UHRF1

UHRF1
사용 가능한 구조
PDB	Ortholog 검색: PDBe RCSB
PDB ID 코드 목록
	2FAZ, 2LG, 2LGK, 2LGL, 2PB7, 3ASK, 3ASK, 3ASL, 3BI7, 3CLZ, 3DB3, 3DB4, 3DWH, 3FL2, 3SHB, 3SOU, 3SOW, 3SOW, 3SOW
식별자
에일리어스	UHRF1, ICBP90, Np95, RNF106, hNP95, hhuNp95, TDRD22, 유비퀴틴 유사 PHD 및 약지 도메인 1
외부 ID	OMIM: 607990 MGI: 1338889 HomoloGene: 7866 GenCard: UHRF1
유전자 위치(인간)
크르.	19번 염색체(인간)
끝.	4,962,196 bp
유전자 위치(마우스)
크르.	17번 염색체(쥐)
끝.	56,630,486 bp
RNA발현패턴
	상단 표시 위치:
	난모세포; ; 이차 난모세포; ; 흉선; ; 신경절 융기; ; 결석골; ; 골수; ; 자궁내막간질세포; ; 골수 세포; ; 부록; ; 림프절;
	추가 참조 표현식 데이터
	추가 참조 표현식 데이터
유전자 존재론
분자 함수	DNA결합; GO:1904264, GO:1904822, GO:0090622, GO:0090302 유비퀴틴단백질리가수분해효소활성; 헤미메틸화DNA결합; GO:0001131, GO:000115, GO:0001130, GO:0001204 DNA결합전사인자액티비티; 메틸-CpG 결합; GO:0001158 cis-조절영역 배열 특이 DNA 결합; 금속 이온 결합; 유비퀴틴산전달효소활성; 뉴클레오좀히스톤결합; 메틸화히스톤결합; GO:0001948 단백질 결합; 동일단백질결합; 트랜스페라아제 활성; 아연 이온 결합; 히스톤 결합;
셀룰러 컴포넌트	에크로마틴; 핵매트릭스; 레플리케이션 포크; 헤테로크로마틴; 핵;
생물학적 과정	히스톤 모노우비퀴트화; 세포단백질대사과정양성조절; 전사조절, DNA템플릿화; DNA메틸화유지; DNA토포이소머라아제(ATP 가수분해효소) 활성의 양성 조절; RNA중합효소II에 의한 전사 음성 조절; 전사, DNA 템플릿; DNA메틸화의존성 헤테로크로마틴조립체조절; DNA 손상 자극에 대한 세포 반응; 단백질유비퀴티네이션; 세포 주기; 세포군 증식; 히스톤 유비쿼티네이션; DNA복구; RNA중합효소II에 의한 전사의 양성 조절; 단백질 자기염화; 크로마틴 조직; 유비퀴틴의존성 단백질 이화 과정; 상피세포증식조절;
	출처:아미고 / QuickGO
맞춤법
	29128
	18140
	ENSG00000276043
	ENSMUSG00000001228
	Q96T88
	Q8 VDF2
	NM_001048201; NM_001290050; NM_001290051; NM_001290052; NM_013282
	NM_001111078; NM_001111079; NM_001111080; NM_010931
	NP_001041666; NP_001276979; NP_001276980; NP_001276981; NP_037414
	NP_001104548; NP_001104549; NP_001104550; NP_035061
	위키데이터
인간 보기/편집	마우스 표시/편집

PHD 및 RING 핑거 도메인을 포함하는 유비퀴틴 유사체, 1은 UHRF1 ^[5]^[6]유전자에 의해 인체에서 암호화되는 단백질이다.

기능.

이 유전자는 RING-핑거형 E3 유비퀴틴 연결효소의 하위 계열의 구성원을 암호화합니다.이 단백질은 S상 동안 헤미메틸화 DNA에 결합하고 주요 DNA 메틸전달효소 단백질인 DNMT1을 분비하여 염색질 구조와 유전자 발현을 조절한다.그 표현은 후기의 G1 단계에서 최고점에 달하며 셀 사이클의 G2 및 M 단계에서 계속됩니다.G1/S 전이에서 중요한 역할을 하며 p53 의존성 DNA 손상 검사점에서 기능합니다.이 유전자에 대해 서로 다른 아이소폼을 코드하는 여러 개의 전사 변형이 발견되었다.이는 원래 토포이소머라아제 2a의 직접 조절제로 확인되었지만, 이후 반증되었다.Uhrf1은 제브라피쉬를 사용하여 생체 내에서 광범위하게 연구되어 왔다.

임상적 의의

UHRF1은 최근 간암의 ^[7]주요 유형인 간세포암에서 새로운 종양 유전자로 확인되었다.

레퍼런스

^ ^a ^b ^c GRCh38: 앙상블 릴리즈 89: ENSG00000276043 - 앙상블, 2017년 5월
^ ^a ^b ^c GRCm38: 앙상블 릴리즈 89: ENSMUSG00000001228 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: UHRF1 ubiquitin-like, containing PHD and RING finger domains, 1".
^ Hopfner R, Mousli M, Jeltsch JM, Voulgaris A, Lutz Y, Marin C, Bellocq JP, Oudet P, Bronner C (Jan 2000). "ICBP90, a novel human CCAAT binding protein, involved in the regulation of topoisomerase IIalpha expression". Cancer Research. 60 (1): 121–8. PMID 10646863.
^ Mudbhary, Raksha; Hoshida, Yujin; Chernyavskaya, Yelena; Jacob, Vinitha; Villanueva, Augusto; Fiel, M. Isabel; Chen, Xintong; Kojima, Kensuke; Thung, Swan; Bronson, Roderick T.; Lachenmayer, Anja; Revill, Kate; Alsinet, Clara; Sachidanandam, Ravi; Desai, Anal; Senbanerjee, Sucharita; Ukomadu, Chinweike; Llovet, Josep M.; Sadler, Kirsten C. (2014). "UHRF1 Overexpression Drives DNA Hypomethylation and Hepatocellular Carcinoma". Cancer Cell. 25 (2): 196–209. doi:10.1016/j.ccr.2014.01.003. PMC 3951208. PMID 24486181.

추가 정보

Ku DH, Chang CD, Koniecki J, Cannizzaro LA, Boghosian-Sell L, Alder H, Baserga R (Apr 1991). "A new growth-regulated complementary DNA with the sequence of a putative trans-activating factor". Cell Growth & Differentiation. 2 (4): 179–86. PMID 1868030.
Hillier LD, Lennon G, Becker M, Bonaldo MF, Chiapelli B, Chissoe S, Dietrich N, DuBuque T, Favello A, Gish W, Hawkins M, Hultman M, Kucaba T, Lacy M, Le M, Le N, Mardis E, Moore B, Morris M, Parsons J, Prange C, Rifkin L, Rohlfing T, Schellenberg K, Bento Soares M, Tan F, Thierry-Meg J, Trevaskis E, Underwood K, Wohldman P, Waterston R, Wilson R, Marra M (September 1996). "Generation and analysis of 280,000 human expressed sequence tags". Genome Research. 6 (9): 807–28. doi:10.1101/gr.6.9.807. PMID 8889549.
Hopfner R, Mousli M, Jeltsch JM, Voulgaris A, Lutz Y, Marin C, Bellocq JP, Oudet P, Bronner C (Jan 2000). "ICBP90, a novel human CCAAT binding protein, involved in the regulation of topoisomerase IIalpha expression". Cancer Research. 60 (1): 121–8. PMID 10646863.
Hopfner R, Mousli M, Garnier JM, Redon R, du Manoir S, Chatton B, Ghyselinck N, Oudet P, Bronner C (Mar 2001). "Genomic structure and chromosomal mapping of the gene coding for ICBP90, a protein involved in the regulation of the topoisomerase IIalpha gene expression". Gene. 266 (1–2): 15–23. doi:10.1016/S0378-1119(01)00371-7. PMID 11290415.
Mousli M, Hopfner R, Abbady AQ, Monté D, Jeanblanc M, Oudet P, Louis B, Bronner C (Jul 2003). "ICBP90 belongs to a new family of proteins with an expression that is deregulated in cancer cells". British Journal of Cancer. 89 (1): 120–7. doi:10.1038/sj.bjc.6601068. PMC 2394215. PMID 12838312.
Citterio E, Papait R, Nicassio F, Vecchi M, Gomiero P, Mantovani R, Di Fiore PP, Bonapace IM (Mar 2004). "Np95 is a histone-binding protein endowed with ubiquitin ligase activity". Molecular and Cellular Biology. 24 (6): 2526–35. doi:10.1128/MCB.24.6.2526-2535.2004. PMC 355858. PMID 14993289.
Arima Y, Hirota T, Bronner C, Mousli M, Fujiwara T, Niwa S, Ishikawa H, Saya H (Feb 2004). "Down-regulation of nuclear protein ICBP90 by p53/p21Cip1/WAF1-dependent DNA-damage checkpoint signals contributes to cell cycle arrest at G1/S transition". Genes to Cells. 9 (2): 131–42. doi:10.1111/j.1356-9597.2004.00710.x. PMID 15009091. S2CID 23980129.
Abbady AQ, Bronner C, Trotzier MA, Hopfner R, Bathami K, Muller CD, Jeanblanc M, Mousli M (December 2003). "ICBP90 expression is downregulated in apoptosis-induced Jurkat cells". Annals of the New York Academy of Sciences. 1010: 300–3. doi:10.1196/annals.1299.052. PMID 15033738. S2CID 32581931.
Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW (June 2004). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nature Biotechnology. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
Trotzier MA, Bronner C, Bathami K, Mathieu E, Abbady AQ, Jeanblanc M, Muller CD, Rochette-Egly C, Mousli M (June 2004). "Phosphorylation of ICBP90 by protein kinase A enhances topoisomerase IIalpha expression". Biochemical and Biophysical Research Communications. 319 (2): 590–5. doi:10.1016/j.bbrc.2004.05.028. PMID 15178447.
Unoki M, Nishidate T, Nakamura Y (Oct 2004). "ICBP90, an E2F-1 target, recruits HDAC1 and binds to methyl-CpG through its SRA domain". Oncogene. 23 (46): 7601–10. doi:10.1038/sj.onc.1208053. PMID 15361834.
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Jenkins Y, Markovtsov V, Lang W, Sharma P, Pearsall D, Warner J, Franci C, Huang B, Huang J, Yam GC, Vistan JP, Pali E, Vialard J, Janicot M, Lorens JB, Payan DG, Hitoshi Y (December 2005). "Critical role of the ubiquitin ligase activity of UHRF1, a nuclear RING finger protein, in tumor cell growth". Molecular Biology of the Cell. 16 (12): 5621–9. doi:10.1091/mbc.E05-03-0194. PMC 1289407. PMID 16195352.
Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (Jan 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
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이 단백질 관련 기사는 스텁입니다.위키피디아를 확장함으로써 위키피디아를 도울 수 있습니다.

[refGRCh38Ensembl-1] GRCh38: 앙상블 릴리즈 89: ENSG00000276043 - 앙상블, 2017년 5월

[refGRCm38Ensembl-2] GRCm38: 앙상블 릴리즈 89: ENSMUSG00000001228 - 앙상블, 2017년 5월

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: UHRF1 ubiquitin-like, containing PHD and RING finger domains, 1".

[pmid10646863-6] Hopfner R, Mousli M, Jeltsch JM, Voulgaris A, Lutz Y, Marin C, Bellocq JP, Oudet P, Bronner C (Jan 2000). "ICBP90, a novel human CCAAT binding protein, involved in the regulation of topoisomerase IIalpha expression". Cancer Research. 60 (1): 121–8. PMID 10646863.

[7] Mudbhary, Raksha; Hoshida, Yujin; Chernyavskaya, Yelena; Jacob, Vinitha; Villanueva, Augusto; Fiel, M. Isabel; Chen, Xintong; Kojima, Kensuke; Thung, Swan; Bronson, Roderick T.; Lachenmayer, Anja; Revill, Kate; Alsinet, Clara; Sachidanandam, Ravi; Desai, Anal; Senbanerjee, Sucharita; Ukomadu, Chinweike; Llovet, Josep M.; Sadler, Kirsten C. (2014). "UHRF1 Overexpression Drives DNA Hypomethylation and Hepatocellular Carcinoma". Cancer Cell. 25 (2): 196–209. doi:10.1016/j.ccr.2014.01.003. PMC 3951208. PMID 24486181.

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UHRF1

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목차

기능.

임상적 의의

레퍼런스

추가 정보