네오제닌 은 사람에게서 NEO1 [5] [6] 단백질 이다.
상호 작용 NEO1은 PTK2 와 [7] 것 으로 나타났습니다. 또, RGMa(반발적 유도 분자 a) 결합에 의한 골격 세포 융합을 결정하는 기구의 성분으로서 네오게닌 수용체를 지목한다. [8]
레퍼런스 ^ a b c GRCh38: 앙상블 릴리즈 89: ENSG000067141 - 앙상블 , 2017년 5월^ a b c GRCm38: 앙상블 릴리즈 89: ENSMUSG000032340 - 앙상블 , 2017년 5월^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Meyerhardt JA, Look AT, Bigner SH, Fearon ER (Apr 1997). "Identification and characterization of neogenin, a DCC-related gene" . Oncogene . 14 (10): 1129–36. doi :10.1038/sj.onc.1200935 PMID 9121761 . ^ "Entrez Gene: NEO1 neogenin homolog 1 (chicken)" .^ Ren XR, Ming GL, Xie Y, Hong Y, Sun DM, Zhao ZQ, Feng Z, Wang Q, Shim S, Chen ZF, Song HJ, Mei L, Xiong WC (Nov 2004). "Focal adhesion kinase in netrin-1 signaling". Nat. Neurosci . 7 (11): 1204–12. doi :10.1038/nn1330 . PMID 15494733 . S2CID 2901216 . ^ Do Carmo Costa, Alinne; Copola, Aline Gonçalves Lio; Carvalho e Souza, Clara; Nogueira, Júlia Meireles; Silva, Gerluza Aparecida Borges; Jorge, Erika Cristina (2021). "RGMa can induce skeletal muscle cell hyperplasia via association with neogenin signalling pathway" . In Vitro Cellular & Developmental Biology - Animal . 57 (4): 415–427. doi :10.1007/s11626-021-00555-9 . PMID 33748906 . S2CID 232311370 .
추가 정보 Vielmetter J, Kayyem JF, Roman JM, Dreyer WJ (1995). "Neogenin, an avian cell surface protein expressed during terminal neuronal differentiation, is closely related to the human tumor suppressor molecule deleted in colorectal cancer" . J. Cell Biol . 127 (6 Pt 2): 2009–20. doi :10.1083/jcb.127.6.2009 . PMC 2120299 PMID 7806578 . Keino-Masu K, Masu M, Hinck L, Leonardo ED, Chan SS, Culotti JG, Tessier-Lavigne M (1996). "Deleted in Colorectal Cancer (DCC) encodes a netrin receptor" . Cell . 87 (2): 175–85. doi :10.1016/S0092-8674(00)81336-7 PMID 8861902 . Vielmetter J, Chen XN, Miskevich F, Lane RP, Yamakawa K, Korenberg JR, Dreyer WJ (1997). "Molecular characterization of human neogenin, a DCC-related protein, and the mapping of its gene (NEO1) to chromosomal position 15q22.3-q23". Genomics . 41 (3): 414–21. doi :10.1006/geno.1997.4688 . PMID 9169140 . Wang H, Copeland NG, Gilbert DJ, Jenkins NA, Tessier-Lavigne M (1999). "Netrin-3, a mouse homolog of human NTN2L, is highly expressed in sensory ganglia and shows differential binding to netrin receptors" . J. Neurosci . 19 (12): 4938–47. doi :10.1523/JNEUROSCI.19-12-04938.1999 PMC 6782680 PMID 10366627 . Srinivasan K, Strickland P, Valdes A, Shin GC, Hinck L (2003). "Netrin-1/neogenin interaction stabilizes multipotent progenitor cap cells during mammary gland morphogenesis" . Dev. Cell . 4 (3): 371–82. doi :10.1016/S1534-5807(03)00054-6 PMID 12636918 . Ho SM, Lau KM, Mok SC, Syed V (2003). "Profiling follicle stimulating hormone-induced gene expression changes in normal and malignant human ovarian surface epithelial cells" . Oncogene . 22 (27): 4243–56. doi :10.1038/sj.onc.1206437 PMID 12833147 . Matsunaga E, Tauszig-Delamasure S, Monnier PP, Mueller BK, Strittmatter SM, Mehlen P, Chédotal A (2004). "RGM and its receptor neogenin regulate neuronal survival". Nat. Cell Biol . 6 (8): 749–55. doi :10.1038/ncb1157 . PMID 15258591 . S2CID 15433313 . Ren XR, Ming GL, Xie Y, Hong Y, Sun DM, Zhao ZQ, Feng Z, Wang Q, Shim S, Chen ZF, Song HJ, Mei L, Xiong WC (2005). "Focal adhesion kinase in netrin-1 signaling". Nat. Neurosci . 7 (11): 1204–12. doi :10.1038/nn1330 . PMID 15494733 . S2CID 2901216 . Lee JE, Kim HJ, Bae JY, Kim SW, Park JS, Shin HJ, Han W, Kim SW, Kang KS, Noh DY (2006). "Neogenin expression may be inversely correlated to the tumorigenicity of human breast cancer" . BMC Cancer . 5 : 154. doi :10.1186/1471-2407-5-154 . PMC 1322231 PMID 16324219 . Liu T, Qian WJ, Gritsenko MA, Camp DG, Monroe ME, Moore RJ, Smith RD (2006). "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry" . J. Proteome Res . 4 (6): 2070–80. doi :10.1021/pr0502065 . PMC 1850943 PMID 16335952 .
PDB 갤러리
1x5f : 인간 네오제닌의 제1피브로넥틴 타입 III 도메인의 용액 구조
1x5g : 인간 네오제닌의 제2 피브로넥틴 타입 III 도메인의 용액 구조
1x5h : 인간 네오제닌의 세 번째 피브로넥틴 타입 III 도메인의 용액 구조
1x5i : 인간 네오제닌의 제4 피브로넥틴 타입 III 도메인의 용액 구조
1x5j : 인간 네오제닌의 5번째 피브로넥틴 타입 III 도메인의 용액 구조
1x5k : 인간 네오제닌의 6번째 피브로넥틴 타입 III 도메인의 용액 구조
