다즐

다즐
사용 가능한 구조
PDB	휴먼 유니프로트 검색: PDBe RCSB
PDB ID 코드 목록
	2XS2, 2XS5, 2XS7, 2XSF
식별자
에일리어스	DAZL, DAZH, DAZL1, DAZLA, SPGYLA, 무조류 혈청에서 삭제됨
외부 ID	OMIM : 601486 HomoloGene : 1034 GenCard : DAZL
유전자 위치(인간)
크르.	3번 염색체(인간)
끝.	16,670,306 bp
RNA발현패턴
	상단 표시 위치:
	난모세포; ; 이차 난모세포; ; 정자; ; 부록; ; 메타네프로스; ; 림프절; ; 근육 조직; ; 직장; ; 십이지장; ; 태반;
	추가 참조 표현식 데이터
	추가 참조 표현식 데이터
유전자 존재론
분자 함수	핵산 결합; GO:0001948 단백질 결합; RNA결합; 번역 액티베이터 액티비티; 동일단백질결합; mRNA3'-UTR결합; mRNA 결합;
셀룰러 컴포넌트	핵; 폴리섬; 세포질; 세포내 해부학적 구조; 단백질 함유 복합체;
생물학적 과정	다세포 생물 발달; 세포 분화; 번역 규제; 정자 형성; 난모세포 성숙; 여성 감수 분열 II; 생식 세포 발달; 감수 분열의 양성 조절; 번역 개시의 적극적인 조절; 3'-UTR 매개 mRNA 안정화;
	출처:아미고 / QuickGO
맞춤법
	1618
	없음
	ENSG00000092345
	없음
	문제 92904
	없음
	NM_001351; NM_001190811
	없음
	NP_00117740; NP_001342
	없음
	위키데이터
인간 보기/편집

무조혈증 유사 단백질은 DAZL ^[3]유전자에 의해 인간에서 코드되는 단백질이다.

기능.

DAZ(AZoospermia에서 결손) 유전자 패밀리는 남성과 여성의 태아 및 산후 생식 세포에서 발현되는 잠재적 RNA 결합 단백질을 암호화합니다.이 유전자에 의해 코드된 단백질은 태아 생식세포의 핵과 세포질, 그리고 발달하는 난모세포의 세포질에 국소화된다.고환에서 이 단백질은 정조세포의 핵에 국소화되지만 감수분열 시 세포질로 이동하며 정조세포와 정자에 잔류한다.영장류 진화 중 이 상염색체 유전자의 전이와 증폭은 Y 염색체 상의 DAZ 유전자 클러스터를 발생시켰다.이 유전자의 돌연변이는 남성의 ^[4]심각한 정자성 기능 상실과 불임과 관련이 있다.

DAZL이 결핍된 생쥐와 돼지에서 PGC는 생식선으로 이동하지만 생식 세포 결정을 수행하지 않으며 대신 생식 세포 ^[5]종양을 생성할 수 있다.

상호 작용

DAZL은 DAZ1과 ^[6]^[7]상호작용하는 것으로 나타났다.

레퍼런스

^ ^a ^b ^c GRCh38: 앙상블 릴리즈 89: ENSG00000092345 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Saxena R, Brown LG, Hawkins T, Alagappan RK, Skaletsky H, Reeve MP, Reijo R, Rozen S, Dinulos MB, Disteche CM, Page DC (Nov 1996). "The DAZ gene cluster on the human Y chromosome arose from an autosomal gene that was transposed, repeatedly amplified and pruned". Nature Genetics. 14 (3): 292–9. doi:10.1038/ng1196-292. PMID 8896558. S2CID 34964224.
^ "Entrez Gene: DAZL deleted in azoospermia-like".
^ Nicholls, Peter K.; Schorle, Hubert; Naqvi, Sahin; Hu, Yueh-Chiang; Fan, Yuting; Carmell, Michelle A.; Dobrinski, Ina; Watson, Adrienne L.; Carlson, Daniel F.; Fahrenkrug, Scott C.; Page, David C. (2019-11-21). "Mammalian germ cells are determined after PGC colonization of the nascent gonad". Proceedings of the National Academy of Sciences. 116 (51): 25677–25687. doi:10.1073/pnas.1910733116. ISSN 0027-8424. PMC 6925976. PMID 31754036.
^ Ruggiu M, Cooke HJ (Jul 2000). "In vivo and in vitro analysis of homodimerisation activity of the mouse Dazl1 protein". Gene. 252 (1–2): 119–26. doi:10.1016/S0378-1119(00)00219-5. PMID 10903443.
^ Tsui S, Dai T, Roettger S, Schempp W, Salido EC, Yen PH (May 2000). "Identification of two novel proteins that interact with germ-cell-specific RNA-binding proteins DAZ and DAZL1". Genomics. 65 (3): 266–73. doi:10.1006/geno.2000.6169. PMID 10857750.

추가 정보

Shan Z, Hirschmann P, Seebacher T, Edelmann A, Jauch A, Morell J, Urbitsch P, Vogt PH (Dec 1996). "A SPGY copy homologous to the mouse gene Dazla and the Drosophila gene boule is autosomal and expressed only in the human male gonad". Human Molecular Genetics. 5 (12): 2005–11. doi:10.1093/hmg/5.12.2005. PMID 8968755.
Yen PH, Chai NN, Salido EC (Dec 1996). "The human autosomal gene DAZLA: testis specificity and a candidate for male infertility". Human Molecular Genetics. 5 (12): 2013–7. doi:10.1093/hmg/5.12.2013. PMID 8968756.
Seboun E, Barbaux S, Bourgeron T, Nishi S, Agulnik A, Egashira M, Nikkawa N, Bishop C, Fellous M, McElreavey K, Kasahara M, Algonik A (Apr 1997). "Gene sequence, localization, and evolutionary conservation of DAZLA, a candidate male sterility gene". Genomics. 41 (2): 227–35. doi:10.1006/geno.1997.4635. PMID 9143498.
Ruggiu M, Speed R, Taggart M, McKay SJ, Kilanowski F, Saunders P, Dorin J, Cooke HJ (Sep 1997). "The mouse Dazla gene encodes a cytoplasmic protein essential for gametogenesis". Nature. 389 (6646): 73–7. Bibcode:1997Natur.389...73R. doi:10.1038/37987. PMID 9288969. S2CID 8809115.
Chai NN, Phillips A, Fernandez A, Yen PH (Aug 1997). "A putative human male infertility gene DAZLA: genomic structure and methylation status". Molecular Human Reproduction. 3 (8): 705–8. doi:10.1093/molehr/3.8.705. PMID 9294855. S2CID 3489111.
Agulnik AI, Zharkikh A, Boettger-Tong H, Bourgeron T, McElreavey K, Bishop CE (Sep 1998). "Evolution of the DAZ gene family suggests that Y-linked DAZ plays little, or a limited, role in spermatogenesis but underlines a recent African origin for human populations". Human Molecular Genetics. 7 (9): 1371–7. doi:10.1093/hmg/7.9.1371. PMID 9700189.
Nishi S, Hoshi N, Kasahara M, Ishibashi T, Fujimoto S (Jun 1999). "Existence of human DAZLA protein in the cytoplasm of human oocytes". Molecular Human Reproduction. 5 (6): 495–7. doi:10.1093/molehr/5.6.495. PMID 10340994.
Slee R, Grimes B, Speed RM, Taggart M, Maguire SM, Ross A, McGill NI, Saunders PT, Cooke HJ (Jul 1999). "A human DAZ transgene confers partial rescue of the mouse Dazl null phenotype". Proceedings of the National Academy of Sciences of the United States of America. 96 (14): 8040–5. Bibcode:1999PNAS...96.8040S. doi:10.1073/pnas.96.14.8040. PMC 22184. PMID 10393944.
Dorfman DM, Genest DR, Reijo Pera RA (Oct 1999). "Human DAZL1 encodes a candidate fertility factor in women that localizes to the prenatal and postnatal germ cells". Human Reproduction. 14 (10): 2531–6. doi:10.1093/humrep/14.10.2531. PMID 10527983.
Tsai MY, Chang SY, Lo HY, Chen IH, Huang FJ, Kung FT, Lu YJ (Mar 2000). "The expression of DAZL1 in the ovary of the human female fetus". Fertility and Sterility. 73 (3): 627–30. doi:10.1016/S0015-0282(99)00544-0. PMID 10689024.
Brekhman V, Itskovitz-Eldor J, Yodko E, Deutsch M, Seligman J (May 2000). "The DAZL1 gene is expressed in human male and female embryonic gonads before meiosis". Molecular Human Reproduction. 6 (5): 465–8. doi:10.1093/molehr/6.5.465. PMID 10775651. S2CID 17223133.
Ruggiu M, Saunders PT, Cooke HJ (2000). "Dynamic subcellular distribution of the DAZL protein is confined to primate male germ cells". Journal of Andrology. 21 (3): 470–7. PMID 10819456.
Tsui S, Dai T, Warren ST, Salido EC, Yen PH (Jun 2000). "Association of the mouse infertility factor DAZL1 with actively translating polyribosomes". Biology of Reproduction. 62 (6): 1655–60. doi:10.1095/biolreprod62.6.1655. PMID 10819768.
Tsui S, Dai T, Roettger S, Schempp W, Salido EC, Yen PH (May 2000). "Identification of two novel proteins that interact with germ-cell-specific RNA-binding proteins DAZ and DAZL1". Genomics. 65 (3): 266–73. doi:10.1006/geno.2000.6169. PMID 10857750.
Ruggiu M, Cooke HJ (Jul 2000). "In vivo and in vitro analysis of homodimerisation activity of the mouse Dazl1 protein". Gene. 252 (1–2): 119–26. doi:10.1016/S0378-1119(00)00219-5. PMID 10903443.
Reijo RA, Dorfman DM, Slee R, Renshaw AA, Loughlin KR, Cooke H, Page DC (Nov 2000). "DAZ family proteins exist throughout male germ cell development and transit from nucleus to cytoplasm at meiosis in humans and mice". Biology of Reproduction. 63 (5): 1490–6. doi:10.1095/biolreprod63.5.1490. PMID 11058556.
Xu EY, Moore FL, Pera RA (Jun 2001). "A gene family required for human germ cell development evolved from an ancient meiotic gene conserved in metazoans". Proceedings of the National Academy of Sciences of the United States of America. 98 (13): 7414–9. Bibcode:2001PNAS...98.7414Y. doi:10.1073/pnas.131090498. PMC 34683. PMID 11390979.
Van Golde RJ, Tuerlings JH, Kremer JA, Braat DD, Schoute F, Hoefsloot LH (Jul 2001). "DAZLA: an important candidate gene in male subfertility?". Journal of Assisted Reproduction and Genetics. 18 (7): 395–9. doi:10.1023/A:1016678624225. PMC 3455824. PMID 11499325.
Lin YM, Chen CW, Sun HS, Tsai SJ, Hsu CC, Teng YN, Lin JS, Kuo PL (Nov 2001). "Expression patterns and transcript concentrations of the autosomal DAZL gene in testes of azoospermic men". Molecular Human Reproduction. 7 (11): 1015–22. doi:10.1093/molehr/7.11.1015. PMID 11675467.

인간 염색체 3번 유전자에 대한 이 기사는 뭉툭한 것이다.위키피디아를 확장함으로써 위키피디아를 도울 수 있습니다.

[refGRCh38Ensembl-1] GRCh38: 앙상블 릴리즈 89: ENSG00000092345 - 앙상블, 2017년 5월

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8896558-3] Saxena R, Brown LG, Hawkins T, Alagappan RK, Skaletsky H, Reeve MP, Reijo R, Rozen S, Dinulos MB, Disteche CM, Page DC (Nov 1996). "The DAZ gene cluster on the human Y chromosome arose from an autosomal gene that was transposed, repeatedly amplified and pruned". Nature Genetics. 14 (3): 292–9. doi:10.1038/ng1196-292. PMID 8896558. S2CID 34964224.

[entrez-4] "Entrez Gene: DAZL deleted in azoospermia-like".

[5] Nicholls, Peter K.; Schorle, Hubert; Naqvi, Sahin; Hu, Yueh-Chiang; Fan, Yuting; Carmell, Michelle A.; Dobrinski, Ina; Watson, Adrienne L.; Carlson, Daniel F.; Fahrenkrug, Scott C.; Page, David C. (2019-11-21). "Mammalian germ cells are determined after PGC colonization of the nascent gonad". Proceedings of the National Academy of Sciences. 116 (51): 25677–25687. doi:10.1073/pnas.1910733116. ISSN 0027-8424. PMC 6925976. PMID 31754036.

[pmid10903443-6] Ruggiu M, Cooke HJ (Jul 2000). "In vivo and in vitro analysis of homodimerisation activity of the mouse Dazl1 protein". Gene. 252 (1–2): 119–26. doi:10.1016/S0378-1119(00)00219-5. PMID 10903443.

[pmid10857750-7] Tsui S, Dai T, Roettger S, Schempp W, Salido EC, Yen PH (May 2000). "Identification of two novel proteins that interact with germ-cell-specific RNA-binding proteins DAZ and DAZL1". Genomics. 65 (3): 266–73. doi:10.1006/geno.2000.6169. PMID 10857750.

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