호모 사피엔스 종의 단백질 코드 유전자
ERBB 수용체 피드백 억제제 1은 ERRFI1 [5] [6] [7] [8] [9] 유전자 에 의해 인체 내에서 부호화되는 단백질 이다.
MIG6는 세포 성장과 함께 발현이 상향 조절되는 세포질 단백질 이다(Wick et al., 1995). 세포 스트레스 중에 유도되고 세포 신호를 매개하는 랫드 유전자-33의 단백질 생성물과 유의한 상동성을 공유한다(Makkinje 등, 2000; Fioneltino 등, 2000).[9]
상호 작용 ERRFI1은 Stratifin [10] CDC42 와 [5] 것 으로 나타났습니다.
레퍼런스 ^ a b c GRCh38: 앙상블 릴리즈 89: ENSG00000116285 - 앙상블 , 2017년 5월^ a b c GRCm38: 앙상블 릴리즈 89: ENSMUSG000028967 - 앙상블 , 2017년 5월^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ a b Makkinje A, Quinn DA, Chen A, Cadilla CL, Force T, Bonventre JV, Kyriakis JM (June 2000). "Gene 33/Mig-6, a transcriptionally inducible adapter protein that binds GTP-Cdc42 and activates SAPK/JNK. A potential marker transcript for chronic pathologic conditions, such as diabetic nephropathy. Possible role in the response to persistent stress" . The Journal of Biological Chemistry . 275 (23): 17838–47. doi :10.1074/jbc.M909735199 . PMC 3668664 PMID 10749885 . ^ Chrapkiewicz NB, Davis CM, Chu DT, Caldwell CM, Granner DK (August 1989). "Rat gene 33: analysis of its structure, messenger RNA and basal promoter activity" . Nucleic Acids Research . 17 (16): 6651–67. doi :10.1093/nar/17.16.6651 . PMC 318357 PMID 2780291 . ^ Fiorini M, Ballarò C, Sala G, Falcone G, Alemà S, Segatto O (September 2002). "Expression of RALT, a feedback inhibitor of ErbB receptors, is subjected to an integrated transcriptional and post-translational control" . Oncogene . 21 (42): 6530–9. doi :10.1038/sj.onc.1205823 PMID 12226756 . ^ Fiorentino L, Pertica C, Fiorini M, Talora C, Crescenzi M, Castellani L, Alemà S, Benedetti P, Segatto O (October 2000). "Inhibition of ErbB-2 mitogenic and transforming activity by RALT, a mitogen-induced signal transducer which binds to the ErbB-2 kinase domain" . Molecular and Cellular Biology . 20 (20): 7735–50. doi :10.1128/MCB.20.20.7735-7750.2000 . PMC 86354 PMID 11003669 . ^ a b "Entrez Gene: ERRFI1 ERBB receptor feedback inhibitor 1" .^ Benzinger A, Muster N, Koch HB, Yates JR, Hermeking H (June 2005). "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer" . Molecular & Cellular Proteomics . 4 (6): 785–95. doi :10.1074/mcp.M500021-MCP200 PMID 15778465 .
추가 정보 Zhang YW, Vande Woude GF (March 2007). "Mig-6, signal transduction, stress response and cancer" . Cell Cycle . 6 (5): 507–13. doi :10.4161/cc.6.5.3928 PMID 17351343 . Wick M, Bürger C, Funk M, Müller R (August 1995). "Identification of a novel mitogen-inducible gene (mig-6): regulation during G1 progression and differentiation". Experimental Cell Research . 219 (2): 527–35. doi :10.1006/excr.1995.1261 . PMID 7641805 . Hackel PO, Gishizky M, Ullrich A (December 2001). "Mig-6 is a negative regulator of the epidermal growth factor receptor signal". Biological Chemistry . 382 (12): 1649–62. doi :10.1515/BC.2001.200 . PMID 11843178 . S2CID 23424592 . Tsunoda T, Inokuchi J, Baba I, Okumura K, Naito S, Sasazuki T, Shirasawa S (October 2002). "A novel mechanism of nuclear factor kappaB activation through the binding between inhibitor of nuclear factor-kappaBalpha and the processed NH(2)-terminal region of Mig-6". Cancer Research . 62 (20): 5668–71. PMID 12384522 . Saarikoski ST, Rivera SP, Hankinson O (October 2002). "Mitogen-inducible gene 6 (MIG-6), adipophilin and tuftelin are inducible by hypoxia". FEBS Letters . 530 (1–3): 186–90. doi :10.1016/S0014-5793(02)03475-0 . PMID 12387890 . S2CID 37181106 . Anastasi S, Fiorentino L, Fiorini M, Fraioli R, Sala G, Castellani L, Alemà S, Alimandi M, Segatto O (July 2003). "Feedback inhibition by RALT controls signal output by the ErbB network" . Oncogene . 22 (27): 4221–34. doi :10.1038/sj.onc.1206516 PMID 12833145 . Xu D, Makkinje A, Kyriakis JM (January 2005). "Gene 33 is an endogenous inhibitor of epidermal growth factor (EGF) receptor signaling and mediates dexamethasone-induced suppression of EGF function" . The Journal of Biological Chemistry . 280 (4): 2924–33. doi :10.1074/jbc.M408907200 PMID 15556944 . Keeton AB, Messina JL (April 2005). "Modulation of Elk-dependent-transcription by Gene33". Journal of Cellular Biochemistry . 94 (6): 1190–8. doi :10.1002/jcb.20370 . PMID 15696545 . S2CID 3023317 . Benzinger A, Muster N, Koch HB, Yates JR, Hermeking H (June 2005). "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer" . Molecular & Cellular Proteomics . 4 (6): 785–95. doi :10.1074/mcp.M500021-MCP200 PMID 15778465 . Anastasi S, Sala G, Huiping C, Caprini E, Russo G, Iacovelli S, Lucini F, Ingvarsson S, Segatto O (June 2005). "Loss of RALT/MIG-6 expression in ERBB2-amplified breast carcinomas enhances ErbB-2 oncogenic potency and favors resistance to Herceptin" . Oncogene . 24 (28): 4540–8. doi :10.1038/sj.onc.1208658 PMID 15856022 . Ballarò C, Ceccarelli S, Tiveron C, Tatangelo L, Salvatore AM, Segatto O, Alemà S (August 2005). "Targeted expression of RALT in mouse skin inhibits epidermal growth factor receptor signalling and generates a Waved-like phenotype" . EMBO Reports . 6 (8): 755–61. doi :10.1038/sj.embor.7400458 . PMC 1369136 PMID 16007071 . Zhang YW, Staal B, Su Y, Swiatek P, Zhao P, Cao B, Resau J, Sigler R, Bronson R, Vande Woude GF (January 2007). "Evidence that MIG-6 is a tumor-suppressor gene" . Oncogene . 26 (2): 269–76. doi :10.1038/sj.onc.1209790 PMID 16819504 . 외부 링크 
