R-스폰딘-3 는 RSPO3 [5] [6] [7] 단백질 이다.
기능. 이 유전자는 트롬보스폰딘 타입 1 반복 유전자 슈퍼패밀리의 구성원을 암호화한다. 또한 해당 단백질은 퓨린 상태의 시스테인 풍부 영역을 포함한다. 퓨린 유사 반복 도메인은 수용체 티로신 [7]
배아발육 중 에 RSPO3 는 배아의 꼬리눈 및 후미선암 중배엽 에서 발현된다.조직 공학 에서, R-스폰딘 3은 다능성 줄기세포 를 근축 중배엽 전구체로[8] 분화 하기 위해 사용되어 왔다.
레퍼런스 ^ a b c GRCh38: 앙상블 릴리즈 89: ENSG00000146374 - 앙상블 , 2017년 5월^ a b c GRCm38: 앙상블 릴리즈 89: ENSMUSG000019880 - 앙상블 , 2017년 5월^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Adams JC, Tucker RP (Jun 2000). "The thrombospondin type 1 repeat (TSR) superfamily: diverse proteins with related roles in neuronal development" . Developmental Dynamics . 218 (2): 280–99. doi :10.1002/(SICI)1097-0177(200006)218:2<280::AID-DVDY4>3.0.CO;2-0 PMID 10842357 . ^ Kazanskaya O, Glinka A, del Barco Barrantes I, Stannek P, Niehrs C, Wu W (Oct 2004). "R-Spondin2 is a secreted activator of Wnt/beta-catenin signaling and is required for Xenopus myogenesis" . Developmental Cell . 7 (4): 525–34. doi :10.1016/j.devcel.2004.07.019 PMID 15469841 . ^ a b "Entrez Gene: RSPO3 R-spondin 3 homolog (Xenopus laevis)" .^ Chal J, Oginuma M, Al Tanoury Z, Gobert B, Sumara O, Hick A, Bousson F, Zidouni Y, Mursch C, Moncuquet P, Tassy O, Vincent S, Miyanari A, Bera A, Garnier JM, Guevara G, Hestin M, Kennedy L, Hayashi S, Drayton B, Cherrier T, Gayraud-Morel B, Gussoni E, Relaix F, Tajbakhsh S, Pourquié O (Sep 2015). "Differentiation of pluripotent stem cells to muscle fiber to model Duchenne muscular dystrophy" . Nature Biotechnology . 33 (9): 962–9. doi :10.1038/nbt.3297 . PMID 26237517 . S2CID 21241434 .
추가 정보 Kim KA, Zhao J, Andarmani S, Kakitani M, Oshima T, Binnerts ME, Abo A, Tomizuka K, Funk WD (Jan 2006). "R-Spondin proteins: a novel link to beta-catenin activation" . Cell Cycle . 5 (1): 23–6. doi :10.4161/cc.5.1.2305 PMID 16357527 . Hannah BL, Misenheimer TM, Annis DS, Mosher DF (Mar 2003). "A polymorphism in thrombospondin-1 associated with familial premature coronary heart disease causes a local change in conformation of the Ca2+-binding repeats" . The Journal of Biological Chemistry . 278 (11): 8929–34. doi :10.1074/jbc.M211185200 PMID 12643280 . Chen JZ, Wang S, Tang R, Yang QS, Zhao E, Chao Y, Ying K, Xie Y, Mao YM (Sep 2002). "Cloning and identification of a cDNA that encodes a novel human protein with thrombospondin type I repeat domain, hPWTSR". Molecular Biology Reports . 29 (3): 287–92. doi :10.1023/A:1020479301379 . PMID 12463421 . S2CID 32362310 .
