크로마틴 서브패밀리의 SWI/SNF 관련 매트릭스 관련 액틴 의존성 조절기 A멤버 5는 SMARCA5 [5] [6] 단백질 이다.
기능. 이 유전자에 의해 암호화된 단백질은 ISWI 계열의 단백질의 일원입니다. 이 과의 구성원들은 헬리케이스와 ATPase 활성을 가지고 있으며 이들 유전자 주변의 염색질 구조를 변화시킴으로써 특정 유전자의 전사를 조절하는 것으로 생각된다. 이 유전자에 의해 암호화된 단백질은 RNA 중합효소 II에 의한 클래스 II 유전자 전사의 촉진제인 크로마틴 리모델링 및 간격 인자 RSF의 구성요소이다. 암호화된 단백질은 드로소필라 ISWI 염색질 리모델링 [6]
상호 작용 SMARCA5는 RAD21 ,[7] 히스톤탈아세틸라아제2 ,[7] POLL3 ,[8] SATB1 [9] [7] [8] [9] [10] [11] BAZ1A 와 상호작용하는 것 으로 나타났다.
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