OST-alpha 라고도 알려진 유기용질수송체 알파는 인간 의 OSTA [5] [6] 단백질 이다.
기능. OST-alpha는 OST-베타 와 함께 에스트론 황산염, 타우로콜라트 , 디곡신 , 프로스타글란딘 E2 를 세포막 을 [6] [7] 가로질러 운반할 수 있다. 개별 서브유닛이 아닌 Ost-alpha/Ost-beta 헤테로디머는 나트륨 비의존성 담즙산 [7] 또한 헤테로디머는 장내 담즙산 [8]
OST-alpha와 OST-alpha는 고환, 대장, 간, 소장, 신장, 난소,[6]
「 」를 참조해 주세요. 레퍼런스 ^ a b c GRCh38: 앙상블 릴리즈 89: ENSG00000163959 - 앙상블 , 2017년 5월^ a b c GRCm38: 앙상블 릴리즈 89: ENSMUSG000035699 - 앙상블 , 2017년 5월^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Entrez Gene: OSTalpha organic solute transporter alpha" .^ a b c Seward DJ, Koh AS, Boyer JL, Ballatori N (July 2003). "Functional complementation between a novel mammalian polygenic transport complex and an evolutionarily ancient organic solute transporter, OSTalpha-OSTbeta" . J. Biol. Chem . 278 (30): 27473–82. doi :10.1074/jbc.M301106200 PMID 12719432 . ^ a b Dawson PA, Hubbert M, Haywood J, Craddock AL, Zerangue N, Christian WV, Ballatori N (February 2005). "The Heteromeric Organic Solute Transporter α-β, Ostα-Ostβ, Is an Ileal Basolateral Bile Acid Transporter" . J. Biol. Chem . 280 (8): 6960–8. doi :10.1074/jbc.M412752200 PMC 1224727 PMID 15563450 . ^ Rao A, Haywood J, Craddock AL, Belinsky MG, Kruh GD, Dawson PA (March 2008). "The organic solute transporter α-β, Ostα-Ostβ, is essential for intestinal bile acid transport and homeostasis" . Proc. Natl. Acad. Sci. U.S.A . 105 (10): 3891–6. Bibcode :2008PNAS..105.3891R . doi :10.1073/pnas.0712328105 PMC 2268840 PMID 18292224 . 추가 정보 Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Seward DJ, Koh AS, Boyer JL, Ballatori N (2003). "Functional complementation between a novel mammalian polygenic transport complex and an evolutionarily ancient organic solute transporter, OSTalpha-OSTbeta" . J. Biol. Chem . 278 (30): 27473–82. doi :10.1074/jbc.M301106200 PMID 12719432 . Dawson PA, Hubbert M, Haywood J, et al. (2005). "The Heteromeric Organic Solute Transporter α-β, Ostα-Ostβ, Is an Ileal Basolateral Bile Acid Transporter" . J. Biol. Chem . 280 (8): 6960–8. doi :10.1074/jbc.M412752200 PMC 1224727 PMID 15563450 . Lee H, Zhang Y, Lee FY, et al. (2006). "FXR regulates organic solute transporters alpha and beta in the adrenal gland, kidney, and intestine" . J. Lipid Res . 47 (1): 201–14. doi :10.1194/jlr.M500417-JLR200 PMID 16251721 . Landrier JF, Eloranta JJ, Vavricka SR, Kullak-Ublick GA (2006). "The nuclear receptor for bile acids, FXR, transactivates human organic solute transporter-alpha and -beta genes". Am. J. Physiol. Gastrointest. Liver Physiol . 290 (3): G476–85. doi :10.1152/ajpgi.00430.2005 . PMID 16269519 . Ballatori N, Christian WV, Lee JY, et al. (2005). "OSTalpha-OSTbeta: a major basolateral bile acid and steroid transporter in human intestinal, renal, and biliary epithelia" . Hepatology . 42 (6): 1270–9. doi :10.1002/hep.20961 PMID 16317684 . S2CID 55829915 . Boyer JL, Trauner M, Mennone A, et al. (2006). "Upregulation of a basolateral FXR-dependent bile acid efflux transporter OSTalpha-OSTbeta in cholestasis in humans and rodents". Am. J. Physiol. Gastrointest. Liver Physiol . 290 (6): G1124–30. doi :10.1152/ajpgi.00539.2005 . PMID 16423920 . Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration" . Cell . 125 (4): 801–14. doi :10.1016/j.cell.2006.03.032 PMID 16713569 . S2CID 13709685 . Sun AQ, Balasubramaniyan N, Xu K, et al. (2007). "Protein-protein interactions and membrane localization of the human organic solute transporter". Am. J. Physiol. Gastrointest. Liver Physiol . 292 (6): G1586–93. doi :10.1152/ajpgi.00457.2006 . PMID 17332473 .
