SCG3 로도 알려진 Secretogranin III 는 인간 에서 SCG3 유전자에 [5] [6] 의해 암호화되는 단백질 이다.
기능. 이 유전자에 의해 코드된 단백질은 신경내분비 분비 단백질의 크로모그 라닌/시크리토그라닌 계열의 구성원이다. 그래닌은 생물학적으로 활성화된 펩타이드의 전구체 역할을 할 수 있다. 일부 그래닌은 프로호르몬의 분류 및 단백질 분해 처리에서 도우미 단백질로 기능하는 것으로 나타났다. 그러나 이 단백질의 기능은 [6] 알려지지 않았다.
레퍼런스
추가 정보 Huttner WB, Gerdes HH, Rosa P (January 1991). "The granin (chromogranin/secretogranin) family". Trends in Biochemical Sciences . 16 (1): 27–30. doi :10.1016/0968-0004(91)90012-K . PMID 2053134 . Ozawa H, Takata K (December 1995). "The granin family--its role in sorting and secretory granule formation" . Cell Structure and Function . 20 (6): 415–20. doi :10.1247/csf.20.415 . PMID 8825061 . Dopazo A, Lovenberg TW, Danielson PE, Ottiger HP, Sutcliffe JG (1994). "Primary structure of mouse secretogranin III and its absence from deficient mice". Journal of Molecular Neuroscience . 4 (4): 225–33. doi :10.1007/BF02821554 . PMID 7917832 . Holthuis JC, Jansen EJ, Martens GJ (July 1996). "Secretogranin III is a sulfated protein undergoing proteolytic processing in the regulated secretory pathway" . The Journal of Biological Chemistry . 271 (30): 17755–60. doi :10.1074/jbc.271.30.17755 . PMID 8663421 . Rong YP, Liu F, Zeng LC, Ma WJ, Wei DZ, Han ZG (July 2002). "Cloning and characterization of a novel human secretory protein: secretogranin III". Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao Acta Biochimica et Biophysica Sinica . 34 (4): 411–7. PMID 12098761 . Hosaka M, Watanabe T, Sakai Y, Uchiyama Y, Takeuchi T (October 2002). "Identification of a chromogranin A domain that mediates binding to secretogranin III and targeting to secretory granules in pituitary cells and pancreatic beta-cells" . Molecular Biology of the Cell . 13 (10): 3388–99. doi :10.1091/mbc.02-03-0040 . PMC 129953 . PMID 12388744 . Sakai Y, Hosaka M, Hira Y, Harumi T, Ohsawa Y, Wang H, Takeuchi T, Uchiyama Y, Watanabe T (February 2003). "Immunocytochemical localization of secretogranin III in the anterior lobe of male rat pituitary glands" . The Journal of Histochemistry and Cytochemistry . 51 (2): 227–38. doi :10.1177/002215540305100211 . PMID 12533531 . Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D, Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS, Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M, Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J, Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard A, Wood WI, Godowski P, Gray A (October 2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment" . Genome Research . 13 (10): 2265–70. doi :10.1101/gr.1293003 . PMC 403697 . PMID 12975309 . Hosaka M, Suda M, Sakai Y, Izumi T, Watanabe T, Takeuchi T (January 2004). "Secretogranin III binds to cholesterol in the secretory granule membrane as an adapter for chromogranin A" . The Journal of Biological Chemistry . 279 (5): 3627–34. doi :10.1074/jbc.M310104200 . PMID 14597614 . Sakai Y, Hosaka M, Yoshinaga A, Hira Y, Harumi T, Watanabe T (March 2004). "Immunocytochemical localization of secretogranin III in the endocrine pancreas of male rats" . Archives of Histology and Cytology . 67 (1): 57–64. doi :10.1679/aohc.67.57 . PMID 15125023 . Otsuki T, Ota T, Nishikawa T, Hayashi K, Suzuki Y, Yamamoto J, Wakamatsu A, Kimura K, Sakamoto K, Hatano N, Kawai Y, Ishii S, Saito K, Kojima S, Sugiyama T, Ono T, Okano K, Yoshikawa Y, Aotsuka S, Sasaki N, Hattori A, Okumura K, Nagai K, Sugano S, Isogai T (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries" . DNA Research . 12 (2): 117–26. doi :10.1093/dnares/12.2.117 . PMID 16303743 . Tanabe A, Yanagiya T, Iida A, Saito S, Sekine A, Takahashi A, Nakamura T, Tsunoda T, Kamohara S, Nakata Y, Kotani K, Komatsu R, Itoh N, Mineo I, Wada J, Funahashi T, Miyazaki S, Tokunaga K, Hamaguchi K, Shimada T, Tanaka K, Yamada K, Hanafusa T, Oikawa S, Yoshimatsu H, Sakata T, Matsuzawa Y, Kamatani N, Nakamura Y, Hotta K (March 2007). "Functional single-nucleotide polymorphisms in the secretogranin III (SCG3) gene that form secretory granules with appetite-related neuropeptides are associated with obesity" . The Journal of Clinical Endocrinology and Metabolism . 92 (3): 1145–54. doi :10.1210/jc.2006-1808 . PMID 17200173 .