RAD51L1

RAD51B
식별자
별칭	RAD51B, R51H2, RAD51L1, REC2, RAD51 파라로그 B
외부 ID	OMIM: 602948 MGI: 1099436 호몰로진: 50190 GeneCard: RAD51B
유전자 위치(인간)
쳇.	14번 염색체(인간)
끝	68,730,218 bp
유전자 위치(마우스)
쳇.	12번 염색체(쥐)
끝	79,814,690 bp
RNA 표현 패턴
	표현된 상단
	수근신경; ; 말뭉치 담낭; ; 폐를 끼치다; ; 콩팥을; ; 뱃속; ; 침샘; ; 결장의; ; 하트;
	추가 참조 표현식 데이터
	n/a
유전자 온톨로지
분자함수	DNA 결합; 뉴클레오티드 결합; ATP 의존적 활동, DNA에 작용; DNA 가닥 교환 활동; 단일 가닥의 DNA 결합; GO:0001948 단백질 결합; 4방향 접합 DNA 결합; 이중 가닥의 DNA 결합; 엔도독시리보뉴클레아 활동; ATP 바인딩;
셀룰러 컴포넌트	복제 포크; 핵종의; Rad51B-Rad51C-Rad51D-XRCC2 복합체; 핵의;
생물학적 과정	가닥의 침입; 전리방사선에 대한 반응; 상호 감수성 재조합; DNA 재조합; 혈액 응고; DNA 손상 자극에 대한 세포 반응; 유사 세포 주기의 G2/M 전환에 대한 양성 조절; 체세포 재조합; DNA 수리; 감수성 DNA 재조합; 균질 재조합을 통한 이중 패시브 브레이크 수리;
	출처:아미고 / 퀵고
직교체
	5890
	19363
	ENSG00000182185
	ENSMUSG00000059060
	O15315
	O35719
NM_002877; NM_13509; NM_133510; NM_001321809; NM_001321810;
	NM_001321812; NM_001321814; NM_001321815; NM_001321817; NM_0013218; NM_001321819; NM_001321821
	NM_001252562; NM_009014
NP_001308738; NP_001308739; NP_001308741; NP_001308743; NP_001308744;
	NP_001308746; NP_001308747; NP_001308748; NP_001308750; NP_002868; NP_598193; NP_598194
	NP_001239491; NP_033040
	위키다타
인간 보기/편집	마우스 보기/편집

DNA 수리 단백질 RAD51 호몰로로그 2는 인간에서 RAD51L1 유전자에 의해 암호화된 단백질이다.^[5]^[6]^[7]

함수

이 유전자에 의해 암호화된 단백질은 RAD51 단백질 계열의 일원이다.RAD51 가족 구성원은 동질 재조합에 의해 DNA 수리에 필수적인 진화적으로 보존된 단백질이다.이 단백질은 가족 구성원 RAD51C와 안정적인 이단체를 형성하고 있으며, RAD51C는 RAD51, XRCC2, XRCC3와 같은 다른 가족 구성원들과 더욱 상호작용을 한다.이 유전자의 과도한 압착은 세포 주기 G1 지연과 세포 사멸을 유발하는 것으로 밝혀졌는데, 이는 DNA 손상을 감지하는 데 이 단백질의 역할을 시사했다.구별되는 ISO 양식을 인코딩하는 대안으로 최소 3개의 분할된 대본 변형이 관찰되었다.^[7]

상호작용

RAD51L1은 RAD51C와 상호작용하는 것으로 나타났다.^[8]^[9]^[10]

참조

^ ^a ^b ^c GRCh38: 앙상블 릴리스 89: ENSG00000182185 - 앙상블, 2017년 5월
^ ^a ^b ^c GRCm38: 앙상블 릴리스 89: ENSMUSG000059060 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Rapp UR, Marshall TH (1980). "Cell surface receptors for endogenous mouse type C viral glycoproteins and epidermal growth factor: tissue distribution in vivo and possible participation in specific cell-cell interaction". J. Supramol. Struct. 14 (3): 343–52. doi:10.1002/jss.400140308. PMID 6261043.
^ Rice MC, Smith ST, Bullrich F, Havre P, Kmiec EB (August 1997). "Isolation of human and mouse genes based on homology to REC2, a recombinational repair gene from the fungus Ustilago maydis". Proc. Natl. Acad. Sci. U.S.A. 94 (14): 7417–22. doi:10.1073/pnas.94.14.7417. PMC 23836. PMID 9207106.
^ ^a ^b "Entrez Gene: RAD51L1 RAD51-like 1 (S. cerevisiae)".
^ Hussain S, Wilson JB, Medhurst AL, Hejna J, Witt E, Ananth S, Davies A, Masson JY, Moses R, West SC, de Winter JP, Ashworth A, Jones NJ, Mathew CG (June 2004). "Direct interaction of FANCD2 with BRCA2 in DNA damage response pathways". Hum. Mol. Genet. 13 (12): 1241–8. doi:10.1093/hmg/ddh135. PMID 15115758.
^ Sigurdsson S, Van Komen S, Bussen W, Schild D, Albala JS, Sung P (Dec 2001). "Mediator function of the human Rad51B-Rad51C complex in Rad51/RPA-catalyzed DNA strand exchange". Genes Dev. 15 (24): 3308–18. doi:10.1101/gad.935501. PMC 312844. PMID 11751636.
^ Miller KA, Yoshikawa DM, McConnell IR, Clark R, Schild D, Albala JS (March 2002). "RAD51C interacts with RAD51B and is central to a larger protein complex in vivo exclusive of RAD51". J. Biol. Chem. 277 (10): 8406–11. doi:10.1074/jbc.M108306200. PMID 11744692.

추가 읽기

Dreikorn K, Röhl L (1974). "Preservation and transplantation of human cadaver kidneys. Experiences with the Gamgro perfusion unit". Scand. J. Urol. Nephrol. 8 (1): 19–26. doi:10.3109/00365597409132812. PMID 4595808.
Bonaldo MF, Lennon G, Soares MB (1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Albala JS, Thelen MP, Prange C, Fan W, Christensen M, Thompson LH, Lennon GG (1997). "Identification of a novel human RAD51 homolog, RAD51B". Genomics. 46 (3): 476–9. doi:10.1006/geno.1997.5062. PMID 9441753.
Cartwright R, Dunn AM, Simpson PJ, Tambini CE, Thacker J (1998). "Isolation of novel human and mouse genes of the recA/RAD51 recombination-repair gene family". Nucleic Acids Res. 26 (7): 1653–9. doi:10.1093/nar/26.7.1653. PMC 147465. PMID 9512535.
Havre PA, Rice MC, Noe M, Kmiec EB (1998). "The human REC2/RAD51B gene acts as a DNA damage sensor by inducing G1 delay and hypersensitivity to ultraviolet irradiation". Cancer Res. 58 (20): 4733–9. PMID 9788630.
Peng L, Rice MC, Kmiec EB (1998). "Analysis of the human RAD51L1 promoter region and its activation by UV light". Genomics. 54 (3): 529–41. doi:10.1006/geno.1998.5536. PMID 9878257.
Schoenmakers EF, Huysmans C, Van de Ven WJ (1999). "Allelic knockout of novel splice variants of human recombination repair gene RAD51B in t(12;14) uterine leiomyomas". Cancer Res. 59 (1): 19–23. PMID 9892177.
Ingraham SE, Lynch RA, Kathiresan S, Buckler AJ, Menon AG (1999). "hREC2, a RAD51-like gene, is disrupted by t(12;14) (q15;q24.1) in a uterine leiomyoma". Cancer Genet. Cytogenet. 115 (1): 56–61. doi:10.1016/S0165-4608(99)00070-9. PMID 10565301.
Takata M, Sasaki MS, Sonoda E, Fukushima T, Morrison C, Albala JS, Swagemakers SM, Kanaar R, Thompson LH, Takeda S (2000). "The Rad51 paralog Rad51B promotes homologous recombinational repair". Mol. Cell. Biol. 20 (17): 6476–82. doi:10.1128/MCB.20.17.6476-6482.2000. PMC 86122. PMID 10938124.
Masson JY, Tarsounas MC, Stasiak AZ, Stasiak A, Shah R, McIlwraith MJ, Benson FE, West SC (2001). "Identification and purification of two distinct complexes containing the five RAD51 paralogs". Genes Dev. 15 (24): 3296–307. doi:10.1101/gad.947001. PMC 312846. PMID 11751635.
Wiese C, Collins DW, Albala JS, Thompson LH, Kronenberg A, Schild D (2002). "Interactions involving the Rad51 paralogs Rad51C and XRCC3 in human cells". Nucleic Acids Res. 30 (4): 1001–8. doi:10.1093/nar/30.4.1001. PMC 100332. PMID 11842112.
Liu N, Schild D, Thelen MP, Thompson LH (2002). "Involvement of Rad51C in two distinct protein complexes of Rad51 paralogs in human cells". Nucleic Acids Res. 30 (4): 1009–15. doi:10.1093/nar/30.4.1009. PMC 100342. PMID 11842113.
Blank C, Schoenmakers EF, Rogalla P, Huys EH, van Rijk AA, Drieschner N, Bullerdiek J (2001). "Intragenic breakpoint within RAD51L1 in a t(6;14)(p21.3;q24) of a pulmonary chondroid hamartoma". Cytogenet. Cell Genet. 95 (1–2): 17–9. doi:10.1159/000057011. PMID 11978964. S2CID 6715664.
Godthelp BC, Artwert F, Joenje H, Zdzienicka MZ (2002). "Impaired DNA damage-induced nuclear Rad51 foci formation uniquely characterizes Fanconi anemia group D1". Oncogene. 21 (32): 5002–5. doi:10.1038/sj.onc.1205656. PMID 12118380.
Lio YC, Mazin AV, Kowalczykowski SC, Chen DJ (2003). "Complex formation by the human Rad51B and Rad51C DNA repair proteins and their activities in vitro". J. Biol. Chem. 278 (4): 2469–78. doi:10.1074/jbc.M211038200. PMID 12427746.
Yokoyama H, Kurumizaka H, Ikawa S, Yokoyama S, Shibata T (2003). "Holliday junction binding activity of the human Rad51B protein". J. Biol. Chem. 278 (4): 2767–72. doi:10.1074/jbc.M210899200. PMID 12441335.

14번 염색체의 유전자에 관한 이 기사는 단조롭다.위키피디아를 확장하여 도울 수 있다.

[refGRCh38Ensembl-1] GRCh38: 앙상블 릴리스 89: ENSG00000182185 - 앙상블, 2017년 5월

[refGRCm38Ensembl-2] GRCm38: 앙상블 릴리스 89: ENSMUSG000059060 - 앙상블, 2017년 5월

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid6261043-5] Rapp UR, Marshall TH (1980). "Cell surface receptors for endogenous mouse type C viral glycoproteins and epidermal growth factor: tissue distribution in vivo and possible participation in specific cell-cell interaction". J. Supramol. Struct. 14 (3): 343–52. doi:10.1002/jss.400140308. PMID 6261043.

[pmid9207106-6] Rice MC, Smith ST, Bullrich F, Havre P, Kmiec EB (August 1997). "Isolation of human and mouse genes based on homology to REC2, a recombinational repair gene from the fungus Ustilago maydis". Proc. Natl. Acad. Sci. U.S.A. 94 (14): 7417–22. doi:10.1073/pnas.94.14.7417. PMC 23836. PMID 9207106.

[entrez-7] "Entrez Gene: RAD51L1 RAD51-like 1 (S. cerevisiae)".

[pmid15115758-8] Hussain S, Wilson JB, Medhurst AL, Hejna J, Witt E, Ananth S, Davies A, Masson JY, Moses R, West SC, de Winter JP, Ashworth A, Jones NJ, Mathew CG (June 2004). "Direct interaction of FANCD2 with BRCA2 in DNA damage response pathways". Hum. Mol. Genet. 13 (12): 1241–8. doi:10.1093/hmg/ddh135. PMID 15115758.

[pmid11751636-9] Sigurdsson S, Van Komen S, Bussen W, Schild D, Albala JS, Sung P (Dec 2001). "Mediator function of the human Rad51B-Rad51C complex in Rad51/RPA-catalyzed DNA strand exchange". Genes Dev. 15 (24): 3308–18. doi:10.1101/gad.935501. PMC 312844. PMID 11751636.

[pmid11744692-10] Miller KA, Yoshikawa DM, McConnell IR, Clark R, Schild D, Albala JS (March 2002). "RAD51C interacts with RAD51B and is central to a larger protein complex in vivo exclusive of RAD51". J. Biol. Chem. 277 (10): 8406–11. doi:10.1074/jbc.M108306200. PMID 11744692.

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RAD51L1

네임스페이스

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목차

함수

상호작용

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