjaer A, Gliemann J, Kasper D, Pohlmann R, Petersen CM (May 2001). "The sortilin cytoplasmic tail conveys Golgi-endosome transport and binds the VHS domain of the GGA2 sorting protein" . The EMBO Journal . 20 (9): 2180–90. doi :10.1093/emboj/20.9.2180 . PMC 125444 PMID 11331584 . ^ Jacobsen L, Madsen P, Nielsen MS, Geraerts WP, Gliemann J, Smit AB, Petersen CM (Jan 2002). "The sorLA cytoplasmic domain interacts with GGA1 and -2 and defines minimum requirements for GGA binding". FEBS Letters . 511 (1–3): 155–8. doi :10.1016/S0014-5793(01)03299-9 . PMID 11821067 . S2CID 21977507 . ^ He X, Chang WP, Koelsch G, Tang J (Jul 2002). "Memapsin 2 (beta-secretase) cytosolic domain binds to the VHS domains of GGA1 and GGA2: implications on the endocytosis mechanism of memapsin 2" . FEBS Letters . 524 (1–3): 183–7. doi :10.1016/S0014-5793(02)03052-1 PMID 12135764 . S2CID 42042430 . ^ Wasiak S, Legendre-Guillemin V, Puertollano R, Blondeau F, Girard M, de Heuvel E, Boismenu D, Bell AW, Bonifacino JS, McPherson PS (Sep 2002). "Enthoprotin: a novel clathrin-associated protein identified through subcellular proteomics" . The Journal of Cell Biology . 158 (5): 855–62. doi :10.1083/jcb.200205078 . PMC 2173151 PMID 12213833 . ^ Kalthoff C, Groos S, Kohl R, Mahrhold S, Ungewickell EJ (Nov 2002). "Clint: a novel clathrin-binding ENTH-domain protein at the Golgi" . Molecular Biology of the Cell . 13 (11): 4060–73. doi :10.1091/mbc.E02-03-0171 . PMC 133614 PMID 12429846 . 추가 정보 Bonaldo MF, Lennon G, Soares MB (Sep 1996). 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"Vear, a novel Golgi-associated protein with VHS and gamma-adaptin "ear" domains" . The Journal of Biological Chemistry . 275 (10): 7176–83. doi :10.1074/jbc.275.10.7176 PMID 10702286 . Dell'Angelica EC, Puertollano R, Mullins C, Aguilar RC, Vargas JD, Hartnell LM, Bonifacino JS (Apr 2000). "GGAs: a family of ADP ribosylation factor-binding proteins related to adaptors and associated with the Golgi complex" . The Journal of Cell Biology . 149 (1): 81–94. doi :10.1083/jcb.149.1.81 . PMC 2175099 PMID 10747089 . Takatsu H, Yoshino K, Nakayama K (May 2000). "Adaptor gamma ear homology domain conserved in gamma-adaptin and GGA proteins that interact with gamma-synergin". Biochemical and Biophysical Research Communications . 271 (3): 719–25. doi :10.1006/bbrc.2000.2700 . PMID 10814529 . Puertollano R, Randazzo PA, Presley JF, Hartnell LM, Bonifacino JS (Apr 2001). "The GGAs promote ARF-dependent recruitment of clathrin to the TGN" . Cell . 105 (1): 93–102. doi :10.1016/S0092-8674(01)00299-9 PMID 11301005 . S2CID 1158816 . Nielsen MS, Madsen P, Christensen EI, Nykjaer A, Gliemann J, Kasper D, Pohlmann R, Petersen CM (May 2001). "The sortilin cytoplasmic tail conveys Golgi-endosome transport and binds the VHS domain of the GGA2 sorting protein" . The EMBO Journal . 20 (9): 2180–90. doi :10.1093/emboj/20.9.2180 . PMC 125444 PMID 11331584 . Puertollano R, Aguilar RC, Gorshkova I, Crouch RJ, Bonifacino JS (Jun 2001). "Sorting of mannose 6-phosphate receptors mediated by the GGAs". Science . 292 (5522): 1712–6. doi :10.1126/science.1060750 . PMID 11387475 . S2CID 30836125 . Zhu Y, Doray B, Poussu A, Lehto VP, Kornfeld S (Jun 2001). "Binding of GGA2 to the lysosomal enzyme sorting motif of the mannose 6-phosphate receptor". Science . 292 (5522): 1716–8. doi :10.1126/science.1060896 . PMID 11387476 . S2CID 9453730 . Takatsu H, Katoh Y, Shiba Y, Nakayama K (Jul 2001). "Golgi-localizing, gamma-adaptin ear homology domain, ADP-ribosylation factor-binding (GGA) proteins interact with acidic dileucine sequences within the cytoplasmic domains of sorting receptors through their Vps27p/Hrs/STAM (VHS) domains" . The Journal of Biological Chemistry . 276 (30): 28541–5. doi :10.1074/jbc.C100218200 PMID 11390366 . Jacobsen L, Madsen P, Nielsen MS, Geraerts WP, Gliemann J, Smit AB, Petersen CM (Jan 2002). "The sorLA cytoplasmic domain interacts with GGA1 and -2 and defines minimum requirements for GGA binding". FEBS Letters . 511 (1–3): 155–8. doi :10.1016/S0014-5793(01)03299-9 . PMID 11821067 . S2CID 21977507 . Doray B, Bruns K, Ghosh P, Kornfeld S (May 2002). "Interaction of the cation-dependent mannose 6-phosphate receptor with GGA proteins" . The Journal of Biological Chemistry . 277 (21): 18477–82. doi :10.1074/jbc.M201879200 PMID 11886874 . Takatsu H, Yoshino K, Toda K, Nakayama K (Jul 2002). "GGA proteins associate with Golgi membranes through interaction between their GGAH domains and ADP-ribosylation factors" . The Biochemical Journal . 365 (Pt 2): 369–78. doi :10.1042/BJ20020428 . PMC 1222692 PMID 11950392 . He X, Chang WP, Koelsch G, Tang J (Jul 2002). "Memapsin 2 (beta-secretase) cytosolic domain binds to the VHS domains of GGA1 and GGA2: implications on the endocytosis mechanism of memapsin 2" . FEBS Letters . 524 (1–3): 183–7. doi :10.1016/S0014-5793(02)03052-1 PMID 12135764 . S2CID 42042430 . Wasiak S, Legendre-Guillemin V, Puertollano R, Blondeau F, Girard M, de Heuvel E, Boismenu D, Bell AW, Bonifacino JS, McPherson PS (Sep 2002). "Enthoprotin: a novel clathrin-associated protein identified through subcellular proteomics" . The Journal of Cell Biology . 158 (5): 855–62. doi :10.1083/jcb.200205078 . PMC 2173151 PMID 12213833 . Kalthoff C, Groos S, Kohl R, Mahrhold S, Ungewickell EJ (Nov 2002). "Clint: a novel clathrin-binding ENTH-domain protein at the Golgi" . Molecular Biology of the Cell . 13 (11): 4060–73. doi :10.1091/mbc.E02-03-0171 . PMC 133614 PMID 12429846 .
PDB 갤러리
1mhq : 인간 GGA2 VHS 도메인의 결정 구조
