PCGF2

PCGF2
식별자
에일리어스	PCGF2, MEL-18, RNF110, ZNF144, 폴리콤 그룹 링 핑거2, TPFS
외부 ID	OMIM: 600346 MGI: 99161 HomoloGene: 5174 GenCard: PCGF2
유전자 위치(인간)
크르.	17번 염색체(인간)
끝.	38,749,817 bp
유전자 위치(마우스)
크르.	11번 염색체(쥐)
끝.	97,591,323 bp
RNA발현패턴
	상단 표시 위치:
	신경절 융기; ; 자궁내막간질세포; ; 뇌하수체; ; 뇌하수체 전엽; ; 자궁경관; ; 신장; ; 갑상선 좌엽; ; 갑상선 우엽; ; 상행 대동맥; ; 우측 자궁관;
	추가 참조 표현식 데이터
	; ; ; ;
	추가 참조 표현식 데이터
유전자 존재론
분자 함수	금속 이온 결합; 크로마틴 결합; GO:0001131, GO:000115, GO:0001130, GO:0001204 DNA결합전사인자액티비티; DNA결합; GO:0001948, GO:0016582 단백질 결합; 프로모터 특이 크로마틴 결합;
셀룰러 컴포넌트	핵소체; 핵; 성염색질; 핵체; PcG단백질복합체; PRC1 복합체;
생물학적 과정	전방/전방 패턴 사양; 전사, DNA 템플릿; 아포토시스 시그널링 경로의 음성 조절; 배아 골격계 형태 형성; 과산화수소에 대한 세포반응; 히스톤 아세틸화; 자궁 내 태아 발달; GO:0009373 전사 조절, DNA 템플릿; 배아 골격계 발달; GO:1901227 RNA 중합효소 II에 의한 전사 음성 조절; 히스톤 H2A-K119 단염화; G0에서 G1로의 이행에 대한 부정적 조절;
	출처:아미고 / QuickGO
맞춤법
	7703
	22658
	ENSG00000277258; ENSG00000278644
	ENSMUSG000018537
	P35227
	P23798
	NM_007144; NM_001369614; NM_001369615
	NM_001163307; NM_001163308; NM_009545
	NP_009075; NP_001356543; NP_001356544
	NP_001156779; NP_001156780; NP_033571
	위키데이터
인간 보기/편집	마우스 표시/편집

MEL18 또는 RNF110으로 알려진 폴리콤 그룹 RING 핑거 단백질 2, PCGF2는 사람에게서 PCGF2 ^[5]^[6]유전자에 의해 암호화되는 단백질이다.

기능.

이 유전자에 의해 암호화된 단백질은 RING 손가락 모티브를 포함하고 있다.정식 PRC1 단지 RING1A/B, CBX2/CBX4,polyhomeotic(PHC파일)단백질과 구성된 PCGF2 부품은 PCGF4/BMI1과 비슷하다는 H3K27me3 마크 PRC2.[9][10]정규 PRC1 단지에 의해 쌓인를 인식하는 Computerized소단위의 chromodomain을 통해 chromatin에 PRC1.[7][8]정규 PRC1 자식을 포함하기 위해서는 보여 왔다o 콤팩트 ch고차 염색질 ^[11]^[12]^[13]구조를 매개하는 역할을 합니다.

폴리콤 복합체는 배아 발생, 세포 주기 및 종양 발생과 관련된 유전자의 전사 억제를 유지한다.PCGF2는 전사 음성 조절기로 작용하며 종양 억제제 활성을 가지고 있는 것으로 나타났다.이 유전자의 발현은 다양한 종양 세포에서 검출되었지만, 정상 조직의 신경 기관에서는 제한적입니다.생쥐를 대상으로 한 녹아웃 연구는 이 단백질이 다른 사이토카인, 케모카인 수용체의 발현을 부정적으로 조절할 수 있으며, 따라서 면역 ^[6]반응뿐만 아니라 림프구 분화와 이동에 중요한 역할을 한다는 것을 시사했다.

레퍼런스

^ ^a ^b ^c ENSG00000278644 GRCh38: 앙상블 릴리즈 89: ENSG00000277258, ENSG00000278644 - Ensembl, 2017년 5월
^ ^a ^b ^c GRCm38: 앙상블 릴리즈 89: ENSMUSG000018537 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Ishida A, Asano H, Hasegawa M, Koseki H, Ono T, Yoshida MC, Taniguchi M, Kanno M (July 1993). "Cloning and chromosome mapping of the human Mel-18 gene which encodes a DNA-binding protein with a new 'RING-finger' motif". Gene. 129 (2): 249–55. doi:10.1016/0378-1119(93)90275-8. PMID 8325509.
^ ^a ^b "Entrez Gene: PCGF2 polycomb group ring finger 2".
^ Gao Z, Zhang J, Bonasio R, Strino F, Sawai A, Parisi F, et al. (February 2012). "PCGF homologs, CBX proteins, and RYBP define functionally distinct PRC1 family complexes". Molecular Cell. 45 (3): 344–56. doi:10.1016/j.molcel.2012.01.002. PMC 3293217. PMID 22325352.
^ Hauri S, Comoglio F, Seimiya M, Gerstung M, Glatter T, Hansen K, et al. (October 2016). "A High-Density Map for Navigating the Human Polycomb Complexome". Cell Reports. 17 (2): 583–595. doi:10.1016/j.celrep.2016.08.096. PMID 27705803.
^ Bernstein E, Duncan EM, Masui O, Gil J, Heard E, Allis CD (April 2006). "Mouse polycomb proteins bind differentially to methylated histone H3 and RNA and are enriched in facultative heterochromatin". Molecular and Cellular Biology. 26 (7): 2560–9. doi:10.1128/MCB.26.7.2560-2569.2006. PMC 1430336. PMID 16537902.
^ Cao R, Wang L, Wang H, Xia L, Erdjument-Bromage H, Tempst P, et al. (November 2002). "Role of histone H3 lysine 27 methylation in Polycomb-group silencing". Science. 298 (5595): 1039–43. doi:10.1126/science.1076997. PMID 12351676.
^ Fursova NA, Blackledge NP, Nakayama M, Ito S, Koseki Y, Farcas AM, et al. (June 2019). "Synergy between Variant PRC1 Complexes Defines Polycomb-Mediated Gene Repression". Molecular Cell. 74 (5): 1020–1036.e8. doi:10.1016/j.molcel.2019.03.024. PMC 6561741. PMID 31029541.
^ Blackledge NP, Fursova NA, Kelley JR, Huseyin MK, Feldmann A, Klose RJ (February 2020). "PRC1 Catalytic Activity Is Central to Polycomb System Function". Molecular Cell. 77 (4): 857–874.e9. doi:10.1016/j.molcel.2019.12.001. PMC 7033600. PMID 31883950.
^ Boyle S, Flyamer IM, Williamson I, Sengupta D, Bickmore WA, Illingworth RS (July 2020). "A central role for canonical PRC1 in shaping the 3D nuclear landscape". Genes & Development. 34 (13–14): 931–949. doi:10.1101/gad.336487.120. PMC 7328521. PMID 32439634.

추가 정보

Hartley JL, Temple GF, Brasch MA (November 2000). "DNA cloning using in vitro site-specific recombination". Genome Research. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (March 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
Kimura M, Koseki Y, Yamashita M, Watanabe N, Shimizu C, Katsumoto T, Kitamura T, Taniguchi M, Koseki H, Nakayama T (August 2001). "Regulation of Th2 cell differentiation by mel-18, a mammalian polycomb group gene". Immunity. 15 (2): 275–87. doi:10.1016/S1074-7613(01)00182-0. PMID 11520462.
Miyazaki K, Inoue H, Onai N, Ishihara H, Kanno M (February 2002). "Chemokine-mediated thymopoiesis is regulated by a mammalian Polycomb group gene, mel-18". Immunology Letters. 80 (2): 139–43. doi:10.1016/S0165-2478(01)00315-7. PMID 11750047.
Levine SS, Weiss A, Erdjument-Bromage H, Shao Z, Tempst P, Kingston RE (September 2002). "The core of the polycomb repressive complex is compositionally and functionally conserved in flies and humans". Molecular and Cellular Biology. 22 (17): 6070–8. doi:10.1128/MCB.22.17.6070-6078.2002. PMC 134016. PMID 12167701.
Suzuki M, Mizutani-Koseki Y, Fujimura Y, Miyagishima H, Kaneko T, Takada Y, Akasaka T, Tanzawa H, Takihara Y, Nakano M, Masumoto H, Vidal M, Isono K, Koseki H (September 2002). "Involvement of the Polycomb-group gene Ring1B in the specification of the anterior-posterior axis in mice". Development. 129 (18): 4171–83. PMID 12183370.
Matsuo F, Yano K, Saito H, Morotomi K, Kato M, Yoshimoto M, Kasumi F, Akiyama F, Sakamoto G, Miki Y (2002). "Mutation analysis of the mel-18 gene that shows decreased expression in human breast cancer cell lines". Breast Cancer. 9 (1): 33–8. doi:10.1007/BF02967544. PMID 12196719. S2CID 26605827.
Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A (October 2004). "From ORFeome to biology: a functional genomics pipeline". Genome Research. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (January 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S (January 2006). "The LIFEdb database in 2006". Nucleic Acids Research. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
Silva J, García JM, Peña C, García V, Domínguez G, Suárez D, Camacho FI, Espinosa R, Provencio M, España P, Bonilla F (December 2006). "Implication of polycomb members Bmi-1, Mel-18, and Hpc-2 in the regulation of p16INK4a, p14ARF, h-TERT, and c-Myc expression in primary breast carcinomas". Clinical Cancer Research. 12 (23): 6929–36. doi:10.1158/1078-0432.CCR-06-0788. PMID 17145810.
Guo WJ, Datta S, Band V, Dimri GP (February 2007). "Mel-18, a polycomb group protein, regulates cell proliferation and senescence via transcriptional repression of Bmi-1 and c-Myc oncoproteins". Molecular Biology of the Cell. 18 (2): 536–46. doi:10.1091/mbc.E06-05-0447. PMC 1783768. PMID 17151361.
Wiederschain D, Chen L, Johnson B, Bettano K, Jackson D, Taraszka J, Wang YK, Jones MD, Morrissey M, Deeds J, Mosher R, Fordjour P, Lengauer C, Benson JD (July 2007). "Contribution of polycomb homologues Bmi-1 and Mel-18 to medulloblastoma pathogenesis". Molecular and Cellular Biology. 27 (13): 4968–79. doi:10.1128/MCB.02244-06. PMC 1951487. PMID 17452456.
Guo WJ, Zeng MS, Yadav A, Song LB, Guo BH, Band V, Dimri GP (June 2007). "Mel-18 acts as a tumor suppressor by repressing Bmi-1 expression and down-regulating Akt activity in breast cancer cells". Cancer Research. 67 (11): 5083–9. doi:10.1158/0008-5472.CAN-06-4368. PMC 2386662. PMID 17545584.
Szafranski K, Schindler S, Taudien S, Hiller M, Huse K, Jahn N, Schreiber S, Backofen R, Platzer M (2007). "Violating the splicing rules: TG dinucleotides function as alternative 3' splice sites in U2-dependent introns". Genome Biology. 8 (8): R154. doi:10.1186/gb-2007-8-8-r154. PMC 2374985. PMID 17672918.

인간 염색체 17번 유전자에 대한 이 기사는 짧은 글이다.위키피디아를 확장함으로써 위키피디아를 도울 수 있습니다.

[refGRCh38Ensembl-1] ENSG00000278644 GRCh38: 앙상블 릴리즈 89: ENSG00000277258, ENSG00000278644 - Ensembl, 2017년 5월

[refGRCm38Ensembl-2] GRCm38: 앙상블 릴리즈 89: ENSMUSG000018537 - 앙상블, 2017년 5월

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8325509-5] Ishida A, Asano H, Hasegawa M, Koseki H, Ono T, Yoshida MC, Taniguchi M, Kanno M (July 1993). "Cloning and chromosome mapping of the human Mel-18 gene which encodes a DNA-binding protein with a new 'RING-finger' motif". Gene. 129 (2): 249–55. doi:10.1016/0378-1119(93)90275-8. PMID 8325509.

[entrez-6] "Entrez Gene: PCGF2 polycomb group ring finger 2".

[7] Gao Z, Zhang J, Bonasio R, Strino F, Sawai A, Parisi F, et al. (February 2012). "PCGF homologs, CBX proteins, and RYBP define functionally distinct PRC1 family complexes". Molecular Cell. 45 (3): 344–56. doi:10.1016/j.molcel.2012.01.002. PMC 3293217. PMID 22325352.

[8] Hauri S, Comoglio F, Seimiya M, Gerstung M, Glatter T, Hansen K, et al. (October 2016). "A High-Density Map for Navigating the Human Polycomb Complexome". Cell Reports. 17 (2): 583–595. doi:10.1016/j.celrep.2016.08.096. PMID 27705803.

[9] Bernstein E, Duncan EM, Masui O, Gil J, Heard E, Allis CD (April 2006). "Mouse polycomb proteins bind differentially to methylated histone H3 and RNA and are enriched in facultative heterochromatin". Molecular and Cellular Biology. 26 (7): 2560–9. doi:10.1128/MCB.26.7.2560-2569.2006. PMC 1430336. PMID 16537902.

[10] Cao R, Wang L, Wang H, Xia L, Erdjument-Bromage H, Tempst P, et al. (November 2002). "Role of histone H3 lysine 27 methylation in Polycomb-group silencing". Science. 298 (5595): 1039–43. doi:10.1126/science.1076997. PMID 12351676.

[11] Fursova NA, Blackledge NP, Nakayama M, Ito S, Koseki Y, Farcas AM, et al. (June 2019). "Synergy between Variant PRC1 Complexes Defines Polycomb-Mediated Gene Repression". Molecular Cell. 74 (5): 1020–1036.e8. doi:10.1016/j.molcel.2019.03.024. PMC 6561741. PMID 31029541.

[12] Blackledge NP, Fursova NA, Kelley JR, Huseyin MK, Feldmann A, Klose RJ (February 2020). "PRC1 Catalytic Activity Is Central to Polycomb System Function". Molecular Cell. 77 (4): 857–874.e9. doi:10.1016/j.molcel.2019.12.001. PMC 7033600. PMID 31883950.

[13] Boyle S, Flyamer IM, Williamson I, Sengupta D, Bickmore WA, Illingworth RS (July 2020). "A central role for canonical PRC1 in shaping the 3D nuclear landscape". Genes & Development. 34 (13–14): 931–949. doi:10.1101/gad.336487.120. PMC 7328521. PMID 32439634.

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PCGF2

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기능.

레퍼런스

추가 정보