샤프1B

샤프1B
식별자
에일리어스	CHAF1B, CAF-1, CAF-IP60, CAF1, CAF1A, CAF1P60, MPHOSP7, 크로마틴 조립 계수 1 하위 단위 B
외부 ID	OMIM : 601245 MGI : 1314881 HomoloGene : 48346 Genecard : CHAF1B
유전자 위치(인간)
크르.	21번 염색체(인간)
끝.	36,419,015 bp
유전자 위치(마우스)
크르.	16번 염색체(쥐)
끝.	93,703,003 bp
RNA발현패턴
	상단 표시 위치:
	이차 난모세포; ; 위근; ; 신경절 융기; ; 자궁내막간질세포; ; 골격근 조직; ; 랑게르한스 섬; ; 소뇌 반구; ; 뼈.; ; 골수; ; 소침샘;
	추가 참조 표현식 데이터
	추가 참조 표현식 데이터
유전자 존재론
분자 함수	전개단백질결합; 히스톤 결합; 크로마틴 결합; GO:0001948 단백질 결합;
셀룰러 컴포넌트	세포질; 세포; CAF-1 복합체; 핵소체; 핵; 단백질 함유 복합체;
생물학적 과정	크로마틴 조립체; 전사조절, DNA템플릿화; 전사, DNA 템플릿; DNA 손상 자극에 대한 세포 반응; DNA복제 의존성 크로마틴 조립체; DNA복제; 세포 주기; DNA복구; 뉴클레오솜 조립체;
	출처:아미고 / QuickGO
맞춤법
	8208
	110749
	ENSG00000159259
	ENSMUSG000022945
	문제 13112
	Q9D0N7
	NM_005441
	NM_028083
	NP_005432
	NP_082359
	위키데이터
인간 보기/편집	마우스 표시/편집

크로마틴 조립인자 1 서브유닛 B는 CHAF1B ^[5]^[6]^[7]유전자에 의해 인체 내에서 암호화되는 단백질이다.

기능.

새롭게 복제된 DNA에 히스톤 옥타머를 조립하기 위해서는 크로마틴 조립인자 I(CAF-1)가 필요하며, CAF-I는 3개의 단백질 서브유닛, p50, p60, p150으로 구성되어 있다.이 유전자에 의해 암호화된 단백질은 p60 서브유닛에 해당하며 복제 후 염색질 조립에 필요하다.암호화된 단백질은 세포 주기 의존적인 방식으로 차등적으로 인산화된다.게다가, 그것은 세포질로 방출되는 유사분열 때를 제외하고 보통 핵에서 발견됩니다.이 단백질은 WD 반복 HIR1 패밀리의 일종으로 DNA ^[7]수복에도 관여할 수 있습니다.

상호 작용

CHAF1B는 다음과 상호작용하는 것으로 나타났습니다.

레퍼런스

^ ^a ^b ^c GRCh38: 앙상블 릴리즈 89: ENSG00000159259 - 앙상블, 2017년 5월
^ ^a ^b ^c GRCm38: 앙상블 릴리즈 89: ENSMUSG000022945 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Kaufman PD, Kobayashi R, Kessler N, Stillman B (Jun 1995). "The p150 and p60 subunits of chromatin assembly factor I: a molecular link between newly synthesized histones and DNA replication". Cell. 81 (7): 1105–14. doi:10.1016/S0092-8674(05)80015-7. PMID 7600578. S2CID 13502921.
^ Katsanis N, Fisher EM (Oct 1996). "The gene encoding the p60 subunit of chromatin assembly factor I (CAF1P60) maps to human chromosome 21q22.2, a region associated with some of the major features of Down syndrome". Human Genetics. 98 (4): 497–9. doi:10.1007/s004390050246. PMID 8792829. S2CID 1206979.
^ ^a ^b "Entrez Gene: CHAF1B chromatin assembly factor 1, subunit B (p60)".
^ ^a ^b Mello JA, Silljé HH, Roche DM, Kirschner DB, Nigg EA, Almouzni G (Apr 2002). "Human Asf1 and CAF-1 interact and synergize in a repair-coupled nucleosome assembly pathway". EMBO Reports. 3 (4): 329–34. doi:10.1093/embo-reports/kvf068. PMC 1084056. PMID 11897662.
^ Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3: 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
^ Kitagawa H, Fujiki R, Yoshimura K, Mezaki Y, Uematsu Y, Matsui D, Ogawa S, Unno K, Okubo M, Tokita A, Nakagawa T, Ito T, Ishimi Y, Nagasawa H, Matsumoto T, Yanagisawa J, Kato S (Jun 2003). "The chromatin-remodeling complex WINAC targets a nuclear receptor to promoters and is impaired in Williams syndrome". Cell. 113 (7): 905–17. doi:10.1016/s0092-8674(03)00436-7. PMID 12837248.

추가 정보

Ridgway P, Almouzni G (Aug 2000). "CAF-1 and the inheritance of chromatin states: at the crossroads of DNA replication and repair". Journal of Cell Science. 113 (15): 2647–58. doi:10.1242/jcs.113.15.2647. PMID 10893180.
Blouin JL, Duriaux-Sail G, Chen H, Gos A, Morris MA, Rossier C, Antonarakis SE (Apr 1996). "Mapping of the gene for the p60 subunit of the human chromatin assembly factor (CAF1A) to the Down syndrome region of chromosome 21". Genomics. 33 (2): 309–12. doi:10.1006/geno.1996.0199. PMID 8660983.
Verreault A, Kaufman PD, Kobayashi R, Stillman B (Oct 1996). "Nucleosome assembly by a complex of CAF-1 and acetylated histones H3/H4". Cell. 87 (1): 95–104. doi:10.1016/S0092-8674(00)81326-4. PMID 8858152. S2CID 1416453.
Matsumoto-Taniura N, Pirollet F, Monroe R, Gerace L, Westendorf JM (Sep 1996). "Identification of novel M phase phosphoproteins by expression cloning". Molecular Biology of the Cell. 7 (9): 1455–69. doi:10.1091/mbc.7.9.1455. PMC 275994. PMID 8885239.
Marheineke K, Krude T (Jun 1998). "Nucleosome assembly activity and intracellular localization of human CAF-1 changes during the cell division cycle". The Journal of Biological Chemistry. 273 (24): 15279–86. doi:10.1074/jbc.273.24.15279. PMID 9614144.
Martini E, Roche DM, Marheineke K, Verreault A, Almouzni G (Nov 1998). "Recruitment of phosphorylated chromatin assembly factor 1 to chromatin after UV irradiation of human cells". The Journal of Cell Biology. 143 (3): 563–75. doi:10.1083/jcb.143.3.563. PMC 2148138. PMID 9813080.
Hattori M, Fujiyama A, Taylor TD, Watanabe H, Yada T, Park HS, Toyoda A, Ishii K, Totoki Y, Choi DK, Groner Y, Soeda E, Ohki M, Takagi T, Sakaki Y, Taudien S, Blechschmidt K, Polley A, Menzel U, Delabar J, Kumpf K, Lehmann R, Patterson D, Reichwald K, Rump A, Schillhabel M, Schudy A, Zimmermann W, Rosenthal A, Kudoh J, Schibuya K, Kawasaki K, Asakawa S, Shintani A, Sasaki T, Nagamine K, Mitsuyama S, Antonarakis SE, Minoshima S, Shimizu N, Nordsiek G, Hornischer K, Brant P, Scharfe M, Schon O, Desario A, Reichelt J, Kauer G, Blocker H, Ramser J, Beck A, Klages S, Hennig S, Riesselmann L, Dagand E, Haaf T, Wehrmeyer S, Borzym K, Gardiner K, Nizetic D, Francis F, Lehrach H, Reinhardt R, Yaspo ML (May 2000). "The DNA sequence of human chromosome 21". Nature. 405 (6784): 311–9. Bibcode:2000Natur.405..311H. doi:10.1038/35012518. PMID 10830953.
Keller C, Krude T (Nov 2000). "Requirement of Cyclin/Cdk2 and protein phosphatase 1 activity for chromatin assembly factor 1-dependent chromatin assembly during DNA synthesis". The Journal of Biological Chemistry. 275 (45): 35512–21. doi:10.1074/jbc.M003073200. PMID 10938080.
Mello JA, Silljé HH, Roche DM, Kirschner DB, Nigg EA, Almouzni G (Apr 2002). "Human Asf1 and CAF-1 interact and synergize in a repair-coupled nucleosome assembly pathway". EMBO Reports. 3 (4): 329–34. doi:10.1093/embo-reports/kvf068. PMC 1084056. PMID 11897662.
Morel AP, Sentis S, Bianchin C, Le Romancer M, Jonard L, Rostan MC, Rimokh R, Corbo L (Jul 2003). "BTG2 antiproliferative protein interacts with the human CCR4 complex existing in vivo in three cell-cycle-regulated forms". Journal of Cell Science. 116 (Pt 14): 2929–36. doi:10.1242/jcs.00480. PMID 12771185.
Nabatiyan A, Krude T (Apr 2004). "Silencing of chromatin assembly factor 1 in human cells leads to cell death and loss of chromatin assembly during DNA synthesis". Molecular and Cellular Biology. 24 (7): 2853–62. doi:10.1128/MCB.24.7.2853-2862.2004. PMC 371118. PMID 15024074.
Shim KS, Bergelson JM, Furuse M, Ovod V, Krude T, Lubec G (2004). "Reduction of chromatin assembly factor 1 p60 and C21orf2 protein, encoded on chromosome 21, in Down syndrome brain". Advances in Down Syndrome Research. Journal of Neural Transmission. Supplementum. Journal of Neural Transmission Supplement 67. Vol. 67. pp. 117–28. doi:10.1007/978-3-7091-6721-2_10. ISBN 978-3-211-40776-9. PMID 15068244.
Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (Aug 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Lin KT, Lu RM, Tarn WY (Oct 2004). "The WW domain-containing proteins interact with the early spliceosome and participate in pre-mRNA splicing in vivo". Molecular and Cellular Biology. 24 (20): 9176–85. doi:10.1128/MCB.24.20.9176-9185.2004. PMC 517884. PMID 15456888.
Groth A, Ray-Gallet D, Quivy JP, Lukas J, Bartek J, Almouzni G (Jan 2005). "Human Asf1 regulates the flow of S phase histones during replicational stress". Molecular Cell. 17 (2): 301–11. doi:10.1016/j.molcel.2004.12.018. PMID 15664198.

외부 링크

UCSC Genome Browser의 인간 CHAF1B 게놈 위치 및 CHAF1B 유전자 세부 정보 페이지.
UCSC Genome Browser의 인간 MPP7 게놈 위치 및 MPP7 유전자 상세 페이지.

인간 염색체 21번 유전자에 대한 이 기사는 짧은 글이다.위키피디아를 확장함으로써 위키피디아를 도울 수 있습니다.

[refGRCh38Ensembl-1] GRCh38: 앙상블 릴리즈 89: ENSG00000159259 - 앙상블, 2017년 5월

[refGRCm38Ensembl-2] GRCm38: 앙상블 릴리즈 89: ENSMUSG000022945 - 앙상블, 2017년 5월

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7600578-5] Kaufman PD, Kobayashi R, Kessler N, Stillman B (Jun 1995). "The p150 and p60 subunits of chromatin assembly factor I: a molecular link between newly synthesized histones and DNA replication". Cell. 81 (7): 1105–14. doi:10.1016/S0092-8674(05)80015-7. PMID 7600578. S2CID 13502921.

[pmid8792829-6] Katsanis N, Fisher EM (Oct 1996). "The gene encoding the p60 subunit of chromatin assembly factor I (CAF1P60) maps to human chromosome 21q22.2, a region associated with some of the major features of Down syndrome". Human Genetics. 98 (4): 497–9. doi:10.1007/s004390050246. PMID 8792829. S2CID 1206979.

[entrez-7] "Entrez Gene: CHAF1B chromatin assembly factor 1, subunit B (p60)".

[pmid11897662-8] Mello JA, Silljé HH, Roche DM, Kirschner DB, Nigg EA, Almouzni G (Apr 2002). "Human Asf1 and CAF-1 interact and synergize in a repair-coupled nucleosome assembly pathway". EMBO Reports. 3 (4): 329–34. doi:10.1093/embo-reports/kvf068. PMC 1084056. PMID 11897662.

[pmid17353931-9] Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3: 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

[pmid12837248-10] Kitagawa H, Fujiki R, Yoshimura K, Mezaki Y, Uematsu Y, Matsui D, Ogawa S, Unno K, Okubo M, Tokita A, Nakagawa T, Ito T, Ishimi Y, Nagasawa H, Matsumoto T, Yanagisawa J, Kato S (Jun 2003). "The chromatin-remodeling complex WINAC targets a nuclear receptor to promoters and is impaired in Williams syndrome". Cell. 113 (7): 905–17. doi:10.1016/s0092-8674(03)00436-7. PMID 12837248.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

Search

샤프1B

네임스페이스

더

목차

기능.

상호 작용

레퍼런스

추가 정보

외부 링크