SOAT1
SOAT1| SOAT1 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| 에일리어스 | SOAT1, ACACT, ACAT-1, ACAT1, SOAT, STAT, 스테롤O-아실전달효소1 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| 외부 ID | OMIM: 102642 MGI: 104665 HomoloGene: 2333 GenCard: SOAT1 | ||||||||||||||||||||||||||||||||||||||||||||||||||
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스테롤 O-acyl transferase(acyl-Coenzyme A: 콜레스테롤 아실 transferase) 1은 SOAT1 [5]유전자에 의해 인체에서 코드되는 효소이다.
기능.
아실-코엔자임 A:콜레스테롤 아실전달효소(EC 2.3.1.26)는 콜레스테롤로부터 콜레스테롤 에스테르를 형성하는 세포내 단백질이다.대식세포와 평활근 세포 내에서 세포질 지질 방울로서의 콜레스테롤 에스테르 축적은 아테롬성 동맥경화 플라크의 초기 단계의 특징이다(Cadigan 등, 1988).[5]
구조와 생물 생성
SOAT1은 막결합 O-acyl transferase(MBOAT) 슈퍼패밀리에 속하는 다발성 일체막 단백질이다.SOAT1의 구조는 아직 해결되지 않았지만 세균성 MBOAT인 DltB의 구조는 다중 막 통과 도메인(TMD)[6]의 복잡한 배치를 시사한다.예측된 SOAT1 TMD의 1차 배열은 지질 이중층 [7]내에 여러 개의 대전 잔류물이 존재하는 것과 같은 많은 특이한 TMD 특징을 나타낸다.이러한 특성은 TMD를 막의 소수성 단계로 통합하는 데 어려움을 줄 수 있으므로 전문 보호자가 필요할 수 있습니다.SOAT1 생성을 돕는 그러한 샤페론의 첫 번째 힌트는 SOAT1 안정성 [8]유지에 분자 샤페론 및 일체막 단백질 삽입효소인 ER막 단백질 복합체(EMC)의 관여를 인식한 것이다.
인터랙티브 패스 맵
아래의 유전자, 단백질 및 대사물을 클릭하여 각각의 기사와 연결하세요. [§ 1]
Statin 경로 편집
- ^ 대화형 경로 맵은 WikiPathways에서 편집할 수 있습니다."Statin_Pathway_WP430".
「 」를 참조해 주세요.
레퍼런스
- ^ a b c GRCh38: 앙상블 릴리즈 89: ENSG000057252 - 앙상블, 2017년 5월
- ^ a b c GRCm38: 앙상블 릴리즈 89: ENSMUSG000026600 - 앙상블, 2017년 5월
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b "Entrez Gene: SOAT1 sterol O-acyltransferase (acyl-Coenzyme A: cholesterol acyltransferase) 1".
- ^ Ma D, Wang Z, Merrikh CN, Lang KS, Lu P, Li X, Merrikh H, Rao Z, Xu W (October 2018). "Crystal structure of a membrane-bound O-acyltransferase". Nature. 562 (7726): 286–290. Bibcode:2018Natur.562..286M. doi:10.1038/s41586-018-0568-2. PMC 6529733. PMID 30283133.
- ^ Lin S, Cheng D, Liu MS, Chen J, Chang TY (August 1999). "Human acyl-CoA:cholesterol acyltransferase-1 in the endoplasmic reticulum contains seven transmembrane domains". The Journal of Biological Chemistry. 274 (33): 23276–85. doi:10.1074/jbc.274.33.23276. PMID 10438503.
- ^ Volkmar N, Thezenas ML, Louie SM, Juszkiewicz S, Nomura DK, Hegde RS, Kessler BM, Christianson JC (January 2019). "The ER membrane protein complex promotes biogenesis of sterol-related enzymes maintaining cholesterol homeostasis". Journal of Cell Science. 132 (2): jcs223453. doi:10.1242/jcs.223453. PMC 6362398. PMID 30578317.
추가 정보
- Chang TY, Chang CC, Lin S, Yu C, Li BL, Miyazaki A (June 2001). "Roles of acyl-coenzyme A:cholesterol acyltransferase-1 and -2". Current Opinion in Lipidology. 12 (3): 289–96. doi:10.1097/00041433-200106000-00008. PMID 11353332. S2CID 7310225.
- Chang CC, Noll WW, Nutile-McMenemy N, Lindsay EA, Baldini A, Chang W, Chang TY (January 1994). "Localization of acyl coenzyme A:cholesterol acyltransferase gene to human chromosome 1q25". Somatic Cell and Molecular Genetics. 20 (1): 71–4. doi:10.1007/BF02257489. PMID 8197480. S2CID 20146117.
- Chang CC, Huh HY, Cadigan KM, Chang TY (October 1993). "Molecular cloning and functional expression of human acyl-coenzyme A:cholesterol acyltransferase cDNA in mutant Chinese hamster ovary cells". The Journal of Biological Chemistry. 268 (28): 20747–55. doi:10.1074/jbc.273.52.35132. PMID 8407899.
- Chang CC, Huh HY, Cadigan KM, Chang TY (October 1993). "Molecular cloning and functional expression of human acyl-coenzyme A:cholesterol acyltransferase cDNA in mutant Chinese hamster ovary cells". The Journal of Biological Chemistry. 268 (28): 20747–55. doi:10.1074/jbc.273.52.35132. PMID 8407899.
- Oelkers P, Behari A, Cromley D, Billheimer JT, Sturley SL (October 1998). "Characterization of two human genes encoding acyl coenzyme A:cholesterol acyltransferase-related enzymes". The Journal of Biological Chemistry. 273 (41): 26765–71. doi:10.1074/jbc.273.41.26765. PMID 9756920.
- Li BL, Li XL, Duan ZJ, Lee O, Lin S, Ma ZM, Chang CC, Yang XY, Park JP, Mohandas TK, Noll W, Chan L, Chang TY (April 1999). "Human acyl-CoA:cholesterol acyltransferase-1 (ACAT-1) gene organization and evidence that the 4.3-kilobase ACAT-1 mRNA is produced from two different chromosomes". The Journal of Biological Chemistry. 274 (16): 11060–71. doi:10.1074/jbc.274.16.11060. PMID 10196189.
- Lin S, Cheng D, Liu MS, Chen J, Chang TY (August 1999). "Human acyl-CoA:cholesterol acyltransferase-1 in the endoplasmic reticulum contains seven transmembrane domains". The Journal of Biological Chemistry. 274 (33): 23276–85. doi:10.1074/jbc.274.33.23276. PMID 10438503.
- Sakashita N, Miyazaki A, Takeya M, Horiuchi S, Chang CC, Chang TY, Takahashi K (January 2000). "Localization of human acyl-coenzyme A: cholesterol acyltransferase-1 (ACAT-1) in macrophages and in various tissues". The American Journal of Pathology. 156 (1): 227–36. doi:10.1016/S0002-9440(10)64723-2. PMC 1868616. PMID 10623671.
- Guo Z, Cromley D, Billheimer JT, Sturley SL (August 2001). "Identification of potential substrate-binding sites in yeast and human acyl-CoA sterol acyltransferases by mutagenesis of conserved sequences". Journal of Lipid Research. 42 (8): 1282–91. doi:10.1016/S0022-2275(20)31579-0. PMID 11483630.
- Zhang Y, Yu C, Liu J, Spencer TA, Chang CC, Chang TY (March 2003). "Cholesterol is superior to 7-ketocholesterol or 7 alpha-hydroxycholesterol as an allosteric activator for acyl-coenzyme A:cholesterol acyltransferase 1". The Journal of Biological Chemistry. 278 (13): 11642–7. doi:10.1074/jbc.M211559200. PMID 12533546.
- Wollmer MA, Streffer JR, Tsolaki M, Grimaldi LM, Lütjohann D, Thal D, von Bergmann K, Nitsch RM, Hock C, Papassotiropoulos A (June 2003). "Genetic association of acyl-coenzyme A: cholesterol acyltransferase with cerebrospinal fluid cholesterol levels, brain amyloid load, and risk for Alzheimer's disease". Molecular Psychiatry. 8 (6): 635–8. doi:10.1038/sj.mp.4001296. PMID 12851640.
- Smith JL, Rangaraj K, Simpson R, Maclean DJ, Nathanson LK, Stuart KA, Scott SP, Ramm GA, de Jersey J (April 2004). "Quantitative analysis of the expression of ACAT genes in human tissues by real-time PCR". Journal of Lipid Research. 45 (4): 686–96. doi:10.1194/jlr.M300365-JLR200. PMID 14729857.
- Hori M, Miyazaki A, Tamagawa H, Satoh M, Furukawa K, Hakamata H, Sasaki Y, Horiuchi S (July 2004). "Up-regulation of acyl-coenzyme A:cholesterol acyltransferase-1 by transforming growth factor-beta1 during differentiation of human monocytes into macrophages" (PDF). Biochemical and Biophysical Research Communications. 320 (2): 501–5. doi:10.1016/j.bbrc.2004.05.190. PMID 15219857.
- Yang L, Chen J, Chang CC, Yang XY, Wang ZZ, Chang TY, Li BL (April 2004). "A stable upstream stem-loop structure enhances selection of the first 5'-ORF-AUG as a main start codon for translation initiation of human ACAT1 mRNA". Acta Biochimica et Biophysica Sinica. 36 (4): 259–68. doi:10.1093/abbs/36.4.259. PMID 15253151.
- Liang JJ, Oelkers P, Guo C, Chu PC, Dixon JL, Ginsberg HN, Sturley SL (October 2004). "Overexpression of human diacylglycerol acyltransferase 1, acyl-coa:cholesterol acyltransferase 1, or acyl-CoA:cholesterol acyltransferase 2 stimulates secretion of apolipoprotein B-containing lipoproteins in McA-RH7777 cells". The Journal of Biological Chemistry. 279 (43): 44938–44. doi:10.1074/jbc.M408507200. PMID 15308631.
- Yang L, Lee O, Chen J, Chen J, Chang CC, Zhou P, Wang ZZ, Ma HH, Sha HF, Feng JX, Wang Y, Yang XY, Wang L, Dong R, Ornvold K, Li BL, Chang TY (October 2004). "Human acyl-coenzyme A:cholesterol acyltransferase 1 (acat1) sequences located in two different chromosomes (7 and 1) are required to produce a novel ACAT1 isoenzyme with additional sequence at the N terminus". The Journal of Biological Chemistry. 279 (44): 46253–62. doi:10.1074/jbc.M408155200. PMID 15319423.
- Yang L, Yang JB, Chen J, Yu GY, Zhou P, Lei L, Wang ZZ, Cy Chang C, Yang XY, Chang TY, Li BL (August 2004). "Enhancement of human ACAT1 gene expression to promote the macrophage-derived foam cell formation by dexamethasone". Cell Research. 14 (4): 315–23. doi:10.1038/sj.cr.7290231. PMID 15353128.
- Bertram L, Hsiao M, Mullin K, Parkinson M, Menon R, Moscarillo TJ, Blacker D, Tanzi RE (June 2005). "ACAT1 is not associated with Alzheimer's disease in two independent family-based samples". Molecular Psychiatry. 10 (6): 522–4. doi:10.1038/sj.mp.4001646. PMID 15768051.
