호모사피엔스 종의 단백질 코딩 유전자
TAB1 사용 가능한 구조물 PDB 직교 검색: PDBe RCSB PDB ID 코드 목록 2J4O , 2POM, 2POP , 2YDS , 2YY , 4AY5 , 4AY6 , 4GS6 , 4KA3 , 4L3P , 4L53 , 4O91 , 5DIY , 5JGA , 5JGD
식별자 별칭 Tab1 IP1, TGF-베타활성키나제1/MAP3K7결합단백질1, TGF-베타활성키나제1(MAP3K7)결합단백질1 외부 ID OMIM : 602615 MGI : 1913763 호몰로진 : 4461 GeneCard : TAB1 직교체 종 인간 마우스 엔트레스 앙상블 유니프로트 RefSeq(mRNA) RefSeq(단백질) 위치(UCSC) Cr 22: 39.4 – 39.44Mb Chr 15: 80.02 – 80.05Mb PubMed 검색[3] [4] 위키다타
미토겐 활성 단백질 키나아제 키나제 7 상호작용 단백질 1 은 인간에서 TAB1 유전자 에 의해 암호화된 효소 다.[5] [6] [7]
함수 이 유전자가 인코딩한 단백질은 TGF-베타 , 인터루킨-1 , WNT-1 등 다양한 세포내 신호 경로 를 매개하는 것으로 알려진 MAP 키나제 키나제 MAP3K7/TAK1의 조절기로 확인되었다. 이 단백질은 상호 작용하여 TAC1 키나제를 활성화시킨다. 이 단백질의 C-단자 부분은 TAK1의 결합과 활성화에 충분한 반면, N-단자 일부는 TGF 베타 수용체와 TAK1 사이에서 이 단백질이 중재자 역할을 할 수 있음을 시사한다. 이 단백질은 또한 미토겐 활성 단백질 키나아제 14 (MAPK14/p38알파)와 상호 작용하여 활성화할 수 있으므로 MAPKK 경로 외에 대체 활성화 경로를 나타내 다양한 자극에 대한 MAPK14의 생물학적 반응에 기여한다. 또는 구별되는 ISO 양식을 인코딩하는 분할된 대본 변형이 보고되었다.[7] TAB1에는 인산화 및 유비쿼터스 처리된 여러 아미노산 부위가 포함되어 있다.[8]
이 단백질은 피부 동종 , 상처 회복,[9] [10] [11] [12] 그리고 종양 발생에 중요한 역할을 한다.[13]
상호작용 TAB1은 다음과 상호 작용하는 것으로 나타났다.
참조 ^ a b c GRCh38: 앙상블 릴리스 89: ENSG00000100324 - 앙상블 , 2017년 5월^ a b c GRCm38: 앙상블 릴리스 89: ENSMUSG000022414 - 앙상블 , 2017년 5월^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Shibuya H, Yamaguchi K, Shirakabe K, Tonegawa A, Gotoh Y, Ueno N, Irie K, Nishida E, Matsumoto K (July 1996). "TAB1: an activator of the TAK1 MAPKKK in TGF-beta signal transduction". Science . 272 (5265): 1179–82. Bibcode :1996Sci...272.1179S . doi :10.1126/science.272.5265.1179 . PMID 8638164 . S2CID 84807994 . ^ Sakurai H, Miyoshi H, Toriumi W, Sugita T (May 1999). "Functional interactions of transforming growth factor beta-activated kinase 1 with IkappaB kinases to stimulate NF-kappaB activation" . J Biol Chem . 274 (15): 10641–8. doi :10.1074/jbc.274.15.10641 PMID 10187861 . ^ a b "Entrez Gene: MAP3K7IP1 mitogen-activated protein kinase kinase kinase 7 interacting protein 1" .^ "TAB1 (human)" . www.phosphosite.org . Retrieved 2020-10-31 .^ Omori E, Matsumoto K, Sanjo H, Sato S, Akira S, Smart RC, Ninomiya-Tsuji J (July 2006). "TAK1 is a master regulator of epidermal homeostasis involving skin inflammation and apoptosis" . J. Biol. Chem . 281 (28): 19610–19617. doi :10.1074/jbc.M603384200 PMC 1797070 PMID 16675448 . ^ Sayama K, Hanakawa Y, Nagai H, Shirakata Y, Dai X, Hirakawa S, Tokumaru S, Tohyama M, Yang L, Sato S, Shizuo A, Hashimoto K (August 2006). "Transforming growth factor-beta-activated kinase 1 is essential for differentiation and the prevention of apoptosis in epidermis" . J. Biol. Chem . 281 (31): 22013–22020. doi :10.1074/jbc.M601065200 PMID 16754690 . ^ Tan SH, Pal M, Tan MJ, Wong MH, Tam FU, Teo JW, Chong HC, Tan CK, Goh YY, Tang MB, Cheung PC, Tan NS (July 2009). "Regulation of cell proliferation and migration by TAK1 via transcriptional control of von Hippel-Lindau tumor suppressor" . J. Biol. Chem . 284 (27): 18047–18058. doi :10.1074/jbc.M109.002691 PMC 2709347 PMID 19419968 . ^ Lam CR, Tan MJ, Tan SH, Tang MB, Cheung PC, Tan NS (January 2011). "TAK1 regulates SCF expression to modulate PKBα activity that protects keratinocytes from ROS-induced apoptosis" . Cell Death Differ . 18 (7): 1120–9. doi :10.1038/cdd.2010.182 . PMC 3131962 PMID 21233843 . ^ Omori E, Matsumoto K, Zhu S, Smart RC, Ninomiya-Tsuji J (November 2010). "Ablation of TAK1 upregulates reactive oxygen species and selectively kills tumor cells" . Cancer Res . 70 (21): 8417–8425. doi :10.1158/0008-5472.CAN-10-1227 . PMC 2970664 PMID 20959492 . ^ a b Takaesu G, Kishida S, Hiyama A, Yamaguchi K, Shibuya H, Irie K, Ninomiya-Tsuji J, Matsumoto K (April 2000). "TAB2, a novel adaptor protein, mediates activation of TAK1 MAPKKK by linking TAK1 to TRAF6 in the IL-1 signal transduction pathway" . Mol. Cell . 5 (4): 649–58. doi :10.1016/s1097-2765(00)80244-0 PMID 10882101 . ^ Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, Cruciat C, Eberhard D, Gagneur J, Ghidelli S, Hopf C, Huhse B, Mangano R, Michon AM, Schirle M, Schlegl J, Schwab M, Stein MA, Bauer A, Casari G, Drewes G, Gavin AC, Jackson DB, Joberty G, Neubauer G, Rick J, Kuster B, Superti-Furga G (February 2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol . 6 (2): 97–105. doi :10.1038/ncb1086 . PMID 14743216 . S2CID 11683986 . ^ a b c Cheung PC, Nebreda AR, Cohen P (February 2004). "TAB3, a new binding partner of the protein kinase TAK1" . Biochem. J . 378 (Pt 1): 27–34. doi :10.1042/BJ20031794 . PMC 1223947 PMID 14670075 . ^ a b Ninomiya-Tsuji J, Kishimoto K, Hiyama A, Inoue J, Cao Z, Matsumoto K (March 1999). "The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway". Nature . 398 (6724): 252–6. Bibcode :1999Natur.398..252N . doi :10.1038/18465 . PMID 10094049 . S2CID 4421236 . ^ Channavajhala PL, Wu L, Cuozzo JW, Hall JP, Liu W, Lin LL, Zhang Y (November 2003). "Identification of a novel human kinase supporter of Ras (hKSR-2) that functions as a negative regulator of Cot (Tpl2) signaling" . J. Biol. Chem . 278 (47): 47089–97. doi :10.1074/jbc.M306002200 PMID 12975377 . ^ Sakurai H, Miyoshi H, Mizukami J, Sugita T (June 2000). "Phosphorylation-dependent activation of TAK1 mitogen-activated protein kinase kinase kinase by TAB1" . FEBS Lett . 474 (2–3): 141–5. doi :10.1016/s0014-5793(00)01588-x PMID 10838074 . ^ Charlaftis N, Suddason T, Wu X, Anwar S, Karin M, Gallagher E (November 2014). "The MEKK1 PHD ubiquitinates TAB1 to activate MAPKs in response to cytokines" . The EMBO Journal . 33 (21): 2581–96. doi :10.15252/embj.201488351 . PMC 4282369 PMID 25260751 . ^ Ge B, Gram H, Di Padova F, Huang B, New L, Ulevitch RJ, Luo Y, Han J (February 2002). "MAPKK-independent activation of p38alpha mediated by TAB1-dependent autophosphorylation of p38alpha". Science . 295 (5558): 1291–4. Bibcode :2002Sci...295.1291G . doi :10.1126/science.1067289 . PMID 11847341 . S2CID 93896233 . ^ Edlund S, Bu S, Schuster N, Aspenström P, Heuchel R, Heldin NE, ten Dijke P, Heldin CH, Landström M (February 2003). "Transforming growth factor-beta1 (TGF-beta)-induced apoptosis of prostate cancer cells involves Smad7-dependent activation of p38 by TGF-beta-activated kinase 1 and mitogen-activated protein kinase kinase 3" . Mol. Biol. Cell . 14 (2): 529–44. doi :10.1091/mbc.02-03-0037 . PMC 149990 PMID 12589052 . ^ Yanagisawa M, Nakashima K, Takeda K, Ochiai W, Takizawa T, Ueno M, Takizawa M, Shibuya H, Taga T (December 2001). "Inhibition of BMP2-induced, TAK1 kinase-mediated neurite outgrowth by Smad6 and Smad7" . Genes Cells . 6 (12): 1091–9. doi :10.1046/j.1365-2443.2001.00483.x PMID 11737269 . ^ Walsh MC, Kim GK, Maurizio PL, Molnar EE, Choi Y (2008). Unutmaz D (ed.). "TRAF6 autoubiquitination-independent activation of the NFkappaB and MAPK pathways in response to IL-1 and RANKL" . PLOS ONE . 3 (12): e4064. Bibcode :2008PLoSO...3.4064W . doi :10.1371/journal.pone.0004064 PMC 2603309 PMID 19112497 . ^ Yamaguchi K, Nagai S, Ninomiya-Tsuji J, Nishita M, Tamai K, Irie K, Ueno N, Nishida E, Shibuya H, Matsumoto K (January 1999). "XIAP, a cellular member of the inhibitor of apoptosis protein family, links the receptors to TAB1-TAK1 in the BMP signaling pathway" . EMBO J . 18 (1): 179–87. doi :10.1093/emboj/18.1.179 . PMC 1171113 PMID 9878061 . ^ Sanna MG, da Silva Correia J, Luo Y, Chuang B, Paulson LM, Nguyen B, Deveraux QL, Ulevitch RJ (August 2002). "ILPIP, a novel anti-apoptotic protein that enhances XIAP-mediated activation of JNK1 and protection against apoptosis" . J. Biol. Chem . 277 (34): 30454–62. doi :10.1074/jbc.M203312200 PMID 12048196 . ^ Kurozumi K, Nishita M, Yamaguchi K, Fujita T, Ueno N, Shibuya H (April 1998). "BRAM1, a BMP receptor-associated molecule involved in BMP signalling". Genes Cells . 3 (4): 257–64. doi :10.1046/j.1365-2443.1998.00186.x . PMID 9663660 . S2CID 29818690 . 추가 읽기 Kurozumi K, Nishita M, Yamaguchi K, Fujita T, Ueno N, Shibuya H (1998). "BRAM1, a BMP receptor-associated molecule involved in BMP signalling". Genes Cells . 3 (4): 257–64. doi :10.1046/j.1365-2443.1998.00186.x . PMID 9663660 . S2CID 29818690 . Yamaguchi K, Nagai S, Ninomiya-Tsuji J, Nishita M, Tamai K, Irie K, Ueno N, Nishida E, Shibuya H, Matsumoto K (1999). "XIAP, a cellular member of the inhibitor of apoptosis protein family, links the receptors to TAB1-TAK1 in the BMP signaling pathway" . EMBO J . 18 (1): 179–87. doi :10.1093/emboj/18.1.179 . PMC 1171113 PMID 9878061 . Ninomiya-Tsuji J, Kishimoto K, Hiyama A, Inoue J, Cao Z, Matsumoto K (1999). "The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway". Nature . 398 (6724): 252–6. Bibcode :1999Natur.398..252N . doi :10.1038/18465 . PMID 10094049 . S2CID 4421236 . Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP (1999). "The DNA sequence of human chromosome 22" . Nature . 402 (6761): 489–95. Bibcode :1999Natur.402..489D . doi :10.1038/990031 PMID 10591208 . Kishimoto K, Matsumoto K, Ninomiya-Tsuji J (2000). "TAK1 mitogen-activated protein kinase kinase kinase is activated by autophosphorylation within its activation loop" . J. Biol. Chem . 275 (10): 7359–64. doi :10.1074/jbc.275.10.7359 PMID 10702308 . Sakurai H, Miyoshi H, Mizukami J, Sugita T (2000). "Phosphorylation-dependent activation of TAK1 mitogen-activated protein kinase kinase kinase by TAB1" . FEBS Lett . 474 (2–3): 141–5. doi :10.1016/S0014-5793(00)01588-X PMID 10838074 . Ono K, Ohtomo T, Sato S, Sugamata Y, Suzuki M, Hisamoto N, Ninomiya-Tsuji J, Tsuchiya M, Matsumoto K (2001). "An evolutionarily conserved motif in the TAB1 C-terminal region is necessary for interaction with and activation of TAK1 MAPKKK" . J. Biol. Chem . 276 (26): 24396–400. doi :10.1074/jbc.M102631200 PMID 11323434 . Qian Y, Commane M, Ninomiya-Tsuji J, Matsumoto K, Li X (2001). "IRAK-mediated translocation of TRAF6 and TAB2 in the interleukin-1-induced activation of NFkappa B." J. Biol. Chem . 276 (45): 41661–7. doi :10.1074/jbc.M102262200 PMID 11518704 . Yanagisawa M, Nakashima K, Takeda K, Ochiai W, Takizawa T, Ueno M, Takizawa M, Shibuya H, Taga T (2002). "Inhibition of BMP2-induced, TAK1 kinase-mediated neurite outgrowth by Smad6 and Smad7" . Genes Cells . 6 (12): 1091–9. doi :10.1046/j.1365-2443.2001.00483.x PMID 11737269 . Ge B, Gram H, Di Padova F, Huang B, New L, Ulevitch RJ, Luo Y, Han J (2002). "MAPKK-independent activation of p38alpha mediated by TAB1-dependent autophosphorylation of p38alpha". Science . 295 (5558): 1291–4. Bibcode :2002Sci...295.1291G . doi :10.1126/science.1067289 . PMID 11847341 . S2CID 93896233 . Sakurai H, Nishi A, Sato N, Mizukami J, Miyoshi H, Sugita T (2002). "TAK1-TAB1 fusion protein: a novel constitutively active mitogen-activated protein kinase kinase kinase that stimulates AP-1 and NF-kappaB signaling pathways". Biochem. Biophys. Res. Commun . 297 (5): 1277–81. doi :10.1016/S0006-291X(02)02379-3 . PMID 12372426 . Ge B, Xiong X, Jing Q, Mosley JL, Filose A, Bian D, Huang S, Han J (2003). "TAB1beta (transforming growth factor-beta-activated protein kinase 1-binding protein 1beta ), a novel splicing variant of TAB1 that interacts with p38alpha but not TAK1" . J. Biol. Chem . 278 (4): 2286–93. doi :10.1074/jbc.M210918200 PMID 12429732 . Ishitani T, Kishida S, Hyodo-Miura J, Ueno N, Yasuda J, Waterman M, Shibuya H, Moon RT, Ninomiya-Tsuji J, Matsumoto K (2003). "The TAK1-NLK mitogen-activated protein kinase cascade functions in the Wnt-5a/Ca(2+) pathway to antagonize Wnt/beta-catenin signaling" . Mol. Cell. Biol . 23 (1): 131–9. doi :10.1128/MCB.23.1.131-139.2003 . PMC 140665 PMID 12482967 . Suzawa M, Takada I, Yanagisawa J, Ohtake F, Ogawa S, Yamauchi T, Kadowaki T, Takeuchi Y, Shibuya H, Gotoh Y, Matsumoto K, Kato S (2003). "Cytokines suppress adipogenesis and PPAR-gamma function through the TAK1/TAB1/NIK cascade". Nat. Cell Biol . 5 (3): 224–30. doi :10.1038/ncb942 . PMID 12598905 . S2CID 114603 . Tanno M, Bassi R, Gorog DA, Saurin AT, Jiang J, Heads RJ, Martin JL, Davis RJ, Flavell RA, Marber MS (2003). "Diverse mechanisms of myocardial p38 mitogen-activated protein kinase activation: evidence for MKK-independent activation by a TAB1-associated mechanism contributing to injury during myocardial ischemia" . Circ. Res . 93 (3): 254–61. doi :10.1161/01.RES.0000083490.43943.85 PMID 12829618 . Channavajhala PL, Wu L, Cuozzo JW, Hall JP, Liu W, Lin LL, Zhang Y (2004). "Identification of a novel human kinase supporter of Ras (hKSR-2) that functions as a negative regulator of Cot (Tpl2) signaling" . J. Biol. Chem . 278 (47): 47089–97. doi :10.1074/jbc.M306002200 PMID 12975377 . Cheung PC, Nebreda AR, Cohen P (2004). "TAB3, a new binding partner of the protein kinase TAK1" . Biochem. J . 378 (Pt 1): 27–34. doi :10.1042/BJ20031794 . PMC 1223947 PMID 14670075 .
