Layilin은 인간에서 LAYN [5]유전자에 의해 암호화되는 단백질이다.
의료 관련성
연구에 따르면 Layilin은 간암 [6]환자의 CD8+ 세포독성 T세포에 침투하는 종양에서 상향 조절된다.
레퍼런스
- ^ a b c GRCh38: 앙상블 릴리즈 89: ENSG00000204381 - 앙상블, 2017년 5월
- ^ a b c GRCm38: 앙상블 릴리즈 89: ENSMUSG000060594 - 앙상블, 2017년 5월
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: Layilin".
- ^ Zheng C, Zheng L, Yoo JK, Guo H, Zhang Y, Guo X, Kang B, Hu R, Huang JY, Zhang Q, Liu Z, Dong M, Hu X, Ouyang W, Peng J, Zhang Z (2017). "Landscape of Infiltrating T Cells in Liver Cancer Revealed by Single-Cell Sequencing". Cell. 169 (7): 1342–1356.e16. doi:10.1016/j.cell.2017.05.035. PMID 28622514.
추가 정보
- Bono P, Rubin K, Higgins JM, Hynes RO (2001). "Layilin, a novel integral membrane protein, is a hyaluronan receptor". Mol. Biol. Cell. 12 (4): 891–900. doi:10.1091/mbc.12.4.891. PMC 32274. PMID 11294894.
- Borowsky ML, Hynes RO (1998). "Layilin, a novel talin-binding transmembrane protein homologous with C-type lectins, is localized in membrane ruffles". J. Cell Biol. 143 (2): 429–42. doi:10.1083/jcb.143.2.429. PMC 2132847. PMID 9786953.
- Forteza RM, Casalino-Matsuda SM, Falcon NS, Valencia Gattas M, Monzon ME (2012). "Hyaluronan and layilin mediate loss of airway epithelial barrier function induced by cigarette smoke by decreasing E-cadherin". J. Biol. Chem. 287 (50): 42288–98. doi:10.1074/jbc.M112.387795. PMC 3516772. PMID 23048036.
- Bono P, Cordero E, Johnson K, Borowsky M, Ramesh V, Jacks T, Hynes RO (2005). "Layilin, a cell surface hyaluronan receptor, interacts with merlin and radixin". Exp. Cell Res. 308 (1): 177–87. doi:10.1016/j.yexcr.2005.04.017. PMID 15913605.
