FHOD1

FHOD1
사용 가능한 구조
PDB	휴먼 유니프로트 검색: PDBe RCSB
PDB ID 코드 목록
	3대
식별자
에일리어스	1을 포함한 FHOD1, FHOS, 포르민 호몰로지 2 도메인
외부 ID	OMIM : 606881 HomoloGene : 40860 GenCard : FHOD1
유전자 위치(인간)
크르.	16번 염색체(인간)
끝.	67,247,481 bp
RNA발현패턴
	상단 표시 위치:
	비장; ; 위근; ; 좌폐 상엽; ; 오른쪽 폐; ; 갑상선 우엽; ; 상완 삼두근; ; 갑상선 좌엽; ; 자궁내막간질세포; ; 외측 광대근; ; 상완 이두근;
	없음
	추가 참조 표현식 데이터
	추가 참조 표현식 데이터
유전자 존재론
분자 함수	액틴 결합; 단백질 결합; 동일단백질결합; 단백질 도메인 특이 결합; 단백질 자기 연관성;
셀룰러 컴포넌트	세포 투영; 삐걱거리다; 막; 핵; 세포골격; 응력 섬유; 세포질; 세포; 삽입 디스크;
생물학적 과정	응력 섬유 어셈블리의 정조절; 핵이동; 중심체 국재 확립; RNA중합효소II에 의한 전사의 양성 조절; 응력 섬유 집합체 조절;
	출처:아미고 / QuickGO
맞춤법
	29109
	없음
	ENSG00000135723
	없음
	Q9Y613
	없음
	NM_013241; NM_001318202
	없음
	NP_001305131; NP_037373
	없음
	위키데이터
인간 보기/편집

FH1/FH2 도메인 함유 단백질 1은 FHOD1 ^[3]^[4]^[5]유전자에 의해 인체 내에서 부호화되는 단백질이다.

이 유전자는 포르민/디아파누스 단백질 패밀리의 구성원인 단백질을 암호화합니다.그 유전자는 어디에나 발현되지만 비장에서 풍부하게 발견된다.암호화된 단백질은 FH(Formin Homology)1 및 FH2 도메인 내에서 간질 및 포름 단백질에 대한 배열 호몰로지를 가진다.또한 코일 코일 도메인, 콜라겐 유사 도메인, 2개의 핵 국재 신호 및 여러 잠재적 PKC 및 PKA 인산화 부위를 포함한다.그것은 주로 세포질 단백질이며 다양한 인간 ^[5]세포주로 발현된다.

상호 작용

FHOD1은 RAC1과 ^[6]상호작용하는 것으로 나타났습니다.

레퍼런스

^ ^a ^b ^c GRCh38: 앙상블 릴리즈 89: ENSG00000135723 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Westendorf JJ, Mernaugh R, Hiebert SW (May 1999). "Identification and characterization of a protein containing formin homology (FH1/FH2) domains". Gene. 232 (2): 173–82. doi:10.1016/S0378-1119(99)00127-4. PMID 10352228.
^ Boehm MB, Milius TJ, Zhou Y, Westendorf JJ, Koka S (October 2005). "The mammalian formin FHOD1 interacts with the ERK MAP kinase pathway". Biochemical and Biophysical Research Communications. 335 (4): 1090–4. doi:10.1016/j.bbrc.2005.07.191. PMID 16112087.
^ ^a ^b "Entrez Gene: FHOD1 formin homology 2 domain containing 1".
^ Westendorf JJ (December 2001). "The formin/diaphanous-related protein, FHOS, interacts with Rac1 and activates transcription from the serum response element". The Journal of Biological Chemistry. 276 (49): 46453–9. doi:10.1074/jbc.M105162200. PMID 11590143.

추가 정보

Westendorf JJ (December 2001). "The formin/diaphanous-related protein, FHOS, interacts with Rac1 and activates transcription from the serum response element". The Journal of Biological Chemistry. 276 (49): 46453–9. doi:10.1074/jbc.M105162200. PMID 11590143.
Koka S, Neudauer CL, Li X, Lewis RE, McCarthy JB, Westendorf JJ (May 2003). "The formin-homology-domain-containing protein FHOD1 enhances cell migration". Journal of Cell Science. 116 (Pt 9): 1745–55. doi:10.1242/jcs.00386. PMID 12665555.
Gevaert K, Goethals M, Martens L, Van Damme J, Staes A, Thomas GR, Vandekerckhove J (May 2003). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nature Biotechnology. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801. S2CID 23783563.
Tojo H, Kaieda I, Hattori H, Katayama N, Yoshimura K, Kakimoto S, et al. (July 2003). "The Formin family protein, formin homolog overexpressed in spleen, interacts with the insulin-responsive aminopeptidase and profilin IIa". Molecular Endocrinology. 17 (7): 1216–29. doi:10.1210/me.2003-0056. PMID 12677009.
Takeya R, Sumimoto H (November 2003). "Fhos, a mammalian formin, directly binds to F-actin via a region N-terminal to the FH1 domain and forms a homotypic complex via the FH2 domain to promote actin fiber formation". Journal of Cell Science. 116 (Pt 22): 4567–75. doi:10.1242/jcs.00769. PMID 14576350.
Lehner B, Semple JI, Brown SE, Counsell D, Campbell RD, Sanderson CM (January 2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region". Genomics. 83 (1): 153–67. doi:10.1016/S0888-7543(03)00235-0. PMID 14667819.
Katoh M, Katoh M (April 2004). "Identification and characterization of human FHOD3 gene in silico". International Journal of Molecular Medicine. 13 (4): 615–20. doi:10.3892/ijmm.13.4.615. PMID 15010865.
Wang Y, El-Zaru MR, Surks HK, Mendelsohn ME (June 2004). "Formin homology domain protein (FHOD1) is a cyclic GMP-dependent protein kinase I-binding protein and substrate in vascular smooth muscle cells". The Journal of Biological Chemistry. 279 (23): 24420–6. doi:10.1074/jbc.M313823200. PMID 15051728.
Westendorf JJ, Koka S (May 2004). "Identification of FHOD1-binding proteins and mechanisms of FHOD1-regulated actin dynamics". Journal of Cellular Biochemistry. 92 (1): 29–41. doi:10.1002/jcb.20031. PMID 15095401. S2CID 40202935.
Gill MB, Roecklein-Canfield J, Sage DR, Zambela-Soediono M, Longtine N, Uknis M, Fingeroth JD (June 2004). "EBV attachment stimulates FHOS/FHOD1 redistribution and co-aggregation with CD21: formin interactions with the cytoplasmic domain of human CD21". Journal of Cell Science. 117 (Pt 13): 2709–20. doi:10.1242/jcs.01113. PMID 15138285.
Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, et al. (June 2004). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nature Biotechnology. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
Lehner B, Sanderson CM (July 2004). "A protein interaction framework for human mRNA degradation". Genome Research. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, et al. (August 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Madrid R, Gasteier JE, Bouchet J, Schröder S, Geyer M, Benichou S, Fackler OT (January 2005). "Oligomerization of the diaphanous-related formin FHOD1 requires a coiled-coil motif critical for its cytoskeletal and transcriptional activities". FEBS Letters. 579 (2): 441–8. doi:10.1016/j.febslet.2004.12.009. PMID 15642356. S2CID 23740212.
Gasteier JE, Schroeder S, Muranyi W, Madrid R, Benichou S, Fackler OT (May 2005). "FHOD1 coordinates actin filament and microtubule alignment to mediate cell elongation". Experimental Cell Research. 306 (1): 192–202. doi:10.1016/j.yexcr.2005.02.006. PMID 15878344.
Schönichen A, Alexander M, Gasteier JE, Cuesta FE, Fackler OT, Geyer M (February 2006). "Biochemical characterization of the diaphanous autoregulatory interaction in the formin homology protein FHOD1". The Journal of Biological Chemistry. 281 (8): 5084–93. doi:10.1074/jbc.M509226200. PMID 16361249.

인간 염색체 16번 유전자에 대한 이 기사는 짧은 글이다.위키피디아를 확장함으로써 위키피디아를 도울 수 있습니다.

[refGRCh38Ensembl-1] GRCh38: 앙상블 릴리즈 89: ENSG00000135723 - 앙상블, 2017년 5월

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10352228-3] Westendorf JJ, Mernaugh R, Hiebert SW (May 1999). "Identification and characterization of a protein containing formin homology (FH1/FH2) domains". Gene. 232 (2): 173–82. doi:10.1016/S0378-1119(99)00127-4. PMID 10352228.

[pmid16112087-4] Boehm MB, Milius TJ, Zhou Y, Westendorf JJ, Koka S (October 2005). "The mammalian formin FHOD1 interacts with the ERK MAP kinase pathway". Biochemical and Biophysical Research Communications. 335 (4): 1090–4. doi:10.1016/j.bbrc.2005.07.191. PMID 16112087.

[entrez-5] "Entrez Gene: FHOD1 formin homology 2 domain containing 1".

[pmid11590143-6] Westendorf JJ (December 2001). "The formin/diaphanous-related protein, FHOS, interacts with Rac1 and activates transcription from the serum response element". The Journal of Biological Chemistry. 276 (49): 46453–9. doi:10.1074/jbc.M105162200. PMID 11590143.

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FHOD1

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레퍼런스

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