RAB11FIP3

RAB11FIP3
사용 가능한 구조
PDB	Ortholog 검색: PDBe RCSB
PDB ID 코드 목록
	2D7C, 2HV8, 4D0M, 4UJ3, 4UJ4
식별자
에일리어스	RAB11FIP3, CART1, Rab11-FIP3, RAB11 패밀리 상호작용 단백질3, FIP3-Rab11
외부 ID	OMIM: 608738 MGI: 2444431 HomoloGene: 49396 GenCard: RAB11FIP3
유전자 위치(인간)
크르.	16번 염색체(인간)
끝.	523,011 bp
유전자 위치(마우스)
크르.	다운로드.
끝.	26,288,529 bp
RNA발현패턴
	상단 표시 위치:
	췌관 세포; ; 신장; ; 상부 신경; ; 신장수질; ; 신장 피질; ; 내장 흉막; ; 대상회; ; 췌장체; ; 뇌하수체; ; 뇌하수체 전엽;
	추가 참조 표현식 데이터
	추가 참조 표현식 데이터
유전자 존재론
분자 함수	칼슘 이온 결합; 단백질 호모다이머화; 금속 이온 결합; GO:0001948 단백질 결합; 다이닌광중간사슬결합;
셀룰러 컴포넌트	세포질; 재활용 엔도솜; 세포; 내염색체; 중심체; 세포막내소기관; 막; 핵소체; 미소관 조직 센터; 재활용 엔도솜막; 미드바디; 세포간 교량; 갈라진 이랑; 세포골격; 세포내 소포;
생물학적 과정	세포 분열; 세포내 재활용; 세포 주기; 아디포넥틴 분비 음성 조절; 소포체 수송; 사이토키네시스; 사이토키네시스 조절; 섬모에 대한 단백질 국재;
	출처:아미고 / QuickGO
맞춤법
	9727
	215445
	ENSG000090565; ENSG00000275338
	ENSMUSG000037098
	O75154
	Q8CHD8
	NM_001142272; NM_014700; NM_001370401
	NM_001162868; NM_001162869; NM_153140
	NP_001135744; NP_055515; NP_001357330
	NP_001156340; NP_001156341; NP_694780
	위키데이터
인간 보기/편집	마우스 표시/편집

Rab11 패밀리 인터랙션 단백질 3은 사람에게서 Rab11에 의해 암호화되는 단백질이다.FIP3 ^[5]^[6]^[7]유전자

큰 Rab GTPase 계열의 단백질(RAB1A; MIM 179508 참조)은 세포 내 수송 소포의 형성, 표적화 및 융합에 조절 역할을 한다.RAB11FIP3는 Rab GTPase와 상호작용하고 조절하는 많은 단백질 중 하나이다(Hales et al.,[OMIM ^[7]제공]

상호 작용

RAB11FIP3는 RAB11A와 ^[8]상호 작용하는 것으로 나타났습니다.

레퍼런스

^ ^a ^b ^c ENSG00000275338 GRCh38: 앙상블 릴리즈 89: ENSG00000090565, ENSG00000275338: Ensembl, 2017년 5월
^ ^a ^b ^c GRCm38: 앙상블 릴리즈 89: ENSMUSG000037098 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Dec 1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (3): 169–76. doi:10.1093/dnares/5.3.169. PMID 9734811.
^ Prekeris R, Davies JM, Scheller RH (October 2001). "Identification of a novel Rab11/25 binding domain present in Eferin and Rip proteins". J Biol Chem. 276 (42): 38966–70. doi:10.1074/jbc.M106133200. PMID 11481332.
^ ^a ^b "Entrez Gene: RAB11FIP3 RAB11 family interacting protein 3 (class II)".
^ Hales, C M; Griner R; Hobdy-Henderson K C; Dorn M C; Hardy D; Kumar R; Navarre J; Chan E K; Lapierre L A; Goldenring J R (October 2001). "Identification and characterization of a family of Rab11-interacting proteins". J. Biol. Chem. United States. 276 (42): 39067–75. doi:10.1074/jbc.M104831200. ISSN 0021-9258. PMID 11495908.

추가 정보

Shin OH, Ross AH, Mihai I, Exton JH (2000). "Identification of arfophilin, a target protein for GTP-bound class II ADP-ribosylation factors". J. Biol. Chem. 274 (51): 36609–15. doi:10.1074/jbc.274.51.36609. PMID 10593962.
Daniels RJ, Peden JF, Lloyd C, et al. (2001). "Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16". Hum. Mol. Genet. 10 (4): 339–52. doi:10.1093/hmg/10.4.339. PMID 11157797.
Hales CM, Griner R, Hobdy-Henderson KC, et al. (2001). "Identification and characterization of a family of Rab11-interacting proteins". J. Biol. Chem. 276 (42): 39067–75. doi:10.1074/jbc.M104831200. PMID 11495908.
Shin OH, Couvillon AD, Exton JH (2001). "Arfophilin is a common target of both class II and class III ADP-ribosylation factors". Biochemistry. 40 (36): 10846–52. doi:10.1021/bi0107391. PMID 11535061.
Yang CS, Weiner H (2002). "Yeast two-hybrid screening identifies binding partners of human Tom34 that have ATPase activity and form a complex with Tom34 in the cytosol". Arch. Biochem. Biophys. 400 (1): 105–10. doi:10.1006/abbi.2002.2778. PMID 11913976.
Wallace DM, Lindsay AJ, Hendrick AG, McCaffrey MW (2003). "Rab11-FIP4 interacts with Rab11 in a GTP-dependent manner and its overexpression condenses the Rab11 positive compartment in HeLa cells". Biochem. Biophys. Res. Commun. 299 (5): 770–9. doi:10.1016/S0006-291X(02)02720-1. PMID 12470645.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Behrends U, Schneider I, Rössler S, et al. (2003). "Novel tumor antigens identified by autologous antibody screening of childhood medulloblastoma cDNA libraries". Int. J. Cancer. 106 (2): 244–51. doi:10.1002/ijc.11208. PMID 12800201. S2CID 36836051.
Horgan CP, Walsh M, Zurawski TH, McCaffrey MW (2004). "Rab11-FIP3 localises to a Rab11-positive pericentrosomal compartment during interphase and to the cleavage furrow during cytokinesis". Biochem. Biophys. Res. Commun. 319 (1): 83–94. doi:10.1016/j.bbrc.2004.04.157. PMID 15158446.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Wilson GM, Fielding AB, Simon GC, et al. (2005). "The FIP3-Rab11 protein complex regulates recycling endosome targeting to the cleavage furrow during late cytokinesis". Mol. Biol. Cell. 16 (2): 849–60. doi:10.1091/mbc.E04-10-0927. PMC 545916. PMID 15601896.
Martin J, Han C, Gordon LA, et al. (2005). "The sequence and analysis of duplication-rich human chromosome 16". Nature. 432 (7020): 988–94. Bibcode:2004Natur.432..988M. doi:10.1038/nature03187. PMID 15616553.
Shiba T, Koga H, Shin HW, et al. (2007). "Structural basis for Rab11-dependent membrane recruitment of a family of Rab11-interacting protein 3 (FIP3)/Arfophilin-1". Proc. Natl. Acad. Sci. U.S.A. 103 (42): 15416–21. Bibcode:2006PNAS..10315416S. doi:10.1073/pnas.0605357103. PMC 1622838. PMID 17030804.
Horgan CP, Oleksy A, Zhdanov AV, et al. (2007). "Rab11-FIP3 is critical for the structural integrity of the endosomal recycling compartment" (PDF). Traffic. 8 (4): 414–30. doi:10.1111/j.1600-0854.2007.00543.x. PMID 17394487.
Schonteich E, Pilli M, Simon GC, et al. (2007). "Molecular characterization of Rab11-FIP3 binding to ARF GTPases". Eur. J. Cell Biol. 86 (8): 417–31. doi:10.1016/j.ejcb.2007.05.004. PMID 17628206.

인간 염색체 16번 유전자에 대한 이 기사는 짧은 글이다.위키피디아를 확장함으로써 위키피디아를 도울 수 있습니다.

[refGRCh38Ensembl-1] ENSG00000275338 GRCh38: 앙상블 릴리즈 89: ENSG00000090565, ENSG00000275338: Ensembl, 2017년 5월

[refGRCm38Ensembl-2] GRCm38: 앙상블 릴리즈 89: ENSMUSG000037098 - 앙상블, 2017년 5월

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9734811-5] Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Dec 1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (3): 169–76. doi:10.1093/dnares/5.3.169. PMID 9734811.

[pmid11481332-6] Prekeris R, Davies JM, Scheller RH (October 2001). "Identification of a novel Rab11/25 binding domain present in Eferin and Rip proteins". J Biol Chem. 276 (42): 38966–70. doi:10.1074/jbc.M106133200. PMID 11481332.

[entrez-7] "Entrez Gene: RAB11FIP3 RAB11 family interacting protein 3 (class II)".

[pmid11495908-8] Hales, C M; Griner R; Hobdy-Henderson K C; Dorn M C; Hardy D; Kumar R; Navarre J; Chan E K; Lapierre L A; Goldenring J R (October 2001). "Identification and characterization of a family of Rab11-interacting proteins". J. Biol. Chem. United States. 276 (42): 39067–75. doi:10.1074/jbc.M104831200. ISSN 0021-9258. PMID 11495908.

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RAB11FIP3

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상호 작용

레퍼런스

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