호모 사피엔스 종의 단백질 코드 유전자
플렉신 A2는 PLXNA2 [5] [6] 단백질 이다.
이 유전자는 세마포린 공동수용체 의 플렉신-A 패밀리 멤버를 암호화합니다. 세마포린은 신경계가 발달하는 동안 축삭 경로 탐색에 대한 거부 효과를 중재하는 분비되거나 막 결합 단백질의 큰 패밀리입니다. 세마포린의 서브셋은 플렉신-A/뉴로필린 트랜스막 수용체 복합체에 의해 인식되어 축삭 반발을 일으키는 세포 신호 전달 캐스케이드를 트리거한다. 이 플렉신-A 계열은 세마포린-3A 및 [6]
일부 연구에서 PLXNA2 유전자는 정신분열증 과 [7] 걱정 도 많이 하고 있어.PLXNA2는 지적 장애 및 안면 이상 및 선천성 심장[8] [9]
레퍼런스 ^ a b c GRCh38: 앙상블 릴리즈 89: ENSG000076356 - 앙상블 , 2017년 5월^ a b c GRCm38: 앙상블 릴리즈 89: ENSMUSG000026640 - 앙상블 , 2017년 5월^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Maestrini E, Tamagnone L, Longati P, Cremona O, Gulisano M, Bione S, Tamanini F, Neel BG, Toniolo D, Comoglio PM (Mar 1996). "A family of transmembrane proteins with homology to the MET-hepatocyte growth factor receptor" . Proc Natl Acad Sci USA . 93 (2): 674–8. Bibcode :1996PNAS...93..674M . doi :10.1073/pnas.93.2.674 PMC 40111 PMID 8570614 . ^ a b "Entrez Gene: PLXNA2 plexin A2" .^ "Gene Overview of All Published Schizophrenia-Association Studies for PLXNA2" . Schizophrenia Research Forum the original on 21 February 2009.^ Altuame FD, Shamseldin HE, Albatti TH, Hashem M, Ewida N, Abdulwahab F, Alkuraya FS (July 2021). "PLXNA2 as a candidate gene in patients with intellectual disability". American Journal of Medical Genetics. Part A . doi :10.1002/ajmg.a.62440 . PMID 34327814 . S2CID 236516392 . ^ Wray NR, James MR, Mah SP, Nelson M, Andrews G, Sullivan PF, et al. (March 2007). "Anxiety and comorbid measures associated with PLXNA2" . Archives of General Psychiatry . 64 (3): 318–26. doi :10.1001/archpsyc.64.3.318 PMID 17339520 . 추가 정보 Negishi M, Oinuma I, Katoh H (2005). "Plexins: axon guidance and signal transduction". Cell. Mol. Life Sci . 62 (12): 1363–71. doi :10.1007/s00018-005-5018-2 . PMID 15818466 . S2CID 32299864 . Seki N, Ohira M, Nagase T, et al. (1998). "Characterization of cDNA clones in size-fractionated cDNA libraries from human brain" . DNA Res . 4 (5): 345–9. doi :10.1093/dnares/4.5.345 PMID 9455484 . Tamagnone L, Artigiani S, Chen H, et al. (1999). "Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates" . Cell . 99 (1): 71–80. doi :10.1016/S0092-8674(00)80063-X PMID 10520995 . S2CID 17386412 . Nakayama M, Kikuno R, Ohara O (2003). "Protein–Protein Interactions Between Large Proteins: Two-Hybrid Screening Using a Functionally Classified Library Composed of Long cDNAs" . Genome Res . 12 (11): 1773–84. doi :10.1101/gr.406902 . PMC 187542 PMID 12421765 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment" . Genome Res . 13 (10): 2265–70. doi :10.1101/gr.1293003 . PMC 403697 PMID 12975309 . Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5. doi :10.1038/ng1285 PMID 14702039 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes" . Genome Res . 16 (1): 55–65. doi :10.1101/gr.4039406 . PMC 1356129 PMID 16344560 . Mah S, Nelson MR, Delisi LE, et al. (2006). "Identification of the semaphorin receptor PLXNA2 as a candidate for susceptibility to schizophrenia" . Mol. Psychiatry . 11 (5): 471–8. doi :10.1038/sj.mp.4001785 PMID 16402134 . Fujii T, Iijima Y, Kondo H, et al. (2007). "Failure to confirm an association between the PLXNA2 gene and schizophrenia in a Japanese population". Prog. Neuropsychopharmacol. Biol. Psychiatry . 31 (4): 873–7. doi :10.1016/j.pnpbp.2007.01.027 . PMID 17346868 . S2CID 46003583 .
