제타-1 은 [5] [6] [7] FEZ1 유전자에 의해 인체 내에서 암호화되는 단백질 이다.
이 유전자는 C. elegans unc-76 유전자의 직교로, 축삭다발 내의 정상적인 축삭다발과 신장에 필요합니다. C. elegans unc-76 돌연변이에서 이 유전자의 발현은 돌연변이 부분 이동과 축삭 흡착으로 회복될 수 있으며, 축삭 외 성장에서도 기능함을 시사한다. 유전자 생성물의 N 말단 절반은 매우 산성이다. 이 단백질의 다른 동질 형태를 코드하는 대체적으로 스플라이스된 전사 변이가 [7]
이 단백질은 뉴런 에 존재하며,[8] 의한 이러한 세포의 감염 과정을 차단한다고 믿어진다.
상호 작용 FEZ1은 단백질인산화효소 M m,[9] NBR1 [10] [11] DISC1 과 상호작용 하는 것 으로 나타났다.
레퍼런스 ^ a b c GRCh38: 앙상블 릴리즈 89: ENSG00000149557 - 앙상블 , 2017년 5월^ a b c GRCm38: 앙상블 릴리즈 89: ENSMUSG000032118 - 앙상블 , 2017년 5월^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Bloom L, Horvitz HR (May 1997). "The Caenorhabditis elegans gene unc-76 and its human homologs define a new gene family involved in axonal outgrowth and fasciculation" . Proc Natl Acad Sci U S A . 94 (7): 3414–9. Bibcode :1997PNAS...94.3414B . doi :10.1073/pnas.94.7.3414 PMC 20384 PMID 9096408 . ^ Suzuki T, Okada Y, Semba S, Orba Y, Yamanouchi S, Endo S, Tanaka S, Fujita T, Kuroda S, Nagashima K, Sawa H (Jun 2005). "Identification of FEZ1 as a protein that interacts with JC virus agnoprotein and microtubules: role of agnoprotein-induced dissociation of FEZ1 from microtubules in viral propagation" . J Biol Chem . 280 (26): 24948–56. doi :10.1074/jbc.M411499200 PMID 15843383 . ^ a b "Entrez Gene: FEZ1 fasciculation and elongation protein zeta 1 (zygin I)" .^ Haedicke, J.; Brown, C.; Naghavi, M. H. (Aug 2009). "The brain-specific factor FEZ1 is a determinant of neuronal susceptibility to HIV-1 infection" . Proceedings of the National Academy of Sciences . 106 (33): 14040–14045. Bibcode :2009PNAS..10614040H . doi :10.1073/pnas.0900502106 ISSN 0027-8424 . PMC 2729016 PMID 19667186 . ^ Kuroda, S; Nakagawa N; Tokunaga C; Tatematsu K; Tanizawa K (Feb 1999). "Mammalian homologue of the Caenorhabditis elegans UNC-76 protein involved in axonal outgrowth is a protein kinase C zeta-interacting protein" . J. Cell Biol . 144 (3): 403–11. doi :10.1083/jcb.144.3.403 . ISSN 0021-9525 . PMC 2132904 PMID 9971736 . ^ Whitehouse, Caroline; Chambers Julie; Howe Kathy; Cobourne Martyn; Sharpe Paul; Solomon Ellen (Jan 2002). "NBR1 interacts with fasciculation and elongation protein zeta-1 (FEZ1) and calcium and integrin binding protein (CIB) and shows developmentally restricted expression in the neural tube" . Eur. J. Biochem . 269 (2): 538–45. doi :10.1046/j.0014-2956.2001.02681.x ISSN 0014-2956 . PMID 11856312 . ^ Miyoshi, K; Honda A; Baba K; Taniguchi M; Oono K; Fujita T; Kuroda S; Katayama T; Tohyama M (Jul 2003). "Disrupted-In-Schizophrenia 1, a candidate gene for schizophrenia, participates in neurite outgrowth" . Mol. Psychiatry . 8 (7): 685–94. doi :10.1038/sj.mp.4001352 ISSN 1359-4184 . PMID 12874605 .
추가 정보 Kuroda S, Nakagawa N, Tokunaga C, et al. (1999). "Mammalian homologue of the Caenorhabditis elegans UNC-76 protein involved in axonal outgrowth is a protein kinase C zeta-interacting protein" . J. Cell Biol . 144 (3): 403–11. doi :10.1083/jcb.144.3.403 . PMC 2132904 PMID 9971736 . Whitehouse C, Chambers J, Howe K, et al. (2002). "NBR1 interacts with fasciculation and elongation protein zeta-1 (FEZ1) and calcium and integrin binding protein (CIB) and shows developmentally restricted expression in the neural tube" . Eur. J. Biochem . 269 (2): 538–45. doi :10.1046/j.0014-2956.2001.02681.x PMID 11856312 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Miyoshi K, Honda A, Baba K, et al. (2004). "Disrupted-In-Schizophrenia 1, a candidate gene for schizophrenia, participates in neurite outgrowth" . Mol. Psychiatry . 8 (7): 685–94. doi :10.1038/sj.mp.4001352 PMID 12874605 . Surpili MJ, Delben TM, Kobarg J (2004). "Identification of proteins that interact with the central coiled-coil region of the human protein kinase NEK1". Biochemistry . 42 (51): 15369–76. doi :10.1021/bi034575v . PMID 14690447 . Goehler H, Lalowski M, Stelzl U, et al. (2004). "A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease" . Mol. Cell . 15 (6): 853–65. doi :10.1016/j.molcel.2004.09.016 PMID 15383276 . Okumura F, Hatakeyama S, Matsumoto M, et al. (2005). "Functional regulation of FEZ1 by the U-box-type ubiquitin ligase E4B contributes to neuritogenesis" . J. Biol. Chem . 279 (51): 53533–43. doi :10.1074/jbc.M402916200 PMID 15466860 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Yamada K, Nakamura K, Minabe Y, et al. (2005). "Association analysis of FEZ1 variants with schizophrenia in Japanese cohorts". Biol. Psychiatry . 56 (9): 683–90. doi :10.1016/j.biopsych.2004.08.015 . PMID 15522253 . S2CID 42525017 . Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome" . Cell . 122 (6): 957–68. doi :10.1016/j.cell.2005.08.029 . hdl :11858/00-001M-0000-0010-8592-0 PMID 16169070 . S2CID 8235923 . Assmann EM, Alborghetti MR, Camargo ME, Kobarg J (2006). "FEZ1 dimerization and interaction with transcription regulatory proteins involves its coiled-coil region" . J. Biol. Chem . 281 (15): 9869–81. doi :10.1074/jbc.M513280200 PMID 16484223 . Blasius TL, Cai D, Jih GT, et al. (2007). "Two binding partners cooperate to activate the molecular motor Kinesin-1" . J. Cell Biol . 176 (1): 11–7. doi :10.1083/jcb.200605099 . PMC 2063617 PMID 17200414 . Koga M, Ishiguro H, Horiuchi Y, et al. (2007). "Failure to confirm the association between the FEZ1 gene and schizophrenia in a Japanese population". Neurosci. Lett . 417 (3): 326–9. doi :10.1016/j.neulet.2007.02.055 . PMID 17374448 . S2CID 33689793 .
