열 반복

HEAT repeat
열 반복
Alpha solenoid pp2a 2iae with single repeat center.png
15개의 HEAT 반복으로 구성된 알파 솔레노이드 구조의 예.단백질인산효소 2A 규제 하위 단위는 N-terminus가 아래쪽에 파란색으로 표시되고 C-terminus가 위쪽에 빨간색으로 표시된다.중앙에는 바깥쪽 나선은 분홍색으로, 안쪽 나선은 녹색으로, 턴은 흰색으로 한 개의 나선형 모티브가 그려져 있다.PDB: 2IAE에서.[1][2]
식별자
기호열
PfamPF02985
인터프로IPR000357
프로사이트PDOC50077
SCOP21b3u / SCOPe / SUPFAM

HEAT repeat는 짧은 루프로 연결된 두 개의 알파 나선형으로 구성된 단백질 탠덤 반복 구조 모티브다.Heat repeats는 다수의 세포질 단백질에서 발견되는 솔레노이드 단백질 영역의 한 유형인 알파 솔레노이드를 형성할 수 있다."HEAT"라는 이름은 이 반복 구조가 발견되는 네 가지 단백질의 약자다.Huntingtin, 신장 인자 3 (EF3), 단백질 인산염 2A (PP2A),[3] 효모 키나아제 TOR1.[4] HIT 반복은 세포 내 이동에 종종 관여하는 확장 초신성 구조를 형성하며, 이들은 구조적으로 아르마딜로 반복과 관련이 있다.핵 운반 단백질 가져오기 베타에는 19개의 HEAT 반복측정기가 포함되어 있다.

다양한 HIT는 단백질과 그 구조를 반복한다.

대전차 고성능 유탄 반복 단백질의 대표적인 예 condensin과 cohesin,[6]separase,[7]PIKKs의 ATM(어택 시어 telangiectasia mutated)과 여객(어택 시어 telangiectasia과 Rad3 관련)[8][9]고 microtubul 같은 importinβ(또한 karyopherin로 β 알려진)family,[5]규제 서브 유닛(phosphatidylinositol3-kinase-related 단백질 kinases)을 포함한다.prote e-bindingXMAP215/Dis1/TOG[10] 및 CLASP.[11]따라서, HIT 반복 단백질의 세포 기능은 매우 가변적이다.

다음의 HIAT 반복 단백질의 구조는 지금까지 결정되었다.

참조

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