아연핑거 FYVE 도메인 함유 단백질 16 은 ZFYVE16 [5] [6] 유전자 에 의해 인체 내에서 부호화되는 단백질 이다.
ZFYVE16 유전자는 막트래픽 조절에 관여하는 내염색체 단백질인 엔도핀을 암호화한다. 포스파티딜이노시톨 3-인산결합 FYVE 도메인이 분자 중앙에 위치하는 것이 특징이다(Seet 등, 2004). [OMIM [6]
멜라노사이트 세포에서 ZFYVE16 유전자 발현은 MITF에 [7] 의해 조절될 수 있다.
상호 작용 ZFYVE16은 TOM1 과 [8] 것 으로 나타났습니다.
레퍼런스 ^ a b c GRCh38: 앙상블 릴리즈 89: ENSG000039319 - 앙상블 , 2017년 5월^ a b c GRCm38: 앙상블 릴리즈 89: ENSMUSG000021706 - 앙상블 , 2017년 5월^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Seet LF, Hong W (November 2001). "Endofin, an endosomal FYVE domain protein" . The Journal of Biological Chemistry . 276 (45): 42445–54. doi :10.1074/jbc.M105917200 PMID 11546807 . ^ a b "Entrez Gene: ZFYVE16 zinc finger, FYVE domain containing 16" .^ Hoek KS, Schlegel NC, Eichhoff OM, Widmer DS, Praetorius C, Einarsson SO, et al. (December 2008). "Novel MITF targets identified using a two-step DNA microarray strategy" . Pigment Cell & Melanoma Research . 21 (6): 665–76. doi :10.1111/j.1755-148X.2008.00505.x PMID 19067971 . S2CID 24698373 . ^ Seet LF, Liu N, Hanson BJ, Hong W (February 2004). "Endofin recruits TOM1 to endosomes" . The Journal of Biological Chemistry . 279 (6): 4670–9. doi :10.1074/jbc.M311228200 PMID 14613930 .
추가 정보 Nagase T, Ishikawa K, Nakajima D, Ohira M, Seki N, Miyajima N, et al. (April 1997). "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro" . DNA Research . 4 (2): 141–50. doi :10.1093/dnares/4.2.141 PMID 9205841 . Seet LF, Liu N, Hanson BJ, Hong W (February 2004). "Endofin recruits TOM1 to endosomes" . The Journal of Biological Chemistry . 279 (6): 4670–9. doi :10.1074/jbc.M311228200 PMID 14613930 . Brill LM, Salomon AR, Ficarro SB, Mukherji M, Stettler-Gill M, Peters EC (May 2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry". Analytical Chemistry . 76 (10): 2763–72. doi :10.1021/ac035352d . PMID 15144186 . Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, et al. (July 2004). "Functional proteomics mapping of a human signaling pathway" . Genome Research . 14 (7): 1324–32. doi :10.1101/gr.2334104 . PMC 442148 PMID 15231748 . Rush J, Moritz A, Lee KA, Guo A, Goss VL, Spek EJ, et al. (January 2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nature Biotechnology . 23 (1): 94–101. doi :10.1038/nbt1046 . PMID 15592455 . S2CID 7200157 . Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, et al. (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature . 437 (7062): 1173–8. Bibcode :2005Natur.437.1173R . doi :10.1038/nature04209 . PMID 16189514 . S2CID 4427026 . Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, et al. (January 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes" . Genome Research . 16 (1): 55–65. doi :10.1101/gr.4039406 . PMC 1356129 PMID 16344560 . Zhao BM, Hoffmann FM (September 2006). "Inhibition of transforming growth factor-beta1-induced signaling and epithelial-to-mesenchymal transition by the Smad-binding peptide aptamer Trx-SARA" . Molecular Biology of the Cell . 17 (9): 3819–31. doi :10.1091/mbc.E05-10-0990 . PMC 1556379 PMID 16775010 . Chen YG, Wang Z, Ma J, Zhang L, Lu Z (March 2007). "Endofin, a FYVE domain protein, interacts with Smad4 and facilitates transforming growth factor-beta signaling" . The Journal of Biological Chemistry . 282 (13): 9688–95. doi :10.1074/jbc.M611704200 PMID 17272273 . Chen Y, Low TY, Choong LY, Ray RS, Tan YL, Toy W, et al. (July 2007). "Phosphoproteomics identified Endofin, DCBLD2, and KIAA0582 as novel tyrosine phosphorylation targets of EGF signaling and Iressa in human cancer cells". Proteomics . 7 (14): 2384–97. doi :10.1002/pmic.200600968 . PMID 17570516 . S2CID 23944956 .
