호모 사피엔스 종의 단백질 코드 유전자
GGA1 사용 가능한 구조 PDB Ortholog 검색: PDBe RCSB PDB ID 코드 목록 1J2J , 1JWF, 1JWG, 1NA8 , 1NAF , 1NWM , 1OXX , 1OM9 , 1OXZ , 1PY1 , 1UJJJ , 1UJK , 1X79, 2DW2, 3YG
식별자 에일리어스 GGA1 외부 ID OMIM : 606004 MGI : 2146207 HomoloGene : 39250 GenCard: GGA1 맞춤법 종. 인간 마우스 엔트레즈 앙상블 유니프로트 RefSeq(mRNA) RefSeq(단백질) 장소(UCSC) Chr 22: 37.61 ~37.63 Mb Chr 15: 78.76 ~78.78 Mb PubMed 검색[3] [4] 위키데이터
ADP-리보실화인자결합단백질 GGA1 은 GGA1 [5] [6] [7] 단백질 이다.
이 유전자는 골지 국소화 감마 어댑틴 귀 함유 ARF 결합(GGA) 단백질 패밀리 멤버를 코드한다. 이 과의 구성원들은 골기 통과 네트워크와 리소좀 사이의 단백질의 이동을 조절하는 유비쿼터스 코트 단백질이다. 이러한 단백질은 아미노 말단 VHS 도메인 을 공유하여 Golgi 네트워크에서 만노스 6-인산 수용체의 분류를 매개한다. 그들은 또한 감마 아답틴의 귀 도메인과 상동성을 갖는 카르복시 말단 영역을 포함한다. 이 [8]
상호 작용 GGA1은 Sortilin [9] BACE2 ,[10] RABEP1 [11] ARF3 와 [12] [13] 상호작용 하는 것으로 나타났습니다 .
레퍼런스 ^ a b c GRCh38: 앙상블 릴리즈 89: ENSG00000100083 - 앙상블 , 2017년 5월^ a b c GRCm38: 앙상블 릴리즈 89: ENSMUSG000033128 - 앙상블 , 2017년 5월^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Hirst J, Lui WW, Bright NA, Totty N, Seaman MN, Robinson MS (May 2000). "A family of proteins with gamma-adaptin and VHS domains that facilitate trafficking between the trans-Golgi network and the vacuole/lysosome" . J Cell Biol . 149 (1): 67–80. doi :10.1083/jcb.149.1.67 . PMC 2175106 PMID 10747088 . ^ Dell'Angelica EC, Puertollano R, Mullins C, Aguilar RC, Vargas JD, Hartnell LM, Bonifacino JS (May 2000). "GGAs: a family of ADP ribosylation factor-binding proteins related to adaptors and associated with the Golgi complex" . J Cell Biol . 149 (1): 81–94. doi :10.1083/jcb.149.1.81 . PMC 2175099 PMID 10747089 . ^ Xie L, Boyle D, Sanford D, Scherer PE, Pessin JE, Mora S (March 2006). "Intracellular trafficking and secretion of adiponectin is dependent on GGA-coated vesicles" . J Biol Chem . 281 (11): 7253–9. doi :10.1074/jbc.M511313200 PMID 16407204 . ^ "Entrez Gene: GGA1 golgi associated, gamma adaptin ear containing, ARF binding protein 1" .^ Jacobsen, Linda; Madsen Peder; Nielsen Morten S; Geraerts Wijnand P M; Gliemann Jørgen; Smit August B; Petersen Claus M (January 2002). "The sorLA cytoplasmic domain interacts with GGA1 and -2 and defines minimum requirements for GGA binding". FEBS Lett . 511 (1–3): 155–8. doi :10.1016/S0014-5793(01)03299-9 . ISSN 0014-5793 . PMID 11821067 . S2CID 21977507 . ^ He, Xiangyuan; Chang Wan-Pin; Koelsch Gerald; Tang Jordan (July 2002). "Memapsin 2 (beta-secretase) cytosolic domain binds to the VHS domains of GGA1 and GGA2: implications on the endocytosis mechanism of memapsin 2" . FEBS Lett . 524 (1–3): 183–7. doi :10.1016/S0014-5793(02)03052-1 ISSN 0014-5793 . PMID 12135764 . ^ Mattera, Rafael; Arighi Cecilia N; Lodge Robert; Zerial Marino; Bonifacino Juan S (January 2003). "Divalent interaction of the GGAs with the Rabaptin-5-Rabex-5 complex" . EMBO J . 22 (1): 78–88. doi :10.1093/emboj/cdg015 . ISSN 0261-4189 . PMC 140067 PMID 12505986 . ^ Boman, Annette L; Salo Paul D; Hauglund Melissa J; Strand Nicole L; Rensink Shelly J; Zhdankina Olga (September 2002). "ADP-ribosylation factor (ARF) interaction is not sufficient for yeast GGA protein function or localization" . Mol. Biol. Cell . 13 (9): 3078–95. doi :10.1091/mbc.E02-02-0078 . ISSN 1059-1524 . PMC 124144 PMID 12221117 . ^ Boman, A L; Zhang C j; Zhu X; Kahn R A (April 2000). "A family of ADP-ribosylation factor effectors that can alter membrane transport through the trans-Golgi" . Mol. Biol. Cell . 11 (4): 1241–55. doi :10.1091/mbc.11.4.1241 . ISSN 1059-1524 . PMC 14844 PMID 10749927 .
추가 정보 Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene . 138 (1–2): 171–4. doi :10.1016/0378-1119(94)90802-8 . PMID 8125298 . Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene . 200 (1–2): 149–56. doi :10.1016/S0378-1119(97)00411-3 . PMID 9373149 . Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22" . Nature . 402 (6761): 489–95. Bibcode :1999Natur.402..489D . doi :10.1038/990031 PMID 10591208 . Boman AL, Zhang C, Zhu X, Kahn RA (2000). "A family of ADP-ribosylation factor effectors that can alter membrane transport through the trans-Golgi" . Mol. Biol. Cell . 11 (4): 1241–55. doi :10.1091/mbc.11.4.1241 . PMC 14844 PMID 10749927 . Takatsu H, Yoshino K, Nakayama K (2000). "Adaptor gamma ear homology domain conserved in gamma-adaptin and GGA proteins that interact with gamma-synergin". Biochem. Biophys. Res. Commun . 271 (3): 719–25. doi :10.1006/bbrc.2000.2700 . PMID 10814529 . Zhdankina O, Strand NL, Redmond JM, Boman AL (2001). "Yeast GGA proteins interact with GTP-bound Arf and facilitate transport through the Golgi". Yeast . 18 (1): 1–18. doi :10.1002/1097-0061(200101)18:1<1::AID-YEA644>3.0.CO;2-5 . PMID 11124697 . Puertollano R, Randazzo PA, Presley JF, et al. (2001). "The GGAs promote ARF-dependent recruitment of clathrin to the TGN" . Cell . 105 (1): 93–102. doi :10.1016/S0092-8674(01)00299-9 PMID 11301005 . Puertollano R, Aguilar RC, Gorshkova I, et al. (2001). "Sorting of mannose 6-phosphate receptors mediated by the GGAs". Science . 292 (5522): 1712–6. Bibcode :2001Sci...292.1712P . doi :10.1126/science.1060750 . PMID 11387475 . S2CID 30836125 . Takatsu H, Katoh Y, Shiba Y, Nakayama K (2001). "Golgi-localizing, gamma-adaptin ear homology domain, ADP-ribosylation factor-binding (GGA) proteins interact with acidic dileucine sequences within the cytoplasmic domains of sorting receptors through their Vps27p/Hrs/STAM (VHS) domains" . J. Biol. Chem . 276 (30): 28541–5. doi :10.1074/jbc.C100218200 PMID 11390366 . Jacobsen L, Madsen P, Nielsen MS, et al. (2002). "The sorLA cytoplasmic domain interacts with GGA1 and -2 and defines minimum requirements for GGA binding". FEBS Lett . 511 (1–3): 155–8. doi :10.1016/S0014-5793(01)03299-9 . PMID 11821067 . S2CID 21977507 . Shiba T, Takatsu H, Nogi T, et al. (2002). "Structural basis for recognition of acidic-cluster dileucine sequence by GGA1". Nature . 415 (6874): 937–41. Bibcode :2002Natur.415..937S . doi :10.1038/415937a . PMID 11859376 . S2CID 4395774 . Takatsu H, Yoshino K, Toda K, Nakayama K (2002). "GGA proteins associate with Golgi membranes through interaction between their GGAH domains and ADP-ribosylation factors" . Biochem. J . 365 (Pt 2): 369–78. doi :10.1042/BJ20020428 . PMC 1222692 PMID 11950392 . Doray B, Bruns K, Ghosh P, Kornfeld SA (2002). "Autoinhibition of the ligand-binding site of GGA1/3 VHS domains by an internal acidic cluster-dileucine motif" . Proc. Natl. Acad. Sci. U.S.A . 99 (12): 8072–7. Bibcode :2002PNAS...99.8072D . doi :10.1073/pnas.082235699 PMC 123022 PMID 12060753 . He X, Chang WP, Koelsch G, Tang J (2002). "Memapsin 2 (beta-secretase) cytosolic domain binds to the VHS domains of GGA1 and GGA2: implications on the endocytosis mechanism of memapsin 2" . FEBS Lett . 524 (1–3): 183–7. doi :10.1016/S0014-5793(02)03052-1 PMID 12135764 . Boman AL, Salo PD, Hauglund MJ, et al. (2003). "ADP-ribosylation factor (ARF) interaction is not sufficient for yeast GGA protein function or localization" . Mol. Biol. Cell . 13 (9): 3078–95. doi :10.1091/mbc.E02-02-0078 . PMC 124144 PMID 12221117 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Mattera R, Arighi CN, Lodge R, et al. (2003). "Divalent interaction of the GGAs with the Rabaptin-5-Rabex-5 complex" . EMBO J . 22 (1): 78–88. doi :10.1093/emboj/cdg015 . PMC 140067 PMID 12505986 . Mills IG, Praefcke GJ, Vallis Y, et al. (2003). "EpsinR: an AP1/clathrin interacting protein involved in vesicle trafficking" . J. Cell Biol . 160 (2): 213–22. doi :10.1083/jcb.200208023 . PMC 2172650 PMID 12538641 .
PDB 갤러리
1j2j : ARF1 GTP 형태와 복합체 GGA1 GAT N-말단 영역의 결정 구조
1jwf : 인간 GGA1 VHS 도메인의 결정 구조.
1jwg : 양이온 비의존 M6PR C-말단 펩타이드와 복합된 인간 GGA1의 VHS 도메인
1na8 : ADP-리보실화인자결합단백질 GGA1의 결정구조
1naf : 인간 GGA1 GAT 도메인의 결정 구조
1o3x : 인간 GGA1 GAT 도메인의 결정 구조
1om9 : p56 결합펩타이드와 복합체 GGA1 부가물의 구조
1oxz : 인간 GGA1 GAT 도메인의 결정 구조
1py1 : GGA1-VHS 도메인과 β-시크리테아제 C-말단 포스포펩타이드 복합체
1ujj : BACE의 C-말단펩타이드와 복합된 인간 GGA1의 VHS 도메인
1ujk : BACE의 C-말단 포스포펩타이드와 복합된 인간 GGA1의 VHS 도메인
1x79 : 라밥틴5의 GAT 결합 도메인과 복합된 인간 GGA1 GAT 도메인의 결정 구조
2dwx : WNSF를 모티브로 한 GGA1-GAE의 공동결정구조해석
