DVL2
DVL2
세그먼트 극성 단백질 디굴레드 호몰로그 DVL-2는 인간에서 DVL2 [5][6]유전자에 의해 암호화되는 단백질이다.
이 유전자는 분열된 단백질 계열의 일원을 암호화한다.척추동물 dsh 단백질은 드로소필라 dsh와 약 40%의 아미노산 배열 유사성을 가진다.이 유전자는 번역 후 인산화 과정을 거치는 90kD 단백질을 암호화하여 95kD 세포질 단백질을 형성하며, 이는 여러 Wnt 단백질에 의해 매개되는 신호 전달 경로에서 역할을 할 수 있다.Wnt 시그널링에서의 디세블링 기능의 메커니즘은 [6]메타조안들 사이에서 보존될 가능성이 있다.
상호 작용
DVL2는 아연 핑거 단백질 165,[7] DAB2[8], 아레스틴 베타 [9]1과 상호작용하는 것으로 나타났습니다.
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레퍼런스
- ^ a b c GRCh38: 앙상블 릴리즈 89: ENSG00000004975 - 앙상블, 2017년 5월
- ^ a b c GRCm38: 앙상블 릴리즈 89: ENSMUSG000020888 - 앙상블, 2017년 5월
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Greco TL, Sussman DJ, Camper SA (January 1997). "Dishevelled-2 maps to human chromosome 17 and distal to Wnt3a and vestigial tail (vt) on mouse chromosome 11". Mamm Genome. 7 (6): 475–6. doi:10.1007/s003359900144. PMID 8662242. S2CID 39619679.
- ^ a b "Entrez Gene: DVL2 dishevelled, dsh homolog 2 (Drosophila)".
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- ^ Hocevar, B A; Mou F; Rennolds J L; Morris S M; Cooper J A; Howe P H (June 2003). "Regulation of the Wnt signaling pathway by disabled-2 (Dab2)". EMBO J. 22 (12): 3084–94. doi:10.1093/emboj/cdg286. ISSN 0261-4189. PMC 162138. PMID 12805222.
- ^ Chen, W; Hu L A; Semenov M V; Yanagawa S; Kikuchi A; Lefkowitz R J; Miller W E (December 2001). "β-Arrestin1 modulates lymphoid enhancer factor transcriptional activity through interaction with phosphorylated dishevelled proteins". Proc. Natl. Acad. Sci. U.S.A. 98 (26): 14889–94. Bibcode:2001PNAS...9814889C. doi:10.1073/pnas.211572798. ISSN 0027-8424. PMC 64954. PMID 11742073.
추가 정보
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