호모 사피엔스 종의 단백질 코드 유전자
아연 손가락과 호메오박스 단백질 1 은 ZHX1 [5] [6] 단백질 이다.
아연 핑거와 호메오박스 유전자 패밀리의 구성원은 핵 인자 Y(NF-YA)의 A 서브유닛과 상호작용하는 핵 동질체 전사 억제제이며, 2개의 C2H2형 아연 핑거와 5개의 호메오박스 DNA 결합 도메인을 포함한다. 이 유전자는 이 유전자군의 구성원 1을 암호화한다. 이 단백질은 호모디머를 형성할 뿐만 아니라 아연 핑거, 호메오박스 계열의 부재 2, 3과 헤테로다이머화한다. 대체 스플라이싱은 동일한 단백질을 [6]
상호 작용 ZHX1은 [5] [7] 상호 작용하는 것 으로 나타났습니다.
레퍼런스 ^ a b c GRCh38: 앙상블 릴리즈 89: ENSG00000165156 - 앙상블 , 2017년 5월^ a b c GRCm38: 앙상블 릴리즈 89: ENSMUSG000022361 - 앙상블 , 2017년 5월^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ a b Yamada K, Printz RL, Osawa H, Granner DK (August 1999). "Human ZHX1: cloning, chromosomal location, and interaction with transcription factor NF-Y" . Biochemical and Biophysical Research Communications . 261 (3): 614–21. doi :10.1006/bbrc.1999.1087 . PMID 10441475 . S2CID 35415109 . ^ a b "Entrez Gene: ZHX1 zinc fingers and homeoboxes 1" .^ Yamada K, Osawa H, Granner DK (October 1999). "Identification of proteins that interact with NF-YA" . FEBS Letters . 460 (1): 41–5. doi :10.1016/S0014-5793(99)01311-3 PMID 10571058 . S2CID 28576187 .
추가 정보 Yamada K, Osawa H, Granner DK (October 1999). "Identification of proteins that interact with NF-YA" . FEBS Letters . 460 (1): 41–5. doi :10.1016/S0014-5793(99)01311-3 PMID 10571058 . S2CID 28576187 . Hirano S, Yamada K, Kawata H, Shou Z, Mizutani T, Yazawa T, et al. (May 2002). "Rat zinc-fingers and homeoboxes 1 (ZHX1), a nuclear factor-YA-interacting nuclear protein, forms a homodimer". Gene . 290 (1–2): 107–14. doi :10.1016/S0378-1119(02)00553-X . PMID 12062805 . Yamada K, Kawata H, Matsuura K, Shou Z, Hirano S, Mizutani T, et al. (September 2002). "Functional analysis and the molecular dissection of zinc-fingers and homeoboxes 1 (ZHX1)". Biochemical and Biophysical Research Communications . 297 (2): 368–74. doi :10.1016/S0006-291X(02)02203-9 . PMID 12237128 . Yamada K, Kawata H, Shou Z, Hirano S, Mizutani T, Yazawa T, et al. (July 2003). "Analysis of zinc-fingers and homeoboxes (ZHX)-1-interacting proteins: molecular cloning and characterization of a member of the ZHX family, ZHX3" . The Biochemical Journal . 373 (Pt 1): 167–78. doi :10.1042/BJ20021866 . PMC 1223464 PMID 12659632 . Kawata H, Yamada K, Shou Z, Mizutani T, Yazawa T, Yoshino M, et al. (August 2003). "Zinc-fingers and homeoboxes (ZHX) 2, a novel member of the ZHX family, functions as a transcriptional repressor" . The Biochemical Journal . 373 (Pt 3): 747–57. doi :10.1042/BJ20030171 . PMC 1223552 PMID 12741956 . Lehner B, Semple JI, Brown SE, Counsell D, Campbell RD, Sanderson CM (January 2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region". Genomics . 83 (1): 153–67. doi :10.1016/S0888-7543(03)00235-0 . PMID 14667819 . Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, et al. (June 2004). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nature Biotechnology . 22 (6): 707–16. doi :10.1038/nbt971 . PMID 15146197 . S2CID 27764390 . Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, et al. (August 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins" . Proceedings of the National Academy of Sciences of the United States of America . 101 (33): 12130–5. Bibcode :2004PNAS..10112130B . doi :10.1073/pnas.0404720101 PMC 514446 PMID 15302935 . Goehler H, Lalowski M, Stelzl U, Waelter S, Stroedicke M, Worm U, et al. (September 2004). "A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease" . Molecular Cell . 15 (6): 853–65. doi :10.1016/j.molcel.2004.09.016 PMID 15383276 . Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, et al. (September 2005). "A human protein-protein interaction network: a resource for annotating the proteome" . Cell . 122 (6): 957–68. doi :10.1016/j.cell.2005.08.029 PMID 16169070 . Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, et al. (May 2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration" . Cell . 125 (4): 801–14. doi :10.1016/j.cell.2006.03.032 PMID 16713569 . Liu G, Clement LC, Kanwar YS, Avila-Casado C, Chugh SS (December 2006). "ZHX proteins regulate podocyte gene expression during the development of nephrotic syndrome" . The Journal of Biological Chemistry . 281 (51): 39681–92. doi :10.1074/jbc.M606664200 PMID 17056598 . Kim SH, Park J, Choi MC, Kim HP, Park JH, Jung Y, et al. (April 2007). "Zinc-fingers and homeoboxes 1 (ZHX1) binds DNA methyltransferase (DNMT) 3B to enhance DNMT3B-mediated transcriptional repression". Biochemical and Biophysical Research Communications . 355 (2): 318–23. doi :10.1016/j.bbrc.2007.01.187 . PMID 17303076 . 외부 링크
PDB 갤러리
2ecb : 인간 아연 손가락과 호메오박스 단백질의 세 번째 호메오박스 영역의 용액 구조
2ghf : 인간 아연 핑거 및 호메오박스 1(ZHX1)의 전체 아연 핑거 영역의 용액 구조
