중합효소 델타상호작용단백질 3은 POLDIP3 [5] [6] 효소 이다.
이 유전자는 DNA 중합효소 델타 p50 서브유닛과 상호작용하는 단백질을 암호화한다. 이 단백질은 S6 키나아제 1의 특정 표적이며 세포 성장을 조절합니다. 서로 다른 단백질 아이소폼을 코드하는 두 가지 전사 변종이 확인되었다.[6]
상호 작용 POLDIP3는 P70-S6 키나제 [7] 것 으로 나타났다.
레퍼런스 ^ a b c GRCh38: 앙상블 릴리즈 89: ENSG00000100227 - 앙상블 , 2017년 5월^ a b c GRCm38: 앙상블 릴리즈 89: ENSMUSG000041815 - 앙상블 , 2017년 5월^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Liu L, Rodriguez-Belmonte EM, Mazloum N, Xie B, Lee MY (Mar 2003). "Identification of a novel protein, PDIP38, that interacts with the p50 subunit of DNA polymerase delta and proliferating cell nuclear antigen" . J Biol Chem . 278 (12): 10041–7. doi :10.1074/jbc.M208694200 PMID 12522211 . ^ a b "Entrez Gene: POLDIP3 polymerase (DNA-directed), delta interacting protein 3" .^ Richardson, Celeste J; Bröenstrup Mark; Fingar Diane C; Jülich Kristina; Ballif Bryan A; Gygi Steven; Blenis John (Sep 2004). "SKAR is a specific target of S6 kinase 1 in cell growth control" . Curr. Biol . England. 14 (17): 1540–9. doi :10.1016/j.cub.2004.08.061 ISSN 0960-9822 . PMID 15341740 .
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