Bcl-2유사단백질1

Bcl-2-like protein 1
BCL2L1
Protein BCL2L1 PDB 1af3.png
사용 가능한 구조
PDBOrtholog 검색: PDBe RCSB
식별자
에일리어스BCL2L1, Bcl2l1, Bcl(X)L, Bcl-XL, Bcl2l, BclX, bcl-x, bcl2-L-1, BCL-XL/S, BCLXL, BPPR
외부 IDOMIM: 600039 MGI: 88139 HomoloGene: 7639 GeneCard: BCL2L1
맞춤법
종.인간마우스
엔트레즈

598

12048

앙상블

ENSG00000171552

ENSMUSG00000007659

유니프로트

Q07817
Q5TE64

Q64373

RefSeq(mRNA)

NM_001289716
NM_001289717
NM_001289739
NM_009743
NM_001355053

RefSeq(단백질)

NP_001276645
NP_001276646
NP_001276768
NP_033873
NP_001341982

장소(UCSC)Chr 20: 31.66 ~31.72 MbChr 2: 152.62 ~152.67 Mb
PubMed 검색[3][4]
위키데이터
인간 보기/편집마우스 표시/편집

BCL-2 유사단백질 1은 BCL2L1 유전자에 의해 인간에게 코드되는 단백질이다.대체 스플라이싱을 통해 이 유전자는 인간 단백질 Bcl-xL과 Bcl-xS를 [5]모두 암호화한다.

기능.

이 유전자에 의해 암호화된 단백질은 Bcl-2 단백질군에 속합니다.Bcl-2 패밀리는 헤테로 또는 호모디머를 형성하고 광범위한 세포 활동에 관여하는 항아포토시스 조절제 또는 항아포토시스 조절제 역할을 한다.이 유전자에 의해 암호화된 단백질은 미토콘드리아 외막에 위치하고 있으며, 미토콘드리아 외막 채널(전압의존성 음이온 채널(VDACs)) 개방을 조절하는 것으로 나타났다.VDAC는 미토콘드리아 막 전위를 조절하고, 따라서 미토콘드리아에 의한 활성산소의 생성과 시토크롬C의 방출을 통제하며, 두 가지 모두 세포자멸의 잠재적 유도체이다.서로 다른 Isoform을 인코딩하는 두 가지 대체 스플라이스된 전사 변형이 보고되었다.긴 아이소폼(Bcl-xL)은 아포토시스 억제제,[5][6] 짧은 아이소폼(Bcl-xS)은 아포토시스 활성제 역할을 한다.

상호 작용

BCL2와 같은 1(유전자)은 다음과 상호작용하는 것으로 나타났다.

레퍼런스

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