호모 사피엔스 종의 단백질 코드 유전자
EPSIN4 로도 알려진 Clathrin interactor 1(CLINT1 )은 사람에게서 CLINT1 [5] [6] [7] 암호화 되는 단백질이다.
기능. CLINT1 단백질은 Clathrin 중쇄 의 말단 도메인에 결합하고 Clathrin 케이지 소포 어셈블리를 자극합니다. 클라트린 코팅 소포를 통해 신경전달물질 수용체와 다른 단백질이 신경막과 다른 유형의 세포막을 가로질러 내구성 또는 흡수될 수 있습니다. 이것은 신경수용체나 다른 단백질의 교체를 유지하게 하고, 따라서 수용체의 수를 미세 [6]
임상적 의의 [8][9][10][11][12]은 항정신병 약물을 클로르 프로 마진과clozapine stabilise 클라 트린 피복 vesicles[13][14]고 왜 항정신병 약물을 망상에 효과적인 이 것이 한가지 이유는 된 환청을 a 알려져 있는 CLINT1 유전자 정신 분열증의 유전적 병인론에 4개의 연구에 참여하게 되는 것으로 나타났다그리고 다른 sympt을 많이 사용한다. 정신분열증 환자요
상호 작용 CLINT1은 GGA2 와 [6] [7] 것 으로 나타났습니다.
레퍼런스 ^ a b c GRCh38: 앙상블 릴리즈 89: ENSG00000113282 - 앙상블 , 2017년 5월^ a b c GRCm38: 앙상블 릴리즈 89: ENSMUSG00000006169 - 앙상블 , 2017년 5월^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Entrez Gene: CLINT1 clathrin interactor 1" .^ a b c Wasiak S, Legendre-Guillemin V, Puertollano R, Blondeau F, Girard M, de Heuvel E, Boismenu D, Bell AW, Bonifacino JS, McPherson PS (September 2002). "Enthoprotin: a novel clathrin-associated protein identified through subcellular proteomics" . J. Cell Biol . 158 (5): 855–62. doi :10.1083/jcb.200205078 . PMC 2173151 PMID 12213833 . ^ a b Kalthoff C, Groos S, Kohl R, Mahrhold S, Ungewickell EJ (November 2002). "Clint: a novel clathrin-binding ENTH-domain protein at the Golgi" . Mol. Biol. Cell . 13 (11): 4060–73. doi :10.1091/mbc.E02-03-0171 . PMC 133614 PMID 12429846 . ^ Pimm J, McQuillin A, Thirumalai S, Lawrence J, Quested D, Bass N, Lamb G, Moorey H, Datta SR, Kalsi G, Badacsonyi A, Kelly K, Morgan J, Punukollu B, Curtis D, Gurling H (May 2005). "The Epsin 4 gene on chromosome 5q, which encodes the clathrin-associated protein enthoprotin, is involved in the genetic susceptibility to schizophrenia" . Am. J. Hum. Genet . 76 (5): 902–7. doi :10.1086/430095 . PMC 1199380 PMID 15793701 . ^ Gurling H, Pimm J, McQuillin A (January 2007). "Replication of genetic association studies between markers at the Epsin 4 gene locus and schizophrenia in two Han Chinese samples". Schizophr. Res . 89 (1–3): 357–9. doi :10.1016/j.schres.2006.08.024 . PMID 17070672 . S2CID 43407088 . ^ Tang RQ, Zhao XZ, Shi YY, Tang W, Gu NF, Feng GY, Xing YL, Zhu SM, Sang H, Liang PJ, He L (April 2006). "Family-based association study of Epsin 4 and Schizophrenia" . Mol. Psychiatry . 11 (4): 395–9. doi :10.1038/sj.mp.4001780 PMID 16402136 . ^ Liou YJ, Lai IC, Wang YC, Bai YM, Lin CC, Lin CY, Chen TT, Chen JY (June 2006). "Genetic analysis of the human ENTH (Epsin 4) gene and schizophrenia". Schizophr. Res . 84 (2–3): 236–43. doi :10.1016/j.schres.2006.02.021 . PMID 16616458 . S2CID 23934037 . ^ Escamilla M, Lee BD, Ontiveros A, Raventos H, Nicolini H, Mendoza R, Jerez A, Munoz R, Medina R, Figueroa A, Walss-Bass C, Armas R, Contreras S, Ramirez ME, Dassori A (December 2008). "The epsin 4 gene is associated with psychotic disorders in families of Latin American origin". Schizophr. Res . 106 (2–3): 253–7. doi :10.1016/j.schres.2008.09.005 . PMID 18929466 . S2CID 24978042 . ^ Phonphok Y, Rosenthal KS (April 1991). "Stabilization of clathrin coated vesicles by amantadine, tromantadine and other hydrophobic amines" . FEBS Lett . 281 (1–2): 188–90. doi :10.1016/0014-5793(91)80390-O PMID 1901801 . S2CID 8197032 . ^ Claing A, Perry SJ, Achiriloaie M, Walker JK, Albanesi JP, Lefkowitz RJ, Premont RT (February 2000). "Multiple endocytic pathways of G protein-coupled receptors delineated by GIT1 sensitivity" . Proc. Natl. Acad. Sci. U.S.A . 97 (3): 1119–24. Bibcode :2000PNAS...97.1119C . doi :10.1073/pnas.97.3.1119 PMC 15541 PMID 10655494 .
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PDB 갤러리
1xgw : 인간 엔트로프로틴 N 말단 도메인의 결정구조
