Epsin-2 는 EPN2 [5] [6] 단백질 이다.
이 유전자는 클라트린 및 어댑터 관련 단백질 복합체 2, 알파 1 서브유닛과 상호작용하는 단백질을 암호화한다. 이 단백질은 뇌에서 유래한 클라트린으로 코팅된 소포 분율에서 발견되며 골기 주변 영역과 세포 주변 에 국소화된다. 그 단백질은 클라트린 매개성 엔도사이토시스 (Endocytosis)에 관여하는 것으로 생각된다. 이 유전자의 대체 스플라이싱은 다른 아이소폼 을 [6] 개의 전사 변이체를 낳는다.
레퍼런스 ^ a b c GRCh38: 앙상블 릴리즈 89: ENSG000072134 - 앙상블 , 2017년 5월^ a b c GRCm38: 앙상블 릴리즈 89: ENSMUSG00000001036 - 앙상블 , 2017년 5월^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Rosenthal JA, Chen H, Slepnev VI, Pellegrini L, Salcini AE, Di Fiore PP, De Camilli P (Dec 1999). "The epsins define a family of proteins that interact with components of the clathrin coat and contain a new protein module" . J Biol Chem . 274 (48): 33959–65. doi :10.1074/jbc.274.48.33959 PMID 10567358 . ^ a b "Entrez Gene: EPN2 epsin 2" . 추가 정보 Salcini AE, Confalonieri S, Doria M, et al. (1997). "Binding specificity and in vivo targets of the EH domain, a novel protein–protein interaction module" . Genes Dev . 11 (17): 2239–49. doi :10.1101/gad.11.17.2239 . PMC 275390 PMID 9303539 . Yamabhai M, Hoffman NG, Hardison NL, et al. (1998). "Intersectin, a novel adaptor protein with two Eps15 homology and five Src homology 3 domains" . J. Biol. Chem . 273 (47): 31401–7. doi :10.1074/jbc.273.47.31401 PMID 9813051 . Kikuno R, Nagase T, Ishikawa K, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro" . DNA Res . 6 (3): 197–205. doi :10.1093/dnares/6.3.197 PMID 10470851 . Ford MG, Mills IG, Peter BJ, et al. (2002). "Curvature of clathrin-coated pits driven by epsin". Nature . 419 (6905): 361–6. doi :10.1038/nature01020 . PMID 12353027 . S2CID 4372368 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Hussain NK, Yamabhai M, Bhakar AL, et al. (2003). "A role for epsin N-terminal homology/AP180 N-terminal homology (ENTH/ANTH) domains in tubulin binding" . J. Biol. Chem . 278 (31): 28823–30. doi :10.1074/jbc.M300995200 PMID 12750376 . Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5. doi :10.1038/ng1285 PMID 14702039 . Colland F, Jacq X, Trouplin V, et al. (2004). "Functional Proteomics Mapping of a Human Signaling Pathway" . Genome Res . 14 (7): 1324–32. doi :10.1101/gr.2334104 . PMC 442148 PMID 15231748 . Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol . 14 (16): 1436–50. doi :10.1016/j.cub.2004.07.051 . PMID 15324660 . S2CID 2371325 . Ballif BA, Villén J, Beausoleil SA, et al. (2005). "Phosphoproteomic analysis of the developing mouse brain" . Mol. Cell. Proteomics . 3 (11): 1093–101. doi :10.1074/mcp.M400085-MCP200 PMID 15345747 . Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes" . Genome Res . 16 (1): 55–65. doi :10.1101/gr.4039406 . PMC 1356129 PMID 16344560 . Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks" . Cell . 127 (3): 635–48. doi :10.1016/j.cell.2006.09.026 PMID 17081983 . S2CID 7827573 .
