GOPC 사용 가능한 구조 PDB Ortholog 검색: PDBe RCSB PDB ID 코드 목록 2DC2 , 2LOB, 4E34 , 4E35 , 4JOE, 4JOG , 4JOH , 4JOJ , 4JOK, 4JOP , 4JOR , 4K6Y , 4K72 , 4K75 , 4K76 , 4K78 , 4MPN
식별자 에일리어스 GOPC 외부 ID OMIM : 606845 MGI : 2149946 HomoloGene : 10695 GenCard : GOPC 맞춤법 종. 인간 마우스 엔트레즈 앙상블 유니프로트 RefSeq(mRNA) RefSeq(단백질) 장소(UCSC) Chr 6: 117.56 ~117.6 Mb Chr 10: 52.21 ~52.26 Mb PubMed 검색[3] [4] 위키데이터
골지 관련 PDZ 및 코일 코일 모티브 함유 단백질은 GOPC [5] [6] [7] 유전자 에 의해 인체 내에서 부호화되는 단백질 이다.
PIST는 PDZ 도메인을 포함한 골지 단백질이다. PDZ 도메인은 약 90개의 아미노산을 포함하고 배열 특이적인 방식으로 단백질의 극한 C 말단을 결합한다. [OMIM [7]
상호 작용 GOPC는 GRID2 ,[8] BECN1 ,[8] RHOQ ,[5] ACCN3 ,[9] 낭포성 섬유화 경막 전도도 [10] [11] CSPG5 와 [12] 것 으로 나타났다.
레퍼런스 ^ a b c GRCh38: 앙상블 릴리즈 89: ENSG000047932 - 앙상블 , 2017년 5월^ a b c GRCm38: 앙상블 릴리즈 89: ENSMUSG000019861 - 앙상블 , 2017년 5월^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ a b Neudauer CL, Joberty G, Macara IG (Feb 2001). "PIST: a novel PDZ/coiled-coil domain binding partner for the rho-family GTPase TC10". Biochem Biophys Res Commun . 280 (2): 541–7. doi :10.1006/bbrc.2000.4160 . PMID 11162552 . ^ Yao R, Maeda T, Takada S, Noda T (Aug 2001). "Identification of a PDZ domain containing Golgi protein, GOPC, as an interaction partner of frizzled". Biochem Biophys Res Commun . 286 (4): 771–8. doi :10.1006/bbrc.2001.5430 . PMID 11520064 . ^ a b "Entrez Gene: GOPC golgi associated PDZ and coiled-coil motif containing" .^ a b Yue, Zhenyu; Horton Antony; Bravin Monica; DeJager Philip L; Selimi Fekrije; Heintz Nathaniel (Aug 2002). "A novel protein complex linking the delta 2 glutamate receptor and autophagy: implications for neurodegeneration in lurcher mice" . Neuron . United States. 35 (5): 921–33. doi :10.1016/S0896-6273(02)00861-9 ISSN 0896-6273 . PMID 12372286 . S2CID 10534933 . ^ Hruska-Hageman, Alesia M; Benson Christopher J; Leonard A Soren; Price Margaret P; Welsh Michael J (Nov 2004). "PSD-95 and Lin-7b interact with acid-sensing ion channel-3 and have opposite effects on H+- gated current" . J. Biol. Chem . United States. 279 (45): 46962–8. doi :10.1074/jbc.M405874200 ISSN 0021-9258 . PMID 15317815 . ^ Cheng, Jie; Moyer Bryan D; Milewski Michal; Loffing Johannes; Ikeda Masahiro; Mickle John E; Cutting Garry R; Li Min; Stanton Bruce A; Guggino William B (Feb 2002). "A Golgi-associated PDZ domain protein modulates cystic fibrosis transmembrane regulator plasma membrane expression" . J. Biol. Chem . United States. 277 (5): 3520–9. doi :10.1074/jbc.M110177200 ISSN 0021-9258 . PMID 11707463 . ^ Gentzsch, Martina; Cui Liying; Mengos April; Chang Xiu-Bao; Chen Jey-Hsin; Riordan John R (Feb 2003). "The PDZ-binding chloride channel ClC-3B localizes to the Golgi and associates with cystic fibrosis transmembrane conductance regulator-interacting PDZ proteins" . J. Biol. Chem . United States. 278 (8): 6440–9. doi :10.1074/jbc.M211050200 ISSN 0021-9258 . PMID 12471024 . ^ Hassel, Burkhard; Schreff Matthias; Stube Eva-Maria; Blaich Uta; Schumacher Stefan (Oct 2003). "CALEB/NGC interacts with the Golgi-associated protein PIST" . J. Biol. Chem . United States. 278 (41): 40136–43. doi :10.1074/jbc.M305577200 ISSN 0021-9258 . PMID 12885772 .
추가 정보 Loo MA, Jensen TJ, Cui L, et al. (1999). "Perturbation of Hsp90 interaction with nascent CFTR prevents its maturation and accelerates its degradation by the proteasome" . EMBO J . 17 (23): 6879–87. doi :10.1093/emboj/17.23.6879 . PMC 1171036 PMID 9843494 . Charest A, Lane K, McMahon K, Housman DE (2001). "Association of a novel PDZ domain-containing peripheral Golgi protein with the Q-SNARE (Q-soluble N-ethylmaleimide-sensitive fusion protein (NSF) attachment protein receptor) protein syntaxin 6" . J. Biol. Chem . 276 (31): 29456–65. doi :10.1074/jbc.M104137200 PMID 11384996 . Cheng J, Moyer BD, Milewski M, et al. (2002). "A Golgi-associated PDZ domain protein modulates cystic fibrosis transmembrane regulator plasma membrane expression" . J. Biol. Chem . 277 (5): 3520–9. doi :10.1074/jbc.M110177200 PMID 11707463 . Yao R, Ito C, Natsume Y, et al. (2002). "Lack of acrosome formation in mice lacking a Golgi protein, GOPC" . Proc. Natl. Acad. Sci. U.S.A . 99 (17): 11211–6. Bibcode :2002PNAS...9911211Y . doi :10.1073/pnas.162027899 PMC 123235 PMID 12149515 . Yue Z, Horton A, Bravin M, et al. (2002). "A novel protein complex linking the delta 2 glutamate receptor and autophagy: implications for neurodegeneration in lurcher mice" . Neuron . 35 (5): 921–33. doi :10.1016/S0896-6273(02)00861-9 PMID 12372286 . S2CID 10534933 . Gentzsch M, Cui L, Mengos A, et al. (2003). "The PDZ-binding chloride channel ClC-3B localizes to the Golgi and associates with cystic fibrosis transmembrane conductance regulator-interacting PDZ proteins" . J. Biol. Chem . 278 (8): 6440–9. doi :10.1074/jbc.M211050200 PMID 12471024 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Charest A, Kheifets V, Park J, et al. (2003). "Oncogenic targeting of an activated tyrosine kinase to the Golgi apparatus in a glioblastoma" . Proc. Natl. Acad. Sci. U.S.A . 100 (3): 916–21. Bibcode :2003PNAS..100..916C . doi :10.1073/pnas.242741799 PMC 298701 PMID 12538861 . Charest A, Lane K, McMahon K, et al. (2003). "Fusion of FIG to the receptor tyrosine kinase ROS in a glioblastoma with an interstitial del(6)(q21q21)". Genes Chromosomes Cancer . 37 (1): 58–71. doi :10.1002/gcc.10207 . PMID 12661006 . S2CID 39776967 . Hassel B, Schreff M, Stube EM, et al. (2003). "CALEB/NGC interacts with the Golgi-associated protein PIST" . J. Biol. Chem . 278 (41): 40136–43. doi :10.1074/jbc.M305577200 PMID 12885772 . Cheng J, Wang H, Guggino WB (2004). "Modulation of mature cystic fibrosis transmembrane regulator protein by the PDZ domain protein CAL" . J. Biol. Chem . 279 (3): 1892–8. doi :10.1074/jbc.M308640200 PMID 14570915 . Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6" . Nature . 425 (6960): 805–11. Bibcode :2003Natur.425..805M . doi :10.1038/nature02055 PMID 14574404 . Brill LM, Salomon AR, Ficarro SB, et al. (2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry". Anal. Chem . 76 (10): 2763–72. doi :10.1021/ac035352d . PMID 15144186 . Hruska-Hageman AM, Benson CJ, Leonard AS, et al. (2004). "PSD-95 and Lin-7b interact with acid-sensing ion channel-3 and have opposite effects on H+- gated current" . J. Biol. Chem . 279 (45): 46962–8. doi :10.1074/jbc.M405874200 PMID 15317815 . He J, Bellini M, Xu J, et al. (2005). "Interaction with cystic fibrosis transmembrane conductance regulator-associated ligand (CAL) inhibits beta1-adrenergic receptor surface expression" . J. Biol. Chem . 279 (48): 50190–6. doi :10.1074/jbc.M404876200 PMID 15358775 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Cheng J, Wang H, Guggino WB (2005). "Regulation of cystic fibrosis transmembrane regulator trafficking and protein expression by a Rho family small GTPase TC10" . J. Biol. Chem . 280 (5): 3731–9. doi :10.1074/jbc.M410026200 PMID 15546864 . Hicks SW, Machamer CE (2005). "Isoform-specific interaction of golgin-160 with the Golgi-associated protein PIST" . J. Biol. Chem . 280 (32): 28944–51. doi :10.1074/jbc.M504937200 PMID 15951434 .
