호모 사피엔스 종의 단백질 코드 유전자
히스톤 샤페론 ASF1A 는 인간의 ASF1A [5] [6] [7] 단백질 이다.
기능. 이 유전자는 히스톤 샤페론 단백질의 H3/H4 계열의 멤버를 코드하며 효모의 안티실링 기능-1 유전자와 유사하다. 단백질은 뉴클레오솜 조립에서 기능하는 히스톤 공여 복합체의 핵심 성분이다. 히스톤 H3, H4와 상호작용하며 DNA 복제 및 복구 [7]
상호 작용 ASF1A는 TLK1 ,[8] [9] TLK2 ,[8] CHAF1B [10] CHAF1A 와 [10] 것 으로 나타났습니다.
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외부 링크
PDB 갤러리
1tey : 인간 히스톤 샤페론의 NMR 구조, ASF1A
2i32 : 인간 ASF1a-HIRA 콤플렉스의 구조와 히스톤 샤페론 콤플렉스 어셈블리의 특이성에 대한 통찰
2iij : 히스톤 H3와 복합체 인간 Af1a 구조
2io5 : CIA-히스톤 H3-H4 복합체의 결정 구조
