호모 사피엔스 종의 단백질 코드 유전자
히스톤 샤페론 ASF1A 는 인간의 ASF1A [5] [6] [7] 유전자에 의해 암호화되는 단백질 이다.
기능. 이 유전자는 히스톤 샤페론 단백질의 H3/H4 계열의 멤버를 코드하며 효모의 안티실링 기능-1 유전자와 유사하다. 단백질은 뉴클레오솜 조립에서 기능하는 히스톤 공여 복합체의 핵심 성분이다. 히스톤 H3, H4와 상호작용하며 DNA 복제 및 복구 [7] 중에 염색질 조립 인자와 함께 기능합니다.
상호 작용 ASF1A는 TLK1 ,[8] [9] TLK2 ,[8] CHAF1B [10] 및 CHAF1A 와 [10] 상호 작용하는 것 으로 나타났습니다.
레퍼런스 ^ a b c GRCh38: 앙상블 릴리즈 89: ENSG00000111875 - 앙상블 , 2017년 5월 ^ a b c GRCm38: 앙상블 릴리즈 89: ENSMUSG000019857 - 앙상블 , 2017년 5월 ^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine . ^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine . ^ Lai CH, Chou CY, Ch'ang LY, Liu CS, Lin W (May 2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics" . Genome Research . 10 (5): 703–13. doi :10.1101/gr.10.5.703 . PMC 310876 . PMID 10810093 . ^ Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z (Oct 2000). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells" . 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외부 링크
PDB 갤러리
1tey : 인간 히스톤 샤페론의 NMR 구조, ASF1A
2i32 : 인간 ASF1a-HIRA 콤플렉스의 구조와 히스톤 샤페론 콤플렉스 어셈블리의 특이성에 대한 통찰
2iij : 히스톤 H3와 복합체 인간 Af1a 구조
2io5 : CIA-히스톤 H3-H4 복합체의 결정 구조