MAD2L2
MAD2L2
미토틱 스핀들 조립체 검사점 단백질 MAD2B는 인간에서 MAD2L2 유전자에 의해 인코딩되는 단백질이다.[5][6]
함수
MAD2L2는 모든 염색체가 은유효소 판에서 적절하게 정렬될 때까지 아나파제의 시작을 막는 유사성 스핀들 조립체 검문소의 구성요소다.MAD2L2는 MAD2L1의 호몰로어다.[6]
상호작용
MAD2L2는 다음과 상호 작용하는 것으로 나타났다.
참조
- ^ a b c GRCh38: 앙상블 릴리스 89: ENSG00000116670 - 앙상블, 2017년 5월
- ^ a b c GRCm38: 앙상블 릴리스 89: ENSMUSG000029003 - 앙상블, 2017년 5월
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Cahill DP, da Costa LT, Carson-Walter EB, Kinzler KW, Vogelstein B, Lengauer C (Aug 1999). "Characterization of MAD2B and other mitotic spindle checkpoint genes". Genomics. 58 (2): 181–187. doi:10.1006/geno.1999.5831. PMID 10366450.
- ^ a b "Entrez Gene: MAD2L2 MAD2 mitotic arrest deficient-like 2 (yeast)".
- ^ Nelson KK, Schlöndorff J, Blobel CP (Nov 1999). "Evidence for an interaction of the metalloprotease-disintegrin tumour necrosis factor alpha convertase (TACE) with mitotic arrest deficient 2 (MAD2), and of the metalloprotease-disintegrin MDC9 with a novel MAD2-related protein, MAD2beta". Biochem. J. 343. 343 (3): 673–680. doi:10.1042/0264-6021:3430673. PMC 1220601. PMID 10527948.
- ^ a b Murakumo Y, Roth T, Ishii H, Rasio D, Numata S, Croce CM, Fishel R (Feb 2000). "A human REV7 homolog that interacts with the polymerase zeta catalytic subunit hREV3 and the spindle assembly checkpoint protein hMAD2". J. Biol. Chem. 275 (6): 4391–4397. doi:10.1074/jbc.275.6.4391. PMID 10660610.
- ^ a b Murakumo Y, Ogura Y, Ishii H, Numata S, Ichihara M, Croce CM, Fishel R, Takahashi M (Sep 2001). "Interactions in the error-prone postreplication repair proteins hREV1, hREV3, and hREV7". J. Biol. Chem. 276 (38): 35644–35651. doi:10.1074/jbc.M102051200. PMID 11485998.
추가 읽기
- Nelson KK, Schlöndorff J, Blobel CP (1999). "Evidence for an interaction of the metalloprotease-disintegrin tumour necrosis factor alpha convertase (TACE) with mitotic arrest deficient 2 (MAD2), and of the metalloprotease-disintegrin MDC9 with a novel MAD2-related protein, MAD2beta". Biochem. J. 343. 343 (3): 673–680. doi:10.1042/0264-6021:3430673. PMC 1220601. PMID 10527948.
- Murakumo Y, Roth T, Ishii H, Rasio D, Numata S, Croce CM, Fishel R (2000). "A human REV7 homolog that interacts with the polymerase zeta catalytic subunit hREV3 and the spindle assembly checkpoint protein hMAD2". J. Biol. Chem. 275 (6): 4391–4397. doi:10.1074/jbc.275.6.4391. PMID 10660610.
- Chan SH, Hung FS, Chan DS, Shaw PC (2001). "Trichosanthin interacts with acidic ribosomal proteins P0 and P1 and mitotic checkpoint protein MAD2B". Eur. J. Biochem. 268 (7): 2107–2112. doi:10.1046/j.1432-1327.2001.02091.x. PMID 11277934.
- Chen J, Fang G (2001). "MAD2B is an inhibitor of the anaphase-promoting complex". Genes Dev. 15 (14): 1765–1770. doi:10.1101/gad.898701. PMC 312737. PMID 11459826.
- Murakumo Y, Ogura Y, Ishii H, Numata S, Ichihara M, Croce CM, Fishel R, Takahashi M (2001). "Interactions in the error-prone postreplication repair proteins hREV1, hREV3, and hREV7". J. Biol. Chem. 276 (38): 35644–35651. doi:10.1074/jbc.M102051200. PMID 11485998.
- Weterman MA, van Groningen JJ, Tertoolen L, van Kessel AG (2001). "Impairment of MAD2B-PRCC interaction in mitotic checkpoint defective t(X;1)-positive renal cell carcinomas". Proc. Natl. Acad. Sci. U.S.A. 98 (24): 13808–13813. Bibcode:2001PNAS...9813808W. doi:10.1073/pnas.241304198. PMC 61123. PMID 11717438.
- Masuda Y, Ohmae M, Masuda K, Kamiya K (2003). "Structure and enzymatic properties of a stable complex of the human REV1 and REV7 proteins". J. Biol. Chem. 278 (14): 12356–12360. doi:10.1074/jbc.M211765200. PMID 12529368.
- Ying B, Wold WS (2003). "Adenovirus ADP protein (E3–11.6K), which is required for efficient cell lysis and virus release, interacts with human MAD2B". Virology. 313 (1): 224–234. doi:10.1016/S0042-6822(03)00287-3. PMID 12951035.
- Lehner B, Semple JI, Brown SE, Counsell D, Campbell RD, Sanderson CM (2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region". Genomics. 83 (1): 153–167. doi:10.1016/S0888-7543(03)00235-0. PMID 14667819.
- Ohashi E, Murakumo Y, Kanjo N, Akagi J, Masutani C, Hanaoka F, Ohmori H (2004). "Interaction of hREV1 with three human Y-family DNA polymerases". Genes Cells. 9 (6): 523–531. doi:10.1111/j.1356-9597.2004.00747.x. PMID 15189446.
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- Rimkus C, Friederichs J, Rosenberg R, Holzmann B, Siewert JR, Janssen KP (2007). "Expression of the mitotic checkpoint gene MAD2L2 has prognostic significance in colon cancer". Int. J. Cancer. 120 (1): 207–211. doi:10.1002/ijc.22155. PMID 17044027.
- Zhang L, Yang SH, Sharrocks AD (2007). "Rev7/MAD2B links c-Jun N-terminal protein kinase pathway signaling to activation of the transcription factor Elk-1". Mol. Cell. Biol. 27 (8): 2861–2869. doi:10.1128/MCB.02276-06. PMC 1899940. PMID 17296730.
- Pinto M, Soares MJ, Cerveira N, Henrique R, Ribeiro FR, Oliveira J, Jerónimo C, Teixeira MR (2007). "Expression changes of the MAD mitotic checkpoint gene family in renal cell carcinomas characterized by numerical chromosome changes". Virchows Arch. 450 (4): 379–385. doi:10.1007/s00428-007-0386-7. PMID 17333263. S2CID 36088468.
