호모 사피엔스 종의 단백질 코드 유전자
Classin 은 인간 에게서 CLSPN 유전자에 [5] [6] [7] 암호화 되는 단백질이다.
기능. 다크[7]
상호 작용 CLSPN은 다음과 상호작용하는 것 으로 나타났습니다.
레퍼런스 ^ a b c GRCh38: 앙상블 릴리즈 89: ENSG00000092853 - 앙상블 , 2017년 5월^ a b c GRCm38: 앙상블 릴리즈 89: ENSMUSG000042489 - 앙상블 , 2017년 5월^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Kumagai A, Dunphy WG (Nov 2000). "Claspin, a novel protein required for the activation of Chk1 during a DNA replication checkpoint response in Xenopus egg extracts" . Mol Cell . 6 (4): 839–49. doi :10.1016/S1097-2765(05)00092-4 PMID 11090622 . ^ a b Chini CC, Chen J (Aug 2003). "Human claspin is required for replication checkpoint control" . J Biol Chem . 278 (32): 30057–62. doi :10.1074/jbc.M301136200 PMID 12766152 . ^ a b "Entrez Gene: CLSPN claspin homolog (Xenopus laevis)" .^ Lin SY, Li K, Stewart GS, Elledge SJ (2004). "Human Claspin works with BRCA1 to both positively and negatively regulate cell proliferation" . Proc. Natl. Acad. Sci. U.S.A . 101 (17): 6484–9. Bibcode :2004PNAS..101.6484L . doi :10.1073/pnas.0401847101 PMC 404071 PMID 15096610 . ^ a b c Serçin O, Kemp MG (May 2011). "Characterization of functional domains in human Claspin" . Cell Cycle . 10 (10): 1599–606. doi :10.4161/cc.10.10.15562 . PMC 3127160 PMID 21478680 . ^ Faustrup H, Bekker-Jensen S, Bartek J, Lukas J, Mailand N (2009). "USP7 counteracts SCFbetaTrCP- but not APCCdh1-mediated proteolysis of Claspin" . J. Cell Biol . 184 (1): 13–9. doi :10.1083/jcb.200807137 . PMC 2615094 PMID 19124652 . 외부 링크 추가 정보 Chini CC, Chen J (2005). "Claspin, a regulator of Chk1 in DNA replication stress pathway". DNA Repair (Amst.) . 3 (8–9): 1033–7. doi :10.1016/j.dnarep.2004.03.001 . PMID 15279790 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Lin SY, Li K, Stewart GS, Elledge SJ (2004). "Human Claspin works with BRCA1 to both positively and negatively regulate cell proliferation" . Proc. Natl. Acad. Sci. U.S.A . 101 (17): 6484–9. Bibcode :2004PNAS..101.6484L . doi :10.1073/pnas.0401847101 PMC 404071 PMID 15096610 . Sørensen CS, Syljuåsen RG, Lukas J, Bartek J (2006). "ATR, Claspin and the Rad9-Rad1-Hus1 complex regulate Chk1 and Cdc25A in the absence of DNA damage" . Cell Cycle . 3 (7): 941–5. doi :10.4161/cc.3.7.972 PMID 15190204 . Sar F, Lindsey-Boltz LA, Subramanian D, et al. (2004). "Human claspin is a ring-shaped DNA-binding protein with high affinity to branched DNA structures" . J. Biol. Chem . 279 (38): 39289–95. doi :10.1074/jbc.M405793200 PMID 15226314 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Clarke CA, Clarke PR (2005). "DNA-dependent phosphorylation of Chk1 and Claspin in a human cell-free system" . Biochem. J . 388 (Pt 2): 705–12. doi :10.1042/BJ20041966 . PMC 1138979 PMID 15707391 . Clarke CA, Bennett LN, Clarke PR (2005). "Cleavage of claspin by caspase-7 during apoptosis inhibits the Chk1 pathway" . J. Biol. Chem . 280 (42): 35337–45. doi :10.1074/jbc.M506460200 PMID 16123041 . Chini CC, Wood J, Chen J (2006). "Chk1 is required to maintain claspin stability" . Oncogene . 25 (30): 4165–71. doi :10.1038/sj.onc.1209447 PMID 16501606 . Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1" . Nature . 441 (7091): 315–21. Bibcode :2006Natur.441..315G . doi :10.1038/nature04727 PMID 16710414 . Bennett LN, Clarke PR (2006). "Regulation of Claspin degradation by the ubiquitin-proteosome pathway during the cell cycle and in response to ATR-dependent checkpoint activation" . FEBS Lett . 580 (17): 4176–81. doi :10.1016/j.febslet.2006.06.071 PMID 16828751 . Liu S, Bekker-Jensen S, Mailand N, et al. (2006). "Claspin operates downstream of TopBP1 to direct ATR signaling towards Chk1 activation" . Mol. Cell. Biol . 26 (16): 6056–64. doi :10.1128/MCB.00492-06 . PMC 1592810 PMID 16880517 . Mailand N, Bekker-Jensen S, Bartek J, Lukas J (2006). "Destruction of Claspin by SCFbetaTrCP restrains Chk1 activation and facilitates recovery from genotoxic stress" . Mol. Cell . 23 (3): 307–18. doi :10.1016/j.molcel.2006.06.016 PMID 16885021 . Peschiaroli A, Dorrello NV, Guardavaccaro D, et al. (2006). "SCFbetaTrCP-mediated degradation of Claspin regulates recovery from the DNA replication checkpoint response" . Mol. Cell . 23 (3): 319–29. doi :10.1016/j.molcel.2006.06.013 PMID 16885022 . Mamely I, van Vugt MA, Smits VA, et al. (2006). "Polo-like kinase-1 controls proteasome-dependent degradation of Claspin during checkpoint recovery" . Curr. Biol . 16 (19): 1950–5. doi :10.1016/j.cub.2006.08.026 PMID 16934469 . Rodríguez-Bravo V, Guaita-Esteruelas S, Florensa R, et al. (2007). "Chk1- and claspin-dependent but ATR/ATM- and Rad17-independent DNA replication checkpoint response in HeLa cells" . Cancer Res . 66 (17): 8672–9. doi :10.1158/0008-5472.CAN-05-4443 PMID 16951182 . Chini CC, Chen J (2006). "Repeated phosphopeptide motifs in human Claspin are phosphorylated by Chk1 and mediate Claspin function" . J. Biol. Chem . 281 (44): 33276–82. doi :10.1074/jbc.M604373200 PMID 16963448 . Sercin O, Kemp MG (2011). "Characterization of functional domains in human Claspin" . Cell Cycle . 10 (10): 1599–606. doi :10.4161/cc.10.10.15562 . PMC 3127160 PMID 21478680 .
